ID   Q1X7G7_MICTA            Unreviewed;       175 AA.
AC   Q1X7G7;
DT   02-MAY-2006, integrated into UniProtKB/TrEMBL.
DT   02-MAY-2006, sequence version 1.
DT   28-JUN-2023, entry version 50.
DE   RecName: Full=Brain-derived neurotrophic factor {ECO:0000256|RuleBase:RU364086};
DE            Short=BDNF {ECO:0000256|RuleBase:RU364086};
DE   Flags: Fragment;
GN   Name=BDNF {ECO:0000313|EMBL:AAY90049.1};
OS   Nesogale talazaci (Talazac's shrew tenrec) (Microgale talazaci).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Tenrecidae; Oryzorictinae; Nesogale.
OX   NCBI_TaxID=2583312 {ECO:0000313|EMBL:AAY90049.1};
RN   [1] {ECO:0000313|EMBL:AAY90049.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Mussell J.C., Allard M.W., Kilpatrick C.W.;
RT   "A reexamination of Lipotyphla and Afrotheria based on both molecular and
RT   morphological analyses.";
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: During development, promotes the survival and differentiation
CC       of selected neuronal populations of the peripheral and central nervous
CC       systems. Participates in axonal growth, pathfinding and in the
CC       modulation of dendritic growth and morphology. Major regulator of
CC       synaptic transmission and plasticity at adult synapses in many regions
CC       of the CNS. {ECO:0000256|RuleBase:RU364086}.
CC   -!- SUBUNIT: Monomers and homodimers. Binds to NTRK2/TRKB.
CC       {ECO:0000256|RuleBase:RU364086}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU364086}.
CC   -!- SIMILARITY: Belongs to the NGF-beta family.
CC       {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU364086}.
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DR   EMBL; AY986751; AAY90049.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q1X7G7; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR020430; Brain-der_neurotrophic_factor.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR020408; Nerve_growth_factor-like.
DR   InterPro; IPR002072; Nerve_growth_factor-rel.
DR   PANTHER; PTHR11589:SF3; BRAIN-DERIVED NEUROTROPHIC FACTOR; 1.
DR   PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR   Pfam; PF00243; NGF; 1.
DR   PIRSF; PIRSF001789; NGF; 1.
DR   PRINTS; PR01912; BDNFACTOR.
DR   PRINTS; PR00268; NGF.
DR   SMART; SM00140; NGF; 1.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR   PROSITE; PS50270; NGF_2; 1.
PE   3: Inferred from homology;
KW   Growth factor {ECO:0000256|RuleBase:RU364086}.
FT   DOMAIN          117..175
FT                   /note="Nerve growth factor-related"
FT                   /evidence="ECO:0000259|SMART:SM00140"
FT   REGION          1..36
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAY90049.1"
FT   NON_TER         175
FT                   /evidence="ECO:0000313|EMBL:AAY90049.1"
SQ   SEQUENCE   175 AA;  19418 MW;  C6148CA0C52E8CB0 CRC64;
     AAPMKEANIR GHGSMASYPG VRTHGTLESM SGPKAGSRSL TALADTFEHV IEELLDEDQK
     VRPNEENNKD ADMYTSRVML SSQVPLEPPL LFLLEEYKNY LDAANMSMRV RRHSDPARRG
     ELSVCDSISE WVTAADKKTA VDMSGGTVTV LEKVPVSKGQ LKQYFYETKC NPMGY
//