ID Q232Y2_TETTS Unreviewed; 402 AA.
AC Q232Y2;
DT 18-APR-2006, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 2.
DT 27-MAR-2024, entry version 90.
DE SubName: Full=Histone deacetylase family protein {ECO:0000313|EMBL:EAR91698.2};
GN ORFNames=TTHERM_00395710 {ECO:0000313|EMBL:EAR91698.2};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR91698.2, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
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DR EMBL; GG662770; EAR91698.2; -; Genomic_DNA.
DR RefSeq; XP_001011943.2; XM_001011943.2.
DR AlphaFoldDB; Q232Y2; -.
DR STRING; 312017.Q232Y2; -.
DR EnsemblProtists; EAR91698; EAR91698; TTHERM_00395710.
DR GeneID; 7822698; -.
DR KEGG; tet:TTHERM_00395710; -.
DR HOGENOM; CLU_007727_1_1_1; -.
DR InParanoid; Q232Y2; -.
DR OrthoDB; 239005at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004407; F:histone deacetylase activity; IEA:InterPro.
DR CDD; cd09993; HDAC_classIV; 1.
DR Gene3D; 3.40.800.20; Histone deacetylase domain; 1.
DR InterPro; IPR044150; HDAC_classIV.
DR InterPro; IPR000286; His_deacetylse.
DR InterPro; IPR023801; His_deacetylse_dom.
DR InterPro; IPR037138; His_deacetylse_dom_sf.
DR InterPro; IPR023696; Ureohydrolase_dom_sf.
DR PANTHER; PTHR10625:SF33; HISTONE DEACETYLASE 11; 1.
DR PANTHER; PTHR10625; HISTONE DEACETYLASE HDAC1-RELATED; 1.
DR Pfam; PF00850; Hist_deacetyl; 1.
DR PRINTS; PR01270; HDASUPER.
DR SUPFAM; SSF52768; Arginase/deacetylase; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..29
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 136..155
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 100..382
FT /note="Histone deacetylase"
FT /evidence="ECO:0000259|Pfam:PF00850"
SQ SEQUENCE 402 AA; 46316 MW; 902D49DED162F261 CRC64;
MYTLICAVQD LALFGIFITG LVLLEWQIIV FPILIYILIP FLNELVYNCF AKLLFTIEKE
KKRMEQRYSQ SELENKYIEN LPILYHPSYN ITACGIEKLH PFDSVKYGRV FNILKEKGFL
QEQGFYKPKE KVGRGLMLHL GMSPLYLLYL NYAAYVSKCI EIPLFFLPAS FLRWKVLDPM
MFSTQGSIDA AVLSLKRGWS INLSGGYHHA CRQSGGGFCI YPDICFAIEY LRKCFGIKRC
MIVDLDAHQG NGHERDFIDD KENTFILDFY NHSIYPADTF AAKGISLSKN VDFDTSDSEY
ISMLRKTLQK ILDQFKPEFL LYNAGTDCLE GDRLGQMNLS QNCIIQRDQV VFEECLNRDI
PLTMVLSGGY QQINAPVIAD SILNLDQNLK IKNYNRKKLQ NP
//
