ID Q22183_CAEEL Unreviewed; 300 AA.
AC Q22183;
DT 01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT 01-NOV-1996, sequence version 1.
DT 27-MAR-2024, entry version 151.
DE SubName: Full=Nematode cuticle collagen N-terminal domain-containing protein {ECO:0000313|EMBL:CAA92476.1};
GN Name=col-122 {ECO:0000313|EMBL:CAA92476.1,
GN ECO:0000313|WormBase:T05A1.2};
GN ORFNames=CELE_T05A1.2 {ECO:0000313|EMBL:CAA92476.1}, T05A1.2
GN {ECO:0000313|WormBase:T05A1.2};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CAA92476.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CAA92476.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAA92476.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBUNIT: Collagen polypeptide chains are complexed within the cuticle
CC by disulfide bonds and other types of covalent cross-links.
CC {ECO:0000256|ARBA:ARBA00011518}.
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DR EMBL; BX284604; CAA92476.1; -; Genomic_DNA.
DR PIR; T24482; T24482.
DR RefSeq; NP_501700.1; NM_069299.5.
DR AlphaFoldDB; Q22183; -.
DR SMR; Q22183; -.
DR DIP; DIP-26231N; -.
DR IntAct; Q22183; 1.
DR STRING; 6239.T05A1.2.1; -.
DR EPD; Q22183; -.
DR PaxDb; 6239-T05A1-2; -.
DR PeptideAtlas; Q22183; -.
DR EnsemblMetazoa; T05A1.2.1; T05A1.2.1; WBGene00000696.
DR GeneID; 177789; -.
DR KEGG; cel:CELE_T05A1.2; -.
DR UCSC; T05A1.2; c. elegans.
DR AGR; WB:WBGene00000696; -.
DR WormBase; T05A1.2; CE03622; WBGene00000696; col-122.
DR eggNOG; KOG3544; Eukaryota.
DR GeneTree; ENSGT00970000195890; -.
DR HOGENOM; CLU_001074_4_2_1; -.
DR InParanoid; Q22183; -.
DR OMA; QSPCEPL; -.
DR OrthoDB; 5638100at2759; -.
DR PhylomeDB; Q22183; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00000696; Expressed in adult organism and 4 other cell types or tissues.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0042302; F:structural constituent of cuticle; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR InterPro; IPR002486; Col_cuticle_N.
DR PANTHER; PTHR24637:SF248; COL_CUTICLE_N DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24637; COLLAGEN; 1.
DR Pfam; PF01484; Col_cuticle_N; 1.
DR SMART; SM01088; Col_cuticle_N; 1.
PE 1: Evidence at protein level;
KW Collagen {ECO:0000313|EMBL:CAA92476.1};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|EPD:Q22183,
KW ECO:0007829|PeptideAtlas:Q22183};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..38
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 11..63
FT /note="Nematode cuticle collagen N-terminal"
FT /evidence="ECO:0000259|SMART:SM01088"
FT REGION 111..284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..223
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 300 AA; 29380 MW; 1D7DB56B3B957C88 CRC64;
MEDNKIKAYR LIGYAAVSLS AVGILSVCIT LPLVYSYVSN LRSQMHSELR HCRDTVNTVY
ATAVAMPALP GRGNRTARQA GYDVAVQDAP AQEHNSCDGC CLPGAAGSVG AAGRPGTPGR
PGAPGAPGHP GKPPQSPCEP LTPPPCPACP PGPPGAPGAP GKPGSEGPPG PPGHDGPNGG
PGQPGQPGPH GPNGHPGKPG SQGPPGPPGH SDEPKPGQPG QPGRAGPRGP RGVAGIKGKD
GAPGSPGQPG PRGGPGEPGQ DGAPGQPGLP GSDGTPGEKG ICPKYCAIDG GVFFEDGSRR
//
