ID Q23GA0_TETTS Unreviewed; 2183 AA.
AC Q23GA0;
DT 18-APR-2006, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 3.
DT 27-MAR-2024, entry version 94.
DE SubName: Full=Ibr domain protein {ECO:0000313|EMBL:EAR95360.3};
GN ORFNames=TTHERM_00075650 {ECO:0000313|EMBL:EAR95360.3};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR95360.3, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR EMBL; GG662704; EAR95360.3; -; Genomic_DNA.
DR RefSeq; XP_001015605.3; XM_001015605.3.
DR STRING; 312017.Q23GA0; -.
DR EnsemblProtists; EAR95360; EAR95360; TTHERM_00075650.
DR GeneID; 7842822; -.
DR KEGG; tet:TTHERM_00075650; -.
DR eggNOG; KOG1815; Eukaryota.
DR HOGENOM; CLU_232644_0_0_1; -.
DR InParanoid; Q23GA0; -.
DR OrthoDB; 1376344at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd20335; BRcat_RBR; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR002867; IBR_dom.
DR InterPro; IPR044066; TRIAD_supradom.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR22770:SF13; RING-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR22770; UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED; 1.
DR Pfam; PF01485; IBR; 1.
DR SMART; SM00647; IBR; 1.
DR SUPFAM; SSF57850; RING/U-box; 2.
DR PROSITE; PS51873; TRIAD; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT TRANSMEM 2086..2119
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2131..2155
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1854..2066
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS51873"
FT DOMAIN 1858..1905
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 141..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 438..462
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 540..575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 730..760
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 778..801
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1305..1337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 152..184
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 544..566
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 730..756
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 780..796
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1318..1337
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2183 AA; 252214 MW; CB93D7E1169EEFB1 CRC64;
MQQAQFSQQQ QIQQQQQQQQ PQQQQQQLQT NLQPTMQNVQ NSQYNQSPYI GVELPHLYLK
KAKPFSQIST TATPQTNSSF AHQFPSPALL ANANSINKNS SSNSACIQIQ KLESTPTPQL
FKQISTTPLL LSQTSQSASV PLVNLTPPKS HTKEQSKFKG NVKESDVKMK KKGSKSKKQE
ESAGTSKRVP IMQQVGRGKS QPITANYQIE QTAKQNFNIH RSPLTPNFLS NQLIEADLFS
KKGNKSVKKG SPSNKNQNKN YQTMQAPAFS NNMQGGMIEL ALKNKSTQKK QSKNNFLDDK
LQDDQKTLES KQSYLLNYEH QESVAQFLPS FNGMKTPFSQ QFQSQKHIQQ HQSVQQQQQQ
NMPPQIYQQI QTKYAEPQDY NLYQKTSYNN FQINPAHVSL QQYQLKQPNQ FSQYQSIIPN
YFESQQQFKE VNLLTSSVSS NSSGQMANQS ENQQSTAQNS EKKLNAKNNS QIFNTINLQA
NKNLITSQNQ SKKSNKKNSL AKSQTFYKNT NQQQQGIYNQ NRLQNPQENY LYYLEQNNDK
HEVKEEEDEE EEEEEEEDDD EEEEVIDQIK QQQQQFMHEN NNNHQINKQN KWTHLFIGQT
NKQSANKQIQ QNIQHNQMQQ TLQQSQIQQN LQHGQMQQNL QYNQALQNLQ QSQIQSNLQP
IQDQNLYSQY NSDDFQEEDE HENQLQNIRF YSEKNFPLYY DQHLYQLYQQ GQNITINPNQ
NGNQVYEITE GEDDEDDDEE EEEEEEEDEE EETEEQENKQ IIFMGNRQND IYFRNNEQEE
QEVSEEDQDE DDVDYDDESQ SRVKNKINKN RLFEDDVENQ FQSSDFDAQK NDMKMYNQAE
YQQTRINMGS KNNLSVDKIN SLTQVNTSNY DQMKSLISPK SRVSSYQQFS TLKFQKSNSN
NNQMRSNTSL GEDGNNQIEL EMDDEEDSHL TSFANNKNPS NIPNLVNKQT KFKKKSNTIS
SRGSYVSEQE QMQEGNKIMQ KNPSQFLQTS QGIQQNQNFN LPVTIRNNSK KKSKTANFQP
QHQILYQNFN KDAFQAGVEI NNEYFQGNQV GSIIFAQQQQ QVQFNNCNQY KFNIQNVNIQ
HPGNVSQIID NQKILFKNNN QNENMKVNQS DINLQHQIKG FDQIYEVNDV NNSIIEKQVP
EPPPPAGSQY SKHEIQQVNN IINYTHKNSF SSSASKVNTN QNSLKNLEQN NNNNNSKRGS
FYTLQSASNN NNQIIDAKSK VKLMHLSSAE VTPQGSQLGN TPQKGIINLN NFTISPRLYG
NDQINNTQIT QSILFIPQQF NQLKRDQFFL EDQQDNLKSY LANKNKQQLK KKQSDDTTSI
TNHLSNSPNN NNNNNNTQNI QVQQKLQSQN KKSKKHKQSK SCVKICMSTV LLDNNTNNDD
NKNTKQRVYS QQPYLEDPQI KKKWVLSRAS KMQIDPRLAN QLIEEINLYQ HSKEVILEKL
IQSILSYQTL KGKLKKKDNN NEVSVVQAAK NRTTQIFRSV SQLFTSTSNS NPSQQEIQQK
MMQRMVNNGT QAAVATTLNN RTTTNDNQVT CEQEDCTRYE KDYIQENNSY EDEKKAYAKN
TQVHNYKDII QTTMATTTAA GQLSVYNNNS HIHSINNLPN SFISKKANYL KGTSNDKNNT
INTLSSINNL PSASNQALKA ISNVSYNNAV NHSTCPNSVN IISDNNIPGA IINGSICSSS
NIQLVQQNSQ QVSLFSPNQK DKTIRIKKSN KNINQFDMSN NQQQSIILEQ DGQKHKKVNA
PISYQQIGSD KQAQHKKKEI SKHHNFNTKM MDLSSISVSI DPIHAIVTPK LPNNSKKSLI
SSQINANKES KSLEYKQNPQ TISAYVQAVL PSQQSSKLAE FQINQREQSF SFNNQNICPI
CQHETQLFAL NYKCEHKFCM YCIRQYIENK IYNNDVMKIF CPYKNCRFKL RSEHLKPYIS
QEMFDKFKAL RKIVFKRMNP NVRYCTRADC DGYMIGDEEH PKLTCKKCFQ EVCFHCCNNW
HQGLRCDQAI LEEETEDAQK EIGKQTCPMC NSKLNILQQI DGVQYSNKIM CSACNKPFCN
LCRRQCGQFH FAPWNICYGC PGQKYSLEEP QCCEKFCIFL WGVMKLMMYI FLSVIGLALY
PFIVAIVSLF MPLIIYAYFK GNRLQYSGFK KYLLLFSLFL LGIILYPVWL LITFIPGTCL
FFKDMYQEKR LYGNEIDASQ VNQ
//
