ID Q22D89_TETTS Unreviewed; 825 AA.
AC Q22D89;
DT 18-APR-2006, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Cyclic nucleotide-binding domain protein {ECO:0000313|EMBL:EAR83236.2};
GN ORFNames=TTHERM_00998880 {ECO:0000313|EMBL:EAR83236.2};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR83236.2, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
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DR EMBL; GG662652; EAR83236.2; -; Genomic_DNA.
DR RefSeq; XP_001030899.2; XM_001030899.2.
DR AlphaFoldDB; Q22D89; -.
DR EnsemblProtists; EAR83236; EAR83236; TTHERM_00998880.
DR GeneID; 7839625; -.
DR KEGG; tet:TTHERM_00998880; -.
DR HOGENOM; CLU_339663_0_0_1; -.
DR InParanoid; Q22D89; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 2.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR Pfam; PF00027; cNMP_binding; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 2.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168}.
FT DOMAIN 274..363
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 553..576
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 111..138
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 825 AA; 96541 MW; 06D5CB69D5BB46C2 CRC64;
MIVFQNKIFD FPSNLLQKLK DNKHQEFVPP CQDLVYVLRQ FNYFKDQNVQ TENELIELAA
AKVFFKTYKQ GEYLTDQSQE DIIFILKGEV GLFEERNDRE IKQEHYWRQQ ISKIKRKIEE
TKDENEKVKL EEEYLKAEKV FNFYYKHEQV KLLSKDIQRH QINFNIDNEC LYKQTQIIKS
GVCVGPLTDH FERSKSSSNY QIVALNAVQA LVLNQQDQRE IFKKNAQIQT KLFCILSKYF
QSVAFERDIL QKVMRGVNEM CFTKNQSIYH ENFDTSQFLY VLVEGQVEIS AKRLKQQILI
DTINSNEIFG TEFLAANRSL RQFTARSQIN PTKIFAISYE TMKSLFNEEI MNEIKNYGEK
INNQYQETLS SHLKHIVNMC RQKGMKIPLN YQSNQITAST SANDQTVDNN TTTTLIHSKS
NNNSRSPFKR STLQRLSKKH SSIIEESIQN LKRQQTQLYC NSMSGNQSGS TNTSLLYNSG
FENKISALYN QISNKTGSNV NITCLKSRQN SIEMDLNEIV PPRVHFQQAS PSIDSIEDKQ
IIANACRESY YPKAQNSQQN YSSPQSGNQK QKAAQLNSKI TQNQLLKRYL SSRYSKQSQG
ENYISQNFED EVKRVEPLIR MSNTIAKDKF NSQAINLQNQ NTYQLQETPG KHVFEDMSPI
KKMRQYSVRE PKKNQQNENN QFFESSDAFT ANIIQQRRIL KQFKVKEEAE KYINSESTTK
SCQNSPVKRI KDEINIYNTP SHKNNQADKS LKNIYQSHYS LDKYKNKKNF KHRHSQSIAS
SLQYLNQNQQ NCKKQDQSPF QNENNRIMNN NYLSYSNFCK SLTNI
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