ID   Q23NL0_TETTS            Unreviewed;      1072 AA.
AC   Q23NL0;
DT   18-APR-2006, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 2.
DT   27-MAR-2024, entry version 65.
DE   SubName: Full=Cyclic nucleotide-binding domain protein {ECO:0000313|EMBL:EAR98064.2};
GN   ORFNames=TTHERM_00752100 {ECO:0000313|EMBL:EAR98064.2};
OS   Tetrahymena thermophila (strain SB210).
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR98064.2, ECO:0000313|Proteomes:UP000009168};
RN   [1] {ECO:0000313|Proteomes:UP000009168}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX   PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA   Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA   Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA   Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA   Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA   Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA   Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA   Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA   Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA   Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA   Hamilton E.P., Orias E.;
RT   "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT   model eukaryote.";
RL   PLoS Biol. 4:1620-1642(2006).
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DR   EMBL; GG662655; EAR98064.2; -; Genomic_DNA.
DR   RefSeq; XP_001018309.2; XM_001018309.2.
DR   AlphaFoldDB; Q23NL0; -.
DR   STRING; 312017.Q23NL0; -.
DR   EnsemblProtists; EAR98064; EAR98064; TTHERM_00752100.
DR   GeneID; 7846477; -.
DR   KEGG; tet:TTHERM_00752100; -.
DR   eggNOG; ENOG502SC32; Eukaryota.
DR   HOGENOM; CLU_275511_0_0_1; -.
DR   InParanoid; Q23NL0; -.
DR   OrthoDB; 5397097at2759; -.
DR   Proteomes; UP000009168; Unassembled WGS sequence.
DR   CDD; cd00038; CAP_ED; 1.
DR   Gene3D; 2.60.120.10; Jelly Rolls; 2.
DR   InterPro; IPR043533; CNBD1/2.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR018490; cNMP-bd_dom_sf.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   PANTHER; PTHR23011:SF28; CYCLIC NUCLEOTIDE-BINDING DOMAIN CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR23011; UNCHARACTERIZED; 1.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   SMART; SM00100; cNMP; 2.
DR   SUPFAM; SSF51206; cAMP-binding domain-like; 2.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009168}.
FT   DOMAIN          59..159
FT                   /note="Cyclic nucleotide-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50042"
FT   REGION          423..449
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          894..921
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          320..347
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1072 AA;  124400 MW;  1A554AE6113E1979 CRC64;
     MQHINNILEV LQKPPQKRTP RDIFLLQNET KSIQFFKQYN DSGDTDIHNK CCVSMKHQYM
     KKDQVVFHID TTGSKFYLIL EGTVGVYIRL PKKRQESEDN QQENTNQIDN DLVCVKELNA
     GTGFGELALM NNKPRLASII CHSNCHFATL DKKEFNEILK EKEEEKLIKE MGFFASLPFF
     KGWNFNLVKL LYLNSVRVNF VKGDRIYKEG SEPLAVYIIV SGEFVLEKSF YKDDSCDHLY
     KTSSQEVRHL MGSNKKASKQ FQISVYTNPE LFGDEEIMEG VDYRKCTAIC NSAQGQCILI
     KKRDFELRIM HEEGALNYLQ ERLAIKNERM KEKIESITKQ IMNYKNFIYD DPKDFKKQAE
     FQKIYRTQQG RQQLKLQSLS DLKEMIQTGQ DPAKKKKKYK ENSQPDINFL EEGLIKSQNE
     IQVNNSKEDE EQALSPSRVQ SPSKIQNAKD KSALKDHFLE MLQQHVNKQK KKETKNLMIS
     SQNFSKSQID LSQLEIRSSL LPSQQYQKFS SFQKFDGQEY SPTLHKINKS QVFLNQNEKN
     LSKTHLPSLN KMNNSAYDSS PLINPQISGE KFQKLKLQQT LMRPPNFVKQ YDNPDGEDDE
     KEIKKHKSMS RIYLTKQNSQ TKITLPTNHS QQENRRTKYN ILSQSQIDFR GSNNDLIDQT
     EIKTDQQEEN KIQQMRKQYQ KSGKSQSQQI YYNSLQIANE QLPYKIKIQG EDDANLISNY
     ETNSQTYNNN TNNKYNTQFS NEYIPNQIQS YTKQNTPDIY LNSPQINPLD NNKIENSIYL
     NHDQQILYQQ NNSNLIPSKS FNQIPSIQMI KNSKNEIDLM NLPLNGISDN SNFIPPLTAD
     PPHTNSIHKS TDCKNNNLSY RSISCIIQNN IKLLDPQKVD SLKKSSEYLN EQIRFQKTPQ
     KQANKSIAKN HPSSSKSPNK SNLYKFQIEY QASNAKKAEL KLDKQFQISK QNARIYEAIH
     HNPKTTKSTK DIFRDSQSTL IKSPKQKLLP IKAQFQIYPS SHQTSPIFSR QTDINTAYSE
     LNSPIQTQKQ LMLLNNNNKL RKSDFSLCTS DSSSNNNNNK IVINIQSSSQ NI
//