ID Q22MF6_TETTS Unreviewed; 2171 AA.
AC Q22MF6;
DT 18-APR-2006, integrated into UniProtKB/TrEMBL.
DT 18-APR-2006, sequence version 1.
DT 24-JAN-2024, entry version 78.
DE SubName: Full=NACHT domain protein {ECO:0000313|EMBL:EAR86429.1};
GN ORFNames=TTHERM_00035640 {ECO:0000313|EMBL:EAR86429.1};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR86429.1, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
CC -!- SIMILARITY: Belongs to the WD repeat LST8 family.
CC {ECO:0000256|ARBA:ARBA00009890}.
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DR EMBL; GG662720; EAR86429.1; -; Genomic_DNA.
DR RefSeq; XP_977064.1; XM_971971.3.
DR STRING; 312017.Q22MF6; -.
DR EnsemblProtists; EAR86429; EAR86429; TTHERM_00035640.
DR GeneID; 7847261; -.
DR KEGG; tet:TTHERM_00035640; -.
DR HOGENOM; CLU_000947_0_0_1; -.
DR InParanoid; Q22MF6; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0031931; C:TORC1 complex; IEA:InterPro.
DR GO; GO:0031932; C:TORC2 complex; IEA:InterPro.
DR GO; GO:0031929; P:TOR signaling; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 4.
DR InterPro; IPR037588; MLST8.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19842; G BETA-LIKE PROTEIN GBL; 1.
DR PANTHER; PTHR19842:SF2; WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G04300); 1.
DR Pfam; PF05729; NACHT; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 3.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000009168}.
FT DOMAIN 693..850
FT /note="NACHT"
FT /evidence="ECO:0000259|Pfam:PF05729"
SQ SEQUENCE 2171 AA; 257999 MW; 303C3AFD007A3D15 CRC64;
MNQKIEIQLA KGKSIEFKID DAGNITILFL NQKTSTKSEI NFTKKHHIAK IFRSGQFSKS
LLKKYLFENY YAFRIQQFQQ NIFLRGGGSG NTKINTQKIN EKLQTLSKNE LDYVEQNEND
NLIADYQEVL QFQQMELQQG TQQLQAEIYR MKQLKKEQKQ GELIQQEQKV KKLQQSNVRK
YQLKIEKILF CDIYIKLLTG DRLNFVGNKL YFIDLFEKYL DCLLRLSDYE IYSNKKDINK
QIEKLRKFER ICLDLSAKYP VQDILFYISL MIKIQEVNLE IYYEKYDGLT EAITLTSNLL
KLGYYGFKIN IADAALELVN IINFVYKKMD AFSSQGIFNA LLYIEIFKIQ NFTKTKNTQE
CENIYGQHLS KCFGQCYEGF DSHEILFYIS LIVNQEWNLK YIKDHNEMSL MYVLNKIDYL
LTLNFLQNHQ KFFLVQFQQN CQNEQFNLSN KLVIKFIEYI CDLFDTEFNE IKMFIIDSEV
YKLRIVYIIT SIMVKFFKIF SAKKIDDMME IVYLEDYSNI LLQNLWQHIC YIFITTRRLE
LQTIFEFAGN NFCCFMSDYL EKQKNIEKLQ QKFNVSFMEF EQKCVEKLIN LWDKFVSERK
VEGLELKDDL LHDVQDMYIN QRFKYLKGNN IFSKEQGDEE QLEISTPGNE TKITTVDKIK
NFFKTNKIQD QQNTTTIKLI RDNFLKQSDC VVLVILAEGG SGKSMLLKKI QIDLTHDSSQ
LYFPIFIKCN QLNQKYPTIE AVLSSDEYSI SNFDIIAIKK SSKRQKVILL DGYDEYTGDN
FNIYKDLNLS EWNNTKVILT SRKEKLDEHS IVQFVQVKEK NNNPEASFCI LDLLPFNDDD
IQIYCQNYIE KYRQSLMPTP DKDTTKHFFN KTKKSQKDQV KEQGTKELED HLANVQEALF
NILDQGNIYN IVKLPINLYL LTRIIHEIDQ DQINQIKYFD QVSLYQLFFK QYFKREAQNM
VEILMNTNTY QKTELISIQN LILEQYFDYF QSVAMKMFLQ KGQVTQFLVV NQKDIPVIIS
EDLKNSLKEE EDQQILIKRI QNYINNQIIN ILINQSSRIG SSNSQKYVNQ QLEFKHKSIY
EYFVARAMIN DFINYEKKGI RLSSLSEEDL QQFNINQRLI MINIQNQSEP EILIKLSHIL
NSIISENINK YTYKHQRQAI VFYLEYIFMT RFYSSLNIGS SNLLSALFQN NFAFDNLDLS
DCKFPYAYLF QSNKSTINFS NCHLKYALII DSLIDTKNAK IRKTIGSIVD SQYYKFNHME
VDDFEFSIDC SYFAFYNQQQ LQIWKYTKKF SLIQSFEGNY YQKKEKYKIQ SGFTQCNKYY
ITKKGDIWSI KEKKFILLNA QDDDYSTQDM QKKSNQNKIY IDNISILSFG NPYLLTINSK
GYKINIWDIR QKFQIYKVQE WPQQFESAVF SSQCNFVAIT QKDNSTYLLD GQNFIQIKEF
LRSKFVQFSF DEKYFILYQK NYKNDERYLS LFDIKCNLIK RFVITYLFRW YPKFSYDSKF
LQLKIFNRWG QKHQDIFLDI HNDFKCVGSY DYIKSIEFFK DNKIIIKKGD LFIVDNLKSN
IPLLVQNKAS NILKAIFSNQ LKYFVTLSNN NYQIYEITYG FKYIKEVEVR EQILEQALFS
QDDKYFATSL QTKEQTNICK VWDVGKYFQC KATIPCNQII DIKFNSNLQQ LIICEQAAIN
IYSIRSNFKL YYAIDLNALQ MDICLKNNYL VTLHEQEIKC WDLNDRFKNV IKKQISAKTR
CFKISQDFKY LFTVEQESFL SQDKYKINVF DFSNNLSMVE SIQENSMFLF TFDVRLNRLM
YEKDYYMCVW EMIDNKLQHI ITYPDSNYSN LNNKDLEDGL TIVQQYYYSQ DTKYLCEVNI
NKIKILNFNL DFHITNLPII ADRLTSLAFS KDCKYLITCT SEYKYSIWNL QKNFKLLIEI
KLDSRETEVQ FSQNNRYIAL YGKQKCIILD LNNNFEKIKE IQFDGDSIIT ALFSHQDHYL
ITGTQNGQLN IFDITKDFES IYQQQFYKQV KSIAVQSQNN LFAVATSSGL VGVYSFETKF
LMRVLISEDN LGQIAISPNG QYLIAVCAKS IYLWDLFQNY DKIELEFQFK SKIATFTDKY
LILVDADKGL VILDPYQNFK QVSECKVHEK EITCMDITKD YKFLALGFKA SMCKVWDFQK
YIERDNILYQ I
//
