ID Q23RS4_TETTS Unreviewed; 1399 AA.
AC Q23RS4;
DT 18-APR-2006, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 2.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Cation channel family protein {ECO:0000313|EMBL:EAR99211.2};
GN ORFNames=TTHERM_01184150 {ECO:0000313|EMBL:EAR99211.2};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR99211.2, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
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DR EMBL; GG662642; EAR99211.2; -; Genomic_DNA.
DR RefSeq; XP_001019456.2; XM_001019456.2.
DR EnsemblProtists; EAR99211; EAR99211; TTHERM_01184150.
DR GeneID; 7824945; -.
DR KEGG; tet:TTHERM_01184150; -.
DR eggNOG; KOG0500; Eukaryota.
DR HOGENOM; CLU_255767_0_0_1; -.
DR InParanoid; Q23RS4; -.
DR OrthoDB; 52684at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.10.287.630; Helix hairpin bin; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR013099; K_chnl_dom.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR45689; I[[H]] CHANNEL, ISOFORM E; 1.
DR PANTHER; PTHR45689:SF5; I[[H]] CHANNEL, ISOFORM E; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF07885; Ion_trans_2; 1.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 4: Predicted;
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 392..413
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 419..440
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 461..480
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 492..508
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 529..554
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 601..618
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 625..643
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 733..834
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 179..227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 250..287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1118..1139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 179..203
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 210..227
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 250..272
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 273..287
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1399 AA; 164834 MW; 4B7FA5467B5B53C9 CRC64;
MKLNIQKLNF EKTQKQHDEM IEIFHQRMKE KTLTEDEFGT KGASLNRMQS SFQELSSKIF
QDNNLSIKIG NIGQIIDSKK RLQCNNEDSQ LEFIQSKIDI NYVQNDNFNI SAKDKKQLQN
SMTSSIQNVN QQPIFQDNPD NKSMVSSIQD LNSSCLNQNL SPTFRNRKKN NEQSDILGQQ
KKNQQLSGGS DIQSNQISSK AKIKQEDQQV REPSISINDK LDNNQDQTPL KLFNAKGRTF
KQNKQNESQF SGIGMENSNQ KQKQSQATFQ NENRKKQSRK FTEMPKKQKK TNFIHIIMKM
KSYAYKMASN IQSKKLAILQ RQKFFYLRDK TINYNKQEKE DFEFYDYNRF QKFILLIFQQ
TQSIFFAKRL LHRIPTIPLF LPQSIWKFVW DIFNMIIVIV FFFYLPLYFI YGIQFSTVFY
LQNLDIMLVI IATLDVFVNL NTVQYRKGNL LHSRSLILLE YFSKNGILNM LFVTILWIVV
ASQRIQIQLI QNYRFSIMFF AVALFKVFRQ NSFKNRIYDR FYLRKINRGF ISLMQIFFNL
FIVTHLFACI WLIVGKINQT EDSILCAQQN AYNNYKNCTY TWLDKLSGAQ NLTFYEQYLR
AYYFSTVTMI TVGYGDIIPV NSQEYLLSIL TMLIACGMFG YSLNSIGQIL SEMDINNKEY
DEHFNAIYGF MYKKNISTDL QVQVREYLQY FFIQSNQEDI QKQQKVISLL PDSLQNQIML
EANKIIFENS NLFKMNFSEQ IIQKTIKIIE QREFRPGQKI IVQDVENDNS IYFIEKGSVE
VYNSNNNEGL KLLHKGNQFG EIQFFTGQTS QLSVRSIEFT KLLAIKRSSF FELVQSSPLD
LERFCMIKDS ILINNKLDMV GIFCYCCKSS NHLVTQCSFI HLQQDKYKII KEYVKNDFQG
RDKDIQRRGY SYDSLQIKDQ IDESARQYVE ENIEELCTKG WFNDLVQQEY QNQLAQFKNS
YGNPSRTSLK NINQLQNQYY FQKTKTNQTL QKQLSNIKFQ YQKVKNTISN IQESQNMNTY
IELHPFDKSS AHIQPRSNNN FQHAFSGYND EFSQSLQAFN FNKKVQFSIN SLQENSNDDN
QTDNKSLQVQ QCQSQQVINY GNNPIGFHHY QSNLGDCSFT PSNRQRQQSN YSEKCTSPKS
TQNNILVNVN SANYYHQNNP QNTQASQNIQ CYNPQTSNYC INDILQQFAS FDSSKQININ
NQDTFSQVSY QNTQYDNQFY NRYKSQSKSP NQSDQQQRHK EYINSKENIK KSTLKSEIFN
KKVSINPLIL SKQLSNINQK YTNEALIKQL KELVQIPHNI NTQQENFLFD ILKSYQFYMP
QNNYERVILS FNVLMRKNQA NLSNQNTKKS LQKNKLKNIV KAQINKPIQF YKNLLKQNEL
ENKQQDSNIE ENHKNNSTQ
//
