ID Q22MR2_TETTS Unreviewed; 1440 AA.
AC Q22MR2;
DT 18-APR-2006, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Cation channel family protein {ECO:0000313|EMBL:EAR86527.2};
GN ORFNames=TTHERM_00031600 {ECO:0000313|EMBL:EAR86527.2};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR86527.2, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
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DR EMBL; GG662720; EAR86527.2; -; Genomic_DNA.
DR RefSeq; XP_976958.2; XM_971865.2.
DR EnsemblProtists; EAR86527; EAR86527; TTHERM_00031600.
DR GeneID; 7828688; -.
DR KEGG; tet:TTHERM_00031600; -.
DR eggNOG; KOG0500; Eukaryota.
DR HOGENOM; CLU_255419_0_0_1; -.
DR InParanoid; Q22MR2; -.
DR OrthoDB; 52684at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR013099; K_chnl_dom.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR001878; Znf_CCHC.
DR PANTHER; PTHR45689; I[[H]] CHANNEL, ISOFORM E; 1.
DR PANTHER; PTHR45689:SF5; I[[H]] CHANNEL, ISOFORM E; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF07885; Ion_trans_2; 1.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
DR PROSITE; PS50158; ZF_CCHC; 1.
PE 4: Predicted;
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00047};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00047};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00047}.
FT TRANSMEM 385..406
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 412..435
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 456..475
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 510..534
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 593..616
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 698..804
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 831..845
FT /note="CCHC-type"
FT /evidence="ECO:0000259|PROSITE:PS50158"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 109..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 955..985
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1155..1175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1307..1335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 128..144
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1440 AA; 169866 MW; 2E33BAB3C462A7B1 CRC64;
MSSQKVQKTK NRYSKSQQFE PLAGLNRELR TEDSDRKITD TNLLLKQNMT TQSDYENAIK
TQEVIIDTEV SQHALMHYPK NGNNNNKVED NVEDNEEDND VFDILYGQIQ NDKSNRQIQE
DSSKVKSDQQ NTKPQQYETK KSGSFLNQDY YELQNMKEQQ ASEQIEQYSN GQNNQDNIIR
NAQSINIRIP LQETLDKDLK IDSEQQKNIQ ELNNKKTDSM KNSRFQNQSV FQDKLRYIQN
LKNRQNKEIN QNKRDSLALF KNATPSNQED SQQEINKKLF VQNRKTLQGT VIINEGDNTN
NKLVTQKANQ NWNMVKKLSI MMRFKQKLNK IIQQRLQNIK DFHHRMIGDC TDAPILKMEE
KKENIKSLYY KIFLETYNPE SLLIIYYKIF ITLYTLFNVI YLPLIFGFDL DLGTAFIAIH
SCTIIIFLFE IYASFRIQYY HLGELVTDRN QIYSKYLNNK FITDLITIIA LVIGYDKKPA
LLFILVKIRN ILSYLWDIDN HYYLAERYNA LWILIKLFGF IAILCHYFAC IFHYTGMVQE
HKYPDVTTWT REFNLIGQPW SLRYNYSIYF SFITCITIGY GDITPKNTNE RNIVILISLI
STGCFSYSVN TMATVFQDFL NKSKKSKEMR YDAINYMRER NIHKNLQLRV LKYIEYIYQM
EAQSPDKGLF AINQISGHLK AQLFQDYYGK IIIQDKHFSL NYSKETIDKL SLKMKERIYG
PGEIIFDQGE QDTRIFFLMK GEIEYYYPNR GNKQSEYLSI FQTQQNQFFG YKGFISGIPR
EMTCRSINIT QVFYCTREDL VSILKENPLE YEKFCKLRDE YLLQYSSLGE KCFSCNEYGH
TISDCYKIRY VKNKELLILK KNYSANQVRQ FVQRSNKKYA TFLNMSITSF EAIKCKLKNV
MQLQRQHLSE EVIDKIIIQE QSNHKRFCLK YPSIKLTENC NEILLGKMDE PFEYSTSDSD
SNLSQISEDE SLSEQSSSGL YDLDSTQRDQ TLNNIQKSEN KRSFAKSFKL NQEQNLEDIQ
YDDNENKDEF QEQTNKVQKI EFTLEKQNSN QGLLKDSSNY QITENNQSEQ IAQNLIGNEY
SKNTNIYDSG VKNKILLNTP QSNNPQDREY EITKQLIGSP SLGSQEMLNR YANESKAKSI
QWNKNANKKS ILIKSNSQNQ DQDKPTKMNS QSKIQLNRKS INNFQKANKY IQKLREKFDI
APSQTDENKY LSSTAQRFAN VAQELTMTNT YEDKNVSILA NKKSAQYPQY EQYNSKQMNN
SNKYETNENI INFYQGQINR LGQFLNYFQN QQKSSNKIQV NSTNNLANDF QNQLPPPPPR
QHSINKTEKQ ESSLSYPQKR MAVLDLNEFL LKANKQDIFK NFLQDEEVEN NQELFYYDFD
FLKEFTYYFP QNNHTAVCLN YKRIMKKLQQ SQRKNIKQIN VNQPIASQRQ NFSKFKKDSY
//
