ID Q234I5_TETTS Unreviewed; 652 AA.
AC Q234I5;
DT 18-APR-2006, integrated into UniProtKB/TrEMBL.
DT 18-APR-2006, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE RecName: Full=Heat shock 70 kDa protein {ECO:0000256|ARBA:ARBA00018181};
GN ORFNames=TTHERM_00105110 {ECO:0000313|EMBL:EAR92018.1};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR92018.1, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
CC -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC {ECO:0000256|ARBA:ARBA00007381, ECO:0000256|RuleBase:RU003322}.
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DR EMBL; GG662767; EAR92018.1; -; Genomic_DNA.
DR RefSeq; XP_001012263.1; XM_001012263.3.
DR AlphaFoldDB; Q234I5; -.
DR STRING; 312017.Q234I5; -.
DR EnsemblProtists; EAR92018; EAR92018; TTHERM_00105110.
DR GeneID; 7828131; -.
DR KEGG; tet:TTHERM_00105110; -.
DR eggNOG; KOG0101; Eukaryota.
DR HOGENOM; CLU_005965_3_2_1; -.
DR InParanoid; Q234I5; -.
DR OMA; KANPIMM; -.
DR OrthoDB; 3028330at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR CDD; cd10233; HSPA1-2_6-8-like_NBD; 1.
DR Gene3D; 1.20.1270.10; -; 1.
DR Gene3D; 3.30.30.30; -; 1.
DR Gene3D; 3.30.420.40; -; 2.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR018181; Heat_shock_70_CS.
DR InterPro; IPR029048; HSP70_C_sf.
DR InterPro; IPR029047; HSP70_peptide-bd_sf.
DR InterPro; IPR013126; Hsp_70_fam.
DR PANTHER; PTHR19375:SF395; HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED; 1.
DR PANTHER; PTHR19375; HEAT SHOCK PROTEIN 70KDA; 1.
DR Pfam; PF00012; HSP70; 1.
DR PRINTS; PR00301; HEATSHOCK70.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR SUPFAM; SSF100934; Heat shock protein 70kD (HSP70), C-terminal subdomain; 1.
DR SUPFAM; SSF100920; Heat shock protein 70kD (HSP70), peptide-binding domain; 1.
DR PROSITE; PS00297; HSP70_1; 1.
DR PROSITE; PS00329; HSP70_2; 1.
DR PROSITE; PS01036; HSP70_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU003322};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003322};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW Stress response {ECO:0000313|EMBL:EAR92018.1}.
FT REGION 620..652
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 576..608
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 652 AA; 71441 MW; 918E6541CD4A42E6 CRC64;
MADKKAEGGI GIGIDLGTTY SCVGVFINDR VEIIANDQGN RTTPSYVAFT ETERLIGDAA
KNQVARNPTN TVFDAKRLIG RKFNETVVQK DIKLWPFKVE AGPDDKPKIV VKHKGEVKKF
HAEEISSMVL VKMREIAEAF LTKQIKNAVI TVPAYFNDSQ RQATKDAGAI AGLNVLRIIN
EPTAAAIAYG LDKKGQGEKN VLIFDLGGGT FDVSLLTLDD GIFEVKATAG DTHLGGEDFD
NKLVEFCAAD FLKKKNIDIR ENPRAMRRLR TQCERAKRIL SSSAQATIEV DALADSEDFM
MVISRPKFEE LCLSMFKECI PPVEKVLKDS GMAKNQVHEV VLVGGSTRIP KVIQLITEFF
NGKEPNRSIN PDEAVAYGAA IQAAILTGSG SEHIQDVLLL DVTPLSMGIE TAGQVMTVLI
PRNTTIPTKK SQVFTTYADN QPGVLIQVFE GERPMTKDNH LLGKFNLDGI APAPRGVPQI
EVSFDIDENG ILNVTATDKG TSKSNKITIT NQKGRLSQDE IDRLIKEAEK FKGEDEALKK
KVEAKNGLEN YTYSIRNSLK DEKLKDKFSA EEREKVQKLV DETSKWLEEN HNAEAEEYSH
KQKALEEVFN PIMMRVYQST GGVPPGADMG GAGFPGSGSA PTGGASNVDE VD
//
