ID Q26593_SCHMA Unreviewed; 482 AA.
AC Q26593;
DT 01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT 01-NOV-1996, sequence version 1.
DT 27-MAR-2024, entry version 149.
DE RecName: Full=Protein disulfide-isomerase {ECO:0000256|ARBA:ARBA00012723, ECO:0000256|RuleBase:RU361130};
DE EC=5.3.4.1 {ECO:0000256|ARBA:ARBA00012723, ECO:0000256|RuleBase:RU361130};
OS Schistosoma mansoni (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6183 {ECO:0000313|EMBL:CAA80520.1};
RN [1] {ECO:0000313|EMBL:CAA80520.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liberia {ECO:0000313|EMBL:CAA80520.1};
RX PubMed=8078516; DOI=10.1016/0166-6851(94)90141-4;
RA Finken M., Sobek A., Symmons P., Kunz W.;
RT "Characterization of the complete protein disulfide isomerase gene of
RT Schistosoma mansoni and identification of the tissues of its expression.";
RL Mol. Biochem. Parasitol. 64:135-144(1994).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Catalyzes the rearrangement of -S-S- bonds in proteins.;
CC EC=5.3.4.1; Evidence={ECO:0000256|ARBA:ARBA00001182,
CC ECO:0000256|RuleBase:RU361130};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum lumen
CC {ECO:0000256|ARBA:ARBA00004319}.
CC -!- SIMILARITY: Belongs to the protein disulfide isomerase family.
CC {ECO:0000256|ARBA:ARBA00006347, ECO:0000256|RuleBase:RU004208}.
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DR EMBL; Z22933; CAA80520.1; -; Genomic_DNA.
DR PIR; S34275; S34275.
DR AlphaFoldDB; Q26593; -.
DR HOGENOM; CLU_025879_1_0_1; -.
DR ExpressionAtlas; Q26593; baseline.
DR GO; GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
DR GO; GO:0003756; F:protein disulfide isomerase activity; IEA:UniProtKB-EC.
DR CDD; cd02961; PDI_a_family; 1.
DR CDD; cd02995; PDI_a_PDI_a'_C; 1.
DR CDD; cd02982; PDI_b'_family; 1.
DR CDD; cd02981; PDI_b_family; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 4.
DR InterPro; IPR005788; PDI_thioredoxin-like_dom.
DR InterPro; IPR005792; Prot_disulphide_isomerase.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR017937; Thioredoxin_CS.
DR InterPro; IPR013766; Thioredoxin_domain.
DR NCBIfam; TIGR01130; ER_PDI_fam; 1.
DR NCBIfam; TIGR01126; pdi_dom; 2.
DR PANTHER; PTHR18929; PROTEIN DISULFIDE ISOMERASE; 1.
DR PANTHER; PTHR18929:SF246; PROTEIN DISULFIDE-ISOMERASE; 1.
DR Pfam; PF00085; Thioredoxin; 2.
DR Pfam; PF13848; Thioredoxin_6; 1.
DR PRINTS; PR00421; THIOREDOXIN.
DR SUPFAM; SSF52833; Thioredoxin-like; 4.
DR PROSITE; PS00194; THIOREDOXIN_1; 2.
DR PROSITE; PS51352; THIOREDOXIN_2; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR605792-51};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|RuleBase:RU361130};
KW Redox-active center {ECO:0000256|ARBA:ARBA00023284,
KW ECO:0000256|PIRSR:PIRSR605792-51}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU361130}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|RuleBase:RU361130"
FT CHAIN 22..482
FT /note="Protein disulfide-isomerase"
FT /evidence="ECO:0000256|RuleBase:RU361130"
FT /id="PRO_5005142827"
FT DOMAIN 5..177
FT /note="Thioredoxin"
FT /evidence="ECO:0000259|PROSITE:PS51352"
FT DOMAIN 328..467
FT /note="Thioredoxin"
FT /evidence="ECO:0000259|PROSITE:PS51352"
FT DISULFID 52..55
FT /note="Redox-active"
FT /evidence="ECO:0000256|PIRSR:PIRSR605792-51"
FT DISULFID 391..394
FT /note="Redox-active"
FT /evidence="ECO:0000256|PIRSR:PIRSR605792-51"
SQ SEQUENCE 482 AA; 54155 MW; EA2DE2E2BB209658 CRC64;
MKLSVALVVV FLVFAASEVT EEDDVLVLNK KNFDDVIKTN KFVLVEFYAP WCGHCKALAP
EYSEAAKKLK EKGSLIKLAK VDATVEEELA LKHGEKGYPT LKFFRNEQPI DFLGERDSDA
IVNWCLRKSK PSVEYIDSLD SCKQFIDKAN IAILGFIKDT DSLDLADFEK VADELDDAGF
AIANSSEILT EYGITQTPKI VLFKNFDENR VEYTGGTLEN LKHFIQVESV PLVSEFSQKT
AGVVFGSPIQ KHIVFFLSKS TDHSDLVDKL TEVARQFKGK LHVIYVDVDV ENNLRVLEFF
GLSKNDAPTY RIIELGEETT KYKPDTNDYS VSAMSDFVQR TIDGKVKPFL MSEEIPSDQT
GAVKVLVGKN YNDVVKDKSK DVFVKLYAPW CGHCKALAPV WDELGETFKN SDTVIAKMDA
TVNEVEDLKV TSFPTLKFYP KNSEEVIDYT GDRSFEALKK FVESGGKSSE ATKQEDQIKD
EL
//
