ID   Q23F76_TETTS            Unreviewed;       665 AA.
AC   Q23F76;
DT   18-APR-2006, integrated into UniProtKB/TrEMBL.
DT   18-APR-2006, sequence version 1.
DT   27-MAR-2024, entry version 71.
DE   SubName: Full=AMP-binding enzyme family protein {ECO:0000313|EMBL:EAR95277.1};
GN   ORFNames=TTHERM_00382380 {ECO:0000313|EMBL:EAR95277.1};
OS   Tetrahymena thermophila (strain SB210).
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR95277.1, ECO:0000313|Proteomes:UP000009168};
RN   [1] {ECO:0000313|Proteomes:UP000009168}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX   PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA   Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA   Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA   Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA   Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA   Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA   Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA   Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA   Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA   Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA   Hamilton E.P., Orias E.;
RT   "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT   model eukaryote.";
RL   PLoS Biol. 4:1620-1642(2006).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; GG662706; EAR95277.1; -; Genomic_DNA.
DR   RefSeq; XP_001015522.1; XM_001015522.3.
DR   AlphaFoldDB; Q23F76; -.
DR   STRING; 312017.Q23F76; -.
DR   EnsemblProtists; EAR95277; EAR95277; TTHERM_00382380.
DR   GeneID; 7840897; -.
DR   KEGG; tet:TTHERM_00382380; -.
DR   eggNOG; KOG1256; Eukaryota.
DR   HOGENOM; CLU_000022_45_4_1; -.
DR   InParanoid; Q23F76; -.
DR   OMA; MAILMYT; -.
DR   OrthoDB; 22305at2759; -.
DR   Proteomes; UP000009168; Unassembled WGS sequence.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   PANTHER; PTHR43272; LONG-CHAIN-FATTY-ACID--COA LIGASE; 1.
DR   PANTHER; PTHR43272:SF3; LONG-CHAIN-FATTY-ACID--COA LIGASE 5; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000009168}.
FT   DOMAIN          72..485
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
SQ   SEQUENCE   665 AA;  74686 MW;  934EB063EF88EE4E CRC64;
     MGNQAPQLVY SVECSEKKEG ETSIRRSPVS ALGLKKQPEK DILTMQDAWI KVVKTCGDQQ
     FLFTRNKQTN IYEGKTYNEV NALARALGSA IVHEKLYYES NEDSRFPGLK MVGIFAKNCE
     EWTIFDVSNM LYGHVAIPLY DTLGPQNITY CLKHSGIITC IASGASVSQF VKTTDIGSLK
     NIIVIDDVKP EDKLAMEQRG VKFYSWDAII NIGKLNPKDI VQVQETDCLT FSYTSGTTGD
     PKAAMMSHQN FNSVLAALKY HPNVKFYPDD VHLSYLPMPH VFERVFVYAV LSQGAKIYFY
     SGDVQKLKDD LAVVKPTFFI SVPRLYNRFY DLINQQFEKQ TGVQKFLLNM ALSTKFEGIK
     TGKCTHALYD KLIFSKTKQL FGGRCRFLVT SSAPISKDVI DFMKVISCVP MIEGYGQTES
     TGATFTTFFE DPESGHCGGP TAAAEYKLVD VPDMNYFSTD KNEKGEPQPR GEICFRGTGN
     FMGYFKDLAK TNEAIDKDGW LHTGDVGMIL PHTQALKIID RKKNIFKLQQ GEYVAPEKVE
     NSYLKVRGIQ EIFVYGDSLQ SYCIAIAVLE KAFIEDLGKQ KNISGTYEEL CQNPEIVSAV
     LASLEKQGRA DKLAGFELAK KLYIHPESMA NLNCMTTTMK IQRHNAKNVF KQQIDKMYST
     PLANA
//