ID Q240Q4_TETTS Unreviewed; 629 AA.
AC Q240Q4;
DT 18-APR-2006, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 3.
DT 27-MAR-2024, entry version 91.
DE SubName: Full=Xaa-pro aminopeptidase, putative {ECO:0000313|EMBL:EAS02360.3};
GN ORFNames=TTHERM_00624780 {ECO:0000313|EMBL:EAS02360.3};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAS02360.3, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
CC -!- SIMILARITY: Belongs to the peptidase M24B family.
CC {ECO:0000256|ARBA:ARBA00008766}.
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DR EMBL; GG662540; EAS02360.3; -; Genomic_DNA.
DR RefSeq; XP_001022605.3; XM_001022605.3.
DR AlphaFoldDB; Q240Q4; -.
DR STRING; 312017.Q240Q4; -.
DR EnsemblProtists; EAS02360; EAS02360; TTHERM_00624780.
DR GeneID; 7831671; -.
DR KEGG; tet:TTHERM_00624780; -.
DR eggNOG; KOG2413; Eukaryota.
DR HOGENOM; CLU_011781_2_1_1; -.
DR InParanoid; Q240Q4; -.
DR OrthoDB; 869at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR CDD; cd01085; APP; 1.
DR Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 2.
DR InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR InterPro; IPR000587; Creatinase_N.
DR InterPro; IPR000994; Pept_M24.
DR InterPro; IPR033740; Pept_M24B.
DR InterPro; IPR032416; Peptidase_M24_C.
DR PANTHER; PTHR43763; XAA-PRO AMINOPEPTIDASE 1; 1.
DR PANTHER; PTHR43763:SF6; XAA-PRO AMINOPEPTIDASE 1; 1.
DR Pfam; PF01321; Creatinase_N; 1.
DR Pfam; PF16189; Creatinase_N_2; 1.
DR Pfam; PF00557; Peptidase_M24; 1.
DR Pfam; PF16188; Peptidase_M24_C; 1.
DR SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 1.
PE 3: Inferred from homology;
KW Aminopeptidase {ECO:0000313|EMBL:EAS02360.3};
KW Hydrolase {ECO:0000313|EMBL:EAS02360.3};
KW Protease {ECO:0000313|EMBL:EAS02360.3};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168}.
FT DOMAIN 38..167
FT /note="Creatinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01321"
FT DOMAIN 356..559
FT /note="Peptidase M24"
FT /evidence="ECO:0000259|Pfam:PF00557"
FT DOMAIN 565..629
FT /note="Peptidase M24 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16188"
SQ SEQUENCE 629 AA; 70848 MW; 2ADFDD71BD96FCA4 CRC64;
MIQLLYQTLN KSFLQKKKIN QATYFSFCST IMSQKLVQIR SLMAQHGLKA YLVPHDDQHS
SEYIASSDER LAFISGFKGS AGLALISDTH AYLYTDSRYW IAASKQLEEG WELKKTGLGF
KTWFAEAAEQ QAGHKIGFDP LLIQADAVEN RTKYFQQHNI QFVSVSENLV DAVWTDKPAD
SLDKIFRHED KYVGQTAAEK IAVIGKELKN LGANYTLSAK LDEIAWILNL RGSDISFNPV
FKAYLILHYC FQTNTNKGTL YINDQKVPED IRQYLETIHI QIRPYTQIFT DVTTIDQKIA
IHKGEVNYKI LSSIPPQFVV EQTGTAIINR LKGVKTATQI QGFKTCNIRD GASLVSYLAW
LEHELVVKKS TQWTEYTASQ VLDNKRRANE LNVGLSFDTI SSTGPNGAVV HYRAEEATAL
TLNTNQIYLV DSGAQYHDGT TDTTRTVHFG TPTDEEKDAY TRVLLGNLDI QRVQWPASSR
IGGSDIDALA RKYLWQKGLD YGHGTGHGVG HFLNVHEGPH GISKFRSEPL VEGMIVTDEP
GYYKEGHFGI RIEDDLVVVK KPTEGFLGFE NLTLVPYDRN LIDLSLLTQA DKDYINAYHQ
KVRSLLAPLL ESQNDQIGLA YLNKKTAEL
//
