ID Q22XM0_TETTS Unreviewed; 681 AA.
AC Q22XM0;
DT 18-APR-2006, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Nucleotidyltransferase domain protein {ECO:0000313|EMBL:EAR89990.2};
GN ORFNames=TTHERM_01050360 {ECO:0000313|EMBL:EAR89990.2};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR89990.2, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
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DR EMBL; GG662806; EAR89990.2; -; Genomic_DNA.
DR RefSeq; XP_001010235.2; XM_001010235.2.
DR AlphaFoldDB; Q22XM0; -.
DR STRING; 312017.Q22XM0; -.
DR EnsemblProtists; EAR89990; EAR89990; TTHERM_01050360.
DR GeneID; 7826516; -.
DR KEGG; tet:TTHERM_01050360; -.
DR eggNOG; KOG2277; Eukaryota.
DR HOGENOM; CLU_413085_0_0_1; -.
DR InParanoid; Q22XM0; -.
DR OrthoDB; 1080369at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR CDD; cd05402; NT_PAP_TUTase; 1.
DR Gene3D; 1.10.1410.10; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR041633; Polbeta.
DR PANTHER; PTHR12271; POLY A POLYMERASE CID PAP -RELATED; 1.
DR PANTHER; PTHR12271:SF40; POLY(A) RNA POLYMERASE GLD2; 1.
DR Pfam; PF18765; Polbeta; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81631; PAP/OAS1 substrate-binding domain; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000009168}.
FT DOMAIN 378..433
FT /note="Polymerase beta nucleotidyltransferase"
FT /evidence="ECO:0000259|Pfam:PF18765"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EAR89990.2"
SQ SEQUENCE 681 AA; 80766 MW; 7959E1A8ABFF89EB CRC64;
KKNQLELKFY QLRKQIVMSL YNKYKQILTE LITTSKQEDL SNPSINFDQK LAYTIKKYMD
IPFKYSKGFE DYIKQQVEII CKNEQNIEFF INWRNLIEQL KEKTKILTKQ SITLLDSLIE
TANSRFEALK TENQLKQEED FTNQIKMNQS NIQMSDKSMN GLLHTQSSNQ IKSSTINQQD
LEQKLQAQSD NNQNLNCLHP QQQSQQHQIL NNNNIQDFNN KYEQLMTQQG DYLTNNNINQ
KQNSNLNNQQ QHNQVKCVNN NWSSNDMEKY LIQQEGKQAL LKSEYKSNQV ENQNLFDSSI
GWQTFDQQSK KFIIENEILI YQDESIYLNS IKNVDKIDQK LYEIYSNQIL EQDKKKKMME
QLKYVLNNIQ QNAEIQISKD IILKAYLFGS FLQGTCLKKE SDIDLIIIFE NNQLSYRDTL
LFIQETIKNK LNDQYIITQE VSFAFNVPII SIQHVKTGYK IDITYENRLA ILNSQLFNVY
LNIDFKIKVL SVLFKIWAVK QNIKKTDFLT SYALLNMVIY FLISQGYLVS LQHSQYFGFA
HQKENIINYS KGQKETQQIY TSFEKNIGQI KSKLVNQLQK LNEKPLHKLI TELFSFYRVI
LNHNDQCKQH EKIIITTRLS TNIMGVLKYD QNKQYISIQD PFNDQYNPGQ RWNFDVNYFY
QKLSQVPLQF QDIDQLSELF D
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