ID   Q23AZ8_TETTS            Unreviewed;       912 AA.
AC   Q23AZ8;
DT   18-APR-2006, integrated into UniProtKB/TrEMBL.
DT   18-APR-2006, sequence version 1.
DT   27-MAR-2024, entry version 57.
DE   SubName: Full=von willebrand factor type A domain protein {ECO:0000313|EMBL:EAR93686.1};
GN   ORFNames=TTHERM_00653790 {ECO:0000313|EMBL:EAR93686.1};
OS   Tetrahymena thermophila (strain SB210).
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR93686.1, ECO:0000313|Proteomes:UP000009168};
RN   [1] {ECO:0000313|Proteomes:UP000009168}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX   PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA   Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA   Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA   Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA   Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA   Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA   Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA   Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA   Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA   Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA   Hamilton E.P., Orias E.;
RT   "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT   model eukaryote.";
RL   PLoS Biol. 4:1620-1642(2006).
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DR   EMBL; GG662720; EAR93686.1; -; Genomic_DNA.
DR   RefSeq; XP_001013931.1; XM_001013931.3.
DR   AlphaFoldDB; Q23AZ8; -.
DR   STRING; 312017.Q23AZ8; -.
DR   EnsemblProtists; EAR93686; EAR93686; TTHERM_00653790.
DR   GeneID; 7842211; -.
DR   KEGG; tet:TTHERM_00653790; -.
DR   HOGENOM; CLU_319001_0_0_1; -.
DR   InParanoid; Q23AZ8; -.
DR   Proteomes; UP000009168; Unassembled WGS sequence.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR013694; VIT.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR45737; VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A; 1.
DR   PANTHER; PTHR45737:SF6; VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN DDB_G0286969-RELATED; 1.
DR   Pfam; PF13768; VWA_3; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS51468; VIT; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000009168}.
FT   DOMAIN          7..143
FT                   /note="VIT"
FT                   /evidence="ECO:0000259|PROSITE:PS51468"
FT   DOMAIN          307..484
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   REGION          704..769
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        715..769
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   912 AA;  102400 MW;  49B193D23154876A CRC64;
     MFGLIDASQQ TSQVNNNSSL PYLQNEHFEV LIGHGIARVK VVQHYLNFNQ NEQAHLEFYF
     PQSKNLILES FLAELEQSKR NLESSLSSNL NDSSECKREE QKIAEKIGKN KFPNGILVDG
     WVRFKIAVVK PQESIIISLV YSHKLAVSRE GYHTFQLPQQ AITASYPISA KIHFEDRQKE
     DSITYHSLNH EVAVFQQPIL LDNGAGQGLQ HLSLRANYSH SSDKPFIINF FNKDYSNVQK
     IYLNSSLLPS DKQSQDSAYA LVTIVPSLLS GVSCLSQLEE KLKHPHFNNE KLECIMKHLQ
     VSKSQSEIII LLDRSSSMGS QKFSQAIEGI SLLLRSLPTN SYFNIISQGS GNRLESVFES
     SVIYSQENLS HSINRINDFQ NNLGTSFNIL NSLKHIEGQK SIANYARQIV LISDPSELEN
     KLEEIYQYLE TSKLGSPIHT VNVESRQSSD STIFEVISSL TGGNSISNKY NSNESITDSI
     LKMLPTLFQP TLCNFELDSK ASENFISQVI PVEQNLKSIQ FNEQISLVLA LKNTSKEQSL
     PLSFKFFSSA LNKVEEHQID LLGSQVEGSS HISNDLKKSL LKFCAHQHII SLKNKNTDEI
     KSLSLQYSVL AEDHTFWITK CYQLSENGQD KNLIAGQEQL PSIREKSCDD SHFVQQTRKV
     SATSNLMQLY DNQSGQENQT PSDGQERSKS QDLNNLIDAI FTGEPQKQPE QEQAHSKKSG
     SISSHGQNTD LLDIGDDVSQ TTNPSQGHMS TVSNTAQNGD PNSDLNDDIL DLIQNNNNIQ
     QNNNQIQCNN GNAIDLLDDF LIGDSPSQSQ SKSVSLLDIL QNINYEGIFN SNKFILNSLL
     NENLDKFIGD KPENLTLDQW STLLVLTSLE KNFTQEALKW GVLAKKGKEQ LQKVLSGNLF
     DEICNKSKIY LK
//