ID Q1ZZX0_MUSMM Unreviewed; 859 AA.
AC Q1ZZX0;
DT 18-APR-2006, integrated into UniProtKB/TrEMBL.
DT 18-APR-2006, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE SubName: Full=Toll-like receptor 5 {ECO:0000313|EMBL:ABD73995.1};
GN Name=Tlr5 {ECO:0000313|EMBL:ABD73995.1};
OS Mus musculus molossinus (Japanese house mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=57486 {ECO:0000313|EMBL:ABD73995.1};
RN [1] {ECO:0000313|EMBL:ABD73995.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=MOLF/Ei {ECO:0000313|EMBL:ABD73995.1};
RX PubMed=16688529; DOI=10.1007/s00335-005-0132-x;
RA Angers I., Sancho-Shimizu V., Descoteaux A., Gewirtz A.T., Malo D.;
RT "Tlr5 is not primarily associated with susceptibility to Salmonella
RT Typhimurium infection in MOLF/Ei mice.";
RL Mamm. Genome 17:385-397(2006).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634, ECO:0000256|PIRNR:PIRNR037595}.
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DR EMBL; DQ414410; ABD73995.1; -; Genomic_DNA.
DR AlphaFoldDB; Q1ZZX0; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-UniRule.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-UniRule.
DR GO; GO:0001819; P:positive regulation of cytokine production; IEA:UniProt.
DR GO; GO:0032680; P:regulation of tumor necrosis factor production; IEA:UniProt.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR PANTHER; PTHR24365:SF525; TOLL-LIKE RECEPTOR 5; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 4.
DR Pfam; PF01582; TIR; 1.
DR PIRSF; PIRSF037595; Toll-like_receptor; 5.
DR SMART; SM00369; LRR_TYP; 10.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 3.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859, ECO:0000256|PIRNR:PIRNR037595};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198,
KW ECO:0000256|PIRNR:PIRNR037595};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588,
KW ECO:0000256|PIRNR:PIRNR037595};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR037595};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 641..662
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 692..837
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 859 AA; 97866 MW; 14EFCBEDA6175558 CRC64;
MACQLDLLIG VIFMASPVLV ISPCSSDGRI AFFRGCNLTQ IPWILNTTTE RLLLSFNYIS
MVVATSFPLL ERLQLLELGT QYANLTIGPG AFRNLPNLRI LDLGQSQIEV LNRDAFQGLP
HLLELRLFSC GLSSAVLSDG YFRNLYSLAR LDLSGNQIHS LRLHSSFREL NSLSDVNFAF
NQIFTICEDE LEPLQGKTLS FFGLKLTKLF SRVSVGWETC RNPFRDVRLE TLDLSENGWT
VDITRNFSNI IQGSQISSLI LKHHIMGPGF GFQNIRDPDQ STFASLARSS VLQLDLSHGF
IFSLNPRLFG TLKDLKMLNL AFNKINKIGE NAFYGLDSLQ VLNLSYNLLG ELYNSNFYGL
PRVAYVDLQR NHIGIIQDQT FRLLKTLQTL DLRDNALKTI GFIPSIQMVL LGGNKLVHLP
HIHFTANFLE LSENRLENLS DLYFLLRVPQ LQFLILNQNR LSSCKAAHTT SENPSLEQLF
LAENMLQLAW ETGLCWDVFQ GLSRLQILYL SNNYLNFLPP GIFNDLVALR MLSLSANKLT
VLSPGSLPAN LEILDISRNQ LFSPDPALFS SLRVLDITHN EFVCNCELST FISWLNQTNV
TLFGSPADMY CMYPNSLLGA SLYNISTEDC DEEEAMRSLK FSLFILCTVT LTLFLVITLV
VIKFRGICFL CYKTIQKLVF KDKVWSLEPG AYRYDAYFCF SSKDFEWAQN ALLKHLDAHY
SSRNRLRLCF EERDFIPGEN HISNIQAAVW GSRKTVCLVS RHFLKDGWCL EAFRYAQSRS
LSDLKSILIV VVVGSLSQYQ LMRHETIRGF LQKQQYLRWP EDLQDVGWFL DKLSRCILKE
EKAKKRSSSI QLRTIATIS
//
