ID Q25659_9APIC Unreviewed; 379 AA.
AC Q25659;
DT 01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT 01-NOV-1996, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=Merozoite surface protein 1 {ECO:0000256|ARBA:ARBA00022062};
DE AltName: Full=Merozoite surface antigen {ECO:0000256|ARBA:ARBA00031689};
DE AltName: Full=PMMSA {ECO:0000256|ARBA:ARBA00032276};
DE Flags: Fragment;
GN Name=MSP1 {ECO:0000313|EMBL:AAC46960.1};
OS Plasmodium cynomolgi.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX NCBI_TaxID=5827 {ECO:0000313|EMBL:AAC46960.1};
RN [1] {ECO:0000313|EMBL:AAC46960.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Ceylonesis {ECO:0000313|EMBL:AAC46960.1};
RX PubMed=8719250; DOI=10.1016/0166-6851(95)02477-8;
RA Longacre S.;
RT "The Plasmodium cynomolgi merozoite surface protein 1 C-terminal sequence
RT and its homologies with other Plasmodium species.";
RL Mol. Biochem. Parasitol. 74:105-111(1995).
RN [2] {ECO:0000313|EMBL:AAC46960.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Ceylonesis {ECO:0000313|EMBL:AAC46960.1};
RA Thiaucourt F.;
RL Submitted (APR-1995) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0007829|PDB:1B9W}
RP X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 291-379, AND DISULFIDE BONDS.
RX PubMed=10230398; DOI=10.1016/S1097-2765(00)80473-6;
RA Chitarra V., Holm I., Bentley G.A., Petres S., Longacre S.;
RT "The crystal structure of C-terminal merozoite surface protein 1 at 1.8 A
RT resolution, a highly protective malaria vaccine candidate.";
RL Mol. Cell 3:457-464(1999).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004609};
CC Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}. Membrane
CC {ECO:0000256|ARBA:ARBA00004589}; Lipid-anchor, GPI-anchor
CC {ECO:0000256|ARBA:ARBA00004589}.
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DR EMBL; U25743; AAC46960.1; -; Genomic_DNA.
DR PDB; 1B9W; X-ray; 1.80 A; A=291-379.
DR PDBsum; 1B9W; -.
DR AlphaFoldDB; Q25659; -.
DR SMR; Q25659; -.
DR EvolutionaryTrace; Q25659; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR InterPro; IPR010901; MSP1_C.
DR InterPro; IPR024730; MSP1_EGF_1.
DR Pfam; PF12946; EGF_MSP1_1; 1.
DR Pfam; PF07462; MSP1_C; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:1B9W}; Coiled coil {ECO:0000256|SAM:Coils};
KW Merozoite {ECO:0000313|EMBL:AAC46960.1};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 1..226
FT /note="Merozoite surface 1 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07462"
FT DOMAIN 297..332
FT /note="Merozoite surface protein EGF"
FT /evidence="ECO:0000259|Pfam:PF12946"
FT COILED 139..173
FT /evidence="ECO:0000256|SAM:Coils"
FT DISULFID 297..308
FT /evidence="ECO:0007829|PDB:1B9W"
FT DISULFID 320..331
FT /evidence="ECO:0007829|PDB:1B9W"
FT DISULFID 339..352
FT /evidence="ECO:0007829|PDB:1B9W"
FT DISULFID 346..362
FT /evidence="ECO:0007829|PDB:1B9W"
FT DISULFID 364..378
FT /evidence="ECO:0007829|PDB:1B9W"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAC46960.1"
FT NON_TER 379
FT /evidence="ECO:0000313|EMBL:AAC46960.1"
SQ SEQUENCE 379 AA; 43200 MW; A31A87E4B6C31FF7 CRC64;
DQVTTGEAES EAPEIIVPQG INEYDVVYIK PLAGMYKTIK KPLENHVNAL NTNIIDMLDS
RLKKRNYFLD VLNSDLNPYS IPHSGEYIIK DPYKLLDLEK KKLLGSYKYI GASVDKDMVT
ANDGLAYYQK MGDLYKKHLD EVNAQIKEVE ANINKHDEEI KKIGSEASKA NDKNQLNAKK
EELQKYLPFL SSIQKEYSTL VNKVHSYTDT LKKIINNCQI EKKETETIVN KLEDYSKMDE
ELDVYKQSKK EDDVKSSGLL EKLMNSKLIN QEESKKALSE LLNVQTQMLN MSSEHRCIDT
NVPENAACYR YLDGTEEWRC LLYFKEDAGK CVPAPNMTCK DKNGGCAPEA ECKMNDKNEI
VCKCTKEGSE PLFEGVFCS
//
