ID Q25439_MUSDO Unreviewed; 2105 AA.
AC Q25439; P91760;
DT 01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT 01-JAN-1998, sequence version 2.
DT 27-MAR-2024, entry version 128.
DE RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EMBL:AAB47604.1};
RN [1] {ECO:0000313|EMBL:AAB47604.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NAIDM {ECO:0000313|EMBL:AAB47604.1};
RX PubMed=8146143; DOI=10.1073/pnas.91.7.2483;
RA Knipple D.C., Doyle K.E., Marsella-Herrick P.A., Soderlund D.M.;
RT "Tight genetic linkage between the kdr insecticide resistance trait and a
RT voltage-sensitive sodium channel gene in the house fly.";
RL Proc. Natl. Acad. Sci. U.S.A. 91:2483-2487(1994).
RN [2] {ECO:0000313|EMBL:AAB47604.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NAIDM {ECO:0000313|EMBL:AAB47604.1};
RX PubMed=8814780; DOI=10.1016/0965-1748(95)00093-3;
RA Ingles P.J., Adams P.M., Knipple D.C., Soderlund D.M.;
RT "Characterization of voltage-sensitive sodium channel gene coding sequences
RT from insecticide-susceptible and knockdown-resistant house fly strains.";
RL Insect Biochem. Mol. Biol. 26:319-326(1996).
RN [3] {ECO:0000313|EMBL:AAB47604.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NAIDM {ECO:0000313|EMBL:AAB47604.1};
RA Ingles P.J., Adams P.M., Knipple D.C., Soderlund D.M.;
RL Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability of
CC excitable membranes. Assuming opened or closed conformations in
CC response to the voltage difference across the membrane, the protein
CC forms a sodium-selective channel through which Na(+) ions may pass in
CC accordance with their electrochemical gradient.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR EMBL; U38813; AAB47604.1; -; mRNA.
DR PIR; A53461; A53461.
DR PIR; S72488; S72488.
DR SMR; Q25439; -.
DR VEuPathDB; VectorBase:MDOA002080; -.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR CDD; cd13433; Na_channel_gate; 1.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR031649; GPHH_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR001696; Na_channel_asu.
DR InterPro; IPR044564; Na_chnl_inactivation_gate.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR024583; Na_trans_cytopl.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF288; SODIUM CHANNEL PROTEIN; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF16905; GPHH; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR Pfam; PF06512; Na_trans_assoc; 1.
DR Pfam; PF11933; Na_trans_cytopl; 1.
DR PRINTS; PR00170; NACHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU361132};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361132};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361132};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU361132};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU361132};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361132};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361132};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU361132}.
FT TRANSMEM 134..161
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 205..227
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 239..257
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 263..285
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 395..417
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 796..819
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 928..947
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1002..1025
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1328..1347
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1354..1377
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1418..1441
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1522..1548
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1609..1626
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1642..1660
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1672..1691
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1735..1759
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1820..1844
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT DOMAIN 1865..1900
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 35..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 521..579
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 663..694
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1127..1149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1168..1211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1989..2066
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 421..470
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 35..51
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 521..559
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 667..685
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1168..1182
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1183..1211
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2105 AA; 236487 MW; 7F3F54BFD20C16E6 CRC64;
MTEDSDSISE EERSLFRPFT RESLLQIEQR IAEHEKQKEL ERKRAAEGEQ IRYDDEDEDE
GPQPDPTLEQ GVPIPVRMQG SFPPELASTP LEDIDPFYSN VLTFVVISKG KDIFRFSASK
AMWLLDPFNP IRRVAIYILV HPLFSLFIIT TILTNCILMI MPTTPTVEST EVIFTGIYTF
ESAVKVMARG FILCPFTYLR DAWNWLDFVV IALAYVTMGI DLGNLAALRT FRVLRALKTV
AIVPGLKTIV GAVIESVKNL RDVIILTMFS LSVFALMGLQ IYMGVLTQKC IKRFPLDGSW
GNLTDENWFL HNSNSSNWFT ENDGESYPVC GNVSGAGQCG EDYVCLQGFG PNPNYDYTSF
DSFGWAFLSA FRLMTQDFWE DLYQHVLQAA GPWHMLFFIV IIFLGSFYLV NLILAIVAMS
YDELQKKAEE EEAAEEEAIR EAEEAAAAKA AKLEERANVA AQAAQDAADA AAAALHPEMA
KSPTYSCISY ELFVGGEKGN DDNNKEKMSI RSVEVESESV SVIQRQPAPT TAPATKVRKV
STTSLSLPGS PFNLRRGSRS SHKYTIRNGR GRFGIPGSDR KPLVLQTYQD AQQHLPYADD
SNAVTPMSEE NGAIIVPAYY CNLGSRHSSY TSHQSRISYT SHGDLLGGMA AMGASTMTKE
SKLRSRNTRN QSIGAATNGG SSTAGGGYPD ANHKEQRDYE MGQDYTDEAG KIKHHDNPFI
EPVQTQTVVD MKDVMVLNDI IEQAAGRHSR ASERGEDDDE DGPTFKDIAL EYILKGIEIF
CVWDCCWVWL KFQEWVSFIV FDPFVELFIT LCIVVNTMFM AMDHHDMNPE LEKVLKSGNY
FFTATFAIEA SMKLMAMSPK YYFQEGWNIF DFIIVALSLL ELGLEGVQGL SVLRSFRLLR
VFKLAKSWPT LNLLISIMGR TMGALGNLTF VLCIIIFIFA VMGMQLFGKN YIDHKDRFKD
HELPRWNFTD FMHSFMIVFR VLCGEWIESM WDCMYVGDVS CIPFFLATVV IGNLVVLNLF
LALLLSNFGS SSLSAPTADN DTNKIAEAFN RIARFKNWVK RNIADCFKLI RNKLTNQISD
QPSEHGDNEL ELGHDEIMGD GLIKKGMKGE TQLEVAIGDG MEFTIHGDMK NNKPKKSKFM
NNTTMIGNSI NHQDNRLEHE LNHRGLSIQD DDTASINSYG SHKNRPFKDE SHKGSAETIE
GEEKRDVSKE DLGLDEELDE EAEGDEGQLD GDIIIHAQND DEIIDDYPAD CFPDSYYKKF
PILAGDEDSP FWQGWGNLRL KTFQLIENKY FETAVITMIL MSSLALALED VHLPDRPVMQ
DILYYMDRIF TVIFFLEMLI KWLALGFKVY FTNAWCWLDF VIVMLSLINL VAVWSGLNDI
AVFRSMRTLR ALRPLRAVSR WEGMKVVVNA LVQAIPSIFN VLLVCLIFWL IFAIMGVQLF
AGKYFKCKDG NDTVLSHEII PNRNACKSEN YTWENSAMNF DHVGNAYLCL FQVATFKGWI
QIMNDAIDSR EVDKQPIRET NIYMYLYFVF FIIFGSFFTL NLFIGVIIDN FNEQKKKAGG
SLEMFMTEDQ KKYYNAMKKM GSKKPLKAIP RPRWRPQAIV FEIVTDKKFD IIIMLFIGLN
MFTMTLDRYD ASEAYNNVLD KLNGIFVVIF SGECLLKIFA LRYHYFKEPW NLFDVVVVIL
SILGLVLSDI IEKYFVSPTL LRVVRVAKVG RVLRLVKGAK GIRTLLFALA MSLPALFNIC
LLLFLVMFIF AIFGMSFFMH VKEKSGINAV YNFKTFGQSM ILLFQMSTSA GWDGVLDAII
NEEDCDPPDN DKGYPGNCGS ATVGITFLLS YLVISFLIVI NMYIAVILEN YSQATEDVQE
GLTDDDYDMY YEIWQQFDPE GTQYIRYDQL SEFLDVLEPP LQIHKPNKYK IISMDMPICR
GDMMYCVDIL DALTKDFFAR KGNPIEETGE IGEIAARPDT EGYDPVSSTL WRQREEYCAK
LIQNAWRRYK NGPPQEGDEG EAAGGEDGAE GGEGEGGSGG GGGDDGGSAT GATAAAGATS
PSDPDAGEAD GASVGGPLSP GCVSGGSNGR QTAVLVESDG FVTKNGHKVV IHSRSPSITS
RTADV
//
