ID Q1QLM2_NITHX Unreviewed; 1738 AA.
AC Q1QLM2;
DT 16-MAY-2006, integrated into UniProtKB/TrEMBL.
DT 16-MAY-2006, sequence version 1.
DT 27-MAR-2024, entry version 90.
DE SubName: Full=Alpha-2-macroglobulin-like protein {ECO:0000313|EMBL:ABE62875.1};
GN OrderedLocusNames=Nham_2078 {ECO:0000313|EMBL:ABE62875.1};
OS Nitrobacter hamburgensis (strain DSM 10229 / NCIMB 13809 / X14).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Nitrobacteraceae; Nitrobacter.
OX NCBI_TaxID=323097 {ECO:0000313|EMBL:ABE62875.1, ECO:0000313|Proteomes:UP000001953};
RN [1] {ECO:0000313|EMBL:ABE62875.1, ECO:0000313|Proteomes:UP000001953}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 10229 / NCIMB 13809 / X14
RC {ECO:0000313|Proteomes:UP000001953};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA Hauser L., Kyrpides N., Ivanova N., Ward B., Arp D., Klotz M., Stein L.,
RA O'Mullan G., Starkenburg S., Sayavedra L., Poret-Peterson A.T.,
RA Gentry M.E., Bruce D., Richardson P.;
RT "Complete sequence of chromosome of Nitrobacter hamburgensis X14.";
RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
CC {ECO:0000256|ARBA:ARBA00010556}.
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DR EMBL; CP000319; ABE62875.1; -; Genomic_DNA.
DR RefSeq; WP_011510554.1; NC_007964.1.
DR STRING; 323097.Nham_2078; -.
DR KEGG; nha:Nham_2078; -.
DR eggNOG; COG2373; Bacteria.
DR HOGENOM; CLU_000965_1_0_5; -.
DR OrthoDB; 9767116at2; -.
DR Proteomes; UP000001953; Chromosome.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd02891; A2M_like; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.60.40.1930; -; 1.
DR InterPro; IPR026284; A2-macglob_dom_prot_bac.
DR InterPro; IPR049120; A2M_bMG2.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR021868; Alpha_2_Macroglob_MG3.
DR InterPro; IPR041203; Bact_A2M_MG5.
DR InterPro; IPR041462; Bact_A2M_MG6.
DR InterPro; IPR041246; Bact_MG10.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR40094; ALPHA-2-MACROGLOBULIN HOMOLOG; 1.
DR PANTHER; PTHR40094:SF1; UBIQUITIN DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF21142; A2M_bMG2; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF17973; bMG10; 1.
DR Pfam; PF11974; bMG3; 1.
DR Pfam; PF17972; bMG5; 1.
DR Pfam; PF17962; bMG6; 1.
DR Pfam; PF01835; MG2; 1.
DR PIRSF; PIRSF038980; A2M_bac; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001953};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..1738
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004196197"
FT DOMAIN 871..1015
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 1076..1165
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
SQ SEQUENCE 1738 AA; 185724 MW; 0E84BE0F1C4C2A49 CRC64;
MTGMVRTVVL CVALAIGFVS AQAADKVFKR DDLADAAIKL EAQIKSEAGT IAKSAPTLRT
DADAAFKRSD FRSGLHILGQ IATVAPDDSG NWLRLARTIF QIKPTTSQEQ TFLRERASTA
AYIAYQRARD PGAEADALAM LGRAFSERKL WRPALDTLGL SLDLREVADV REQYEKMRDD
HGFRLLDYTV DSDSASPRVC FQFSEDLAKR TDFSPFVALA GADRPALSSE DKQLCVDGLK
HGERYNINLR AGLPSTVKES LPKSAEFNVY VRDRKPFVRF TGRAYVLPRT GQRGIPLVSV
NTQAVSAQVF RIGDRNLINT VIDSDFQKTL SGYQLSDIGN ERGVKVWSGE VTTASTLNAD
VTTALPVDEA LGNLQPGVYV MTAAPKGPGS ANDEESGSLA TQWFIVSDLG LTAYSGNDGI
HVFVNSLATT DAVGKAEVRL IARNNEILAT RKTDESGHAL FEPGLAGGEG GLSPALLTVS
TDKADYAFLS LKSSAFDLTD RGVSGRAVPA GADAFVYAER GVYRSGETVY LTALLRDGQG
NAVTGGPLTL VVERPDGVEF RRAVLADQGA GGRSLTLPLN SAVPAGTWRV RAFTDPKGPS
VGETTFMVED YVPDRIEFDL MTMAKQIDAQ APVELKVDGH FLYGAPASGL QLEGDMLVAP
AASRPGYAGY QFGVADDETT SNERTPIENL PEADANGVAT FPVSLATPPS SSRPQEAQIF
VRMAEAGGRA VERKLVLPVA PAAAMIGVKP LFADKNVAEG DKAGFDVAFV APDGTSLARE
GLRYELLKLE SRYQWYRQNS YWEYEPVKST KRVADGDLTI AANKPARIEL SPQPGRYRLD
VKSSDPNGPL TSVQFDVGWY SDGSADTPDL LETSIDKQDY LSGDTMIVSV NARAAGKLTI
NVLGDRLLTT QTTEVKEGTS QVKIQVGKDW GTGAYVVATL RRPLDVAAQR MPGRAIGIKW
FGIDKTARTL SVNLSPPTLV RPSTTLKLPV KIGGLSPGED AKIVVAAVDV GILNLTNYKP
PAPDDYYLGQ RRMTSEIRDL YGQLIDGMQG TRGQLRTGGD SAGAELQGSP PTQKPLALYS
GIVTVAADGT AEISFDIPEF AGTARVMAVA WSATKLGRAT VDVTVRDPVV LTATLPRFLL
TGDQGTMSFD LDNVEGAPGD YTVNVKASGP VTVAGNPATT ITLAAKQRSS MALTLNAGGA
AGAAQFDVDI KGPNGLTLAR HYDLDVKPAT QILARRSVRT LAKGESLTLT SDMFSDLVAG
TGGVSMSVGL SSALDAATVL KALDRYPFGC SEQITSRAMP LLYVNDLAAG AHLAMDTGID
ERIKSSIDRL LARQGSNGSF GMWSSGGDDA WLDTYVTDFL TRAREKGFAV PETLFKSALD
RIRNSVVNAS EPEKDGGREL AYGLYVLARN GAAPIGDLRY LADTKLNNLA TPIAKAQLAA
ALALVGDRAR AERVYAAAAE SLAPKPVVEF GRTDYGSALR DAAALVSLAS EGNAPRATVT
QAVQRVEAAR GLTPFTSTQE NAWLVLAARA LAKESMSLDV DGTPVKTALY RSYKAAEMAD
KPIKIANTGD APVQAVISVA GAPMTPEPAV SNGFEIERNY FTLDGTPADP TQARQNDRLA
VVLRITEAKP EYGHIMVADY LPAGFEIDNP HLVSSGDAGT LDWIEEGQQP VNTEFRDDRF
TAAFDRAGND KAVFTVAYVV RAVSPGKYVL PQAYVEDMYN PSRYGRTGTG RVEVRPAK
//
