ID Q26GD2_FLABB Unreviewed; 554 AA.
AC Q26GD2;
DT 18-APR-2006, integrated into UniProtKB/TrEMBL.
DT 18-APR-2006, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=DNA ligase (ATP) {ECO:0000256|ARBA:ARBA00012727};
DE EC=6.5.1.1 {ECO:0000256|ARBA:ARBA00012727};
GN ORFNames=BBFL7_01826 {ECO:0000313|EMBL:EAS20934.1};
OS Flavobacteria bacterium (strain BBFL7).
OC Bacteria; Bacteroidota; Flavobacteriia.
OX NCBI_TaxID=156586 {ECO:0000313|EMBL:EAS20934.1, ECO:0000313|Proteomes:UP000002172};
RN [1] {ECO:0000313|EMBL:EAS20934.1, ECO:0000313|Proteomes:UP000002172}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BBFL7 {ECO:0000313|EMBL:EAS20934.1,
RC ECO:0000313|Proteomes:UP000002172};
RA Azam F., Beardsley C., Gaasterland T., Malfatti F., Mayali X., Podell S.,
RA Samo T., Smriga S., Ferriera S., Johnson J., Kravitz S., Halpern A.,
RA Remington K., Beeson K., Tran B., Rogers Y.-H., Friedman R., Venter J.C.;
RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-
CC (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP +
CC diphosphate.; EC=6.5.1.1; Evidence={ECO:0000256|ARBA:ARBA00034003};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAS20934.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAPD01000001; EAS20934.1; -; Genomic_DNA.
DR AlphaFoldDB; Q26GD2; -.
DR STRING; 156586.BBFL7_01826; -.
DR HOGENOM; CLU_005138_6_2_10; -.
DR OrthoDB; 9767858at2; -.
DR Proteomes; UP000002172; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd07897; Adenylation_DNA_ligase_Bac1; 1.
DR CDD; cd07972; OBF_DNA_ligase_Arch_LigB; 1.
DR Gene3D; 1.10.3260.10; DNA ligase, ATP-dependent, N-terminal domain; 1.
DR Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR026333; ATP_dep_DNA_lig_pp_1105_fam.
DR InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR InterPro; IPR036599; DNA_ligase_N_sf.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR NCBIfam; TIGR04120; DNA_lig_bact; 1.
DR PANTHER; PTHR45674; DNA LIGASE 1/3 FAMILY MEMBER; 1.
DR PANTHER; PTHR45674:SF13; DNA LIGASE-RELATED; 1.
DR Pfam; PF04679; DNA_ligase_A_C; 1.
DR Pfam; PF01068; DNA_ligase_A_M; 1.
DR Pfam; PF04675; DNA_ligase_A_N; 1.
DR SUPFAM; SSF117018; ATP-dependent DNA ligase DNA-binding domain; 1.
DR SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:EAS20934.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002172}.
FT DOMAIN 303..452
FT /note="ATP-dependent DNA ligase family profile"
FT /evidence="ECO:0000259|PROSITE:PS50160"
SQ SEQUENCE 554 AA; 64096 MW; 740CE72C843DDFB7 CRC64;
MKQFAELIRI IDGTNKTTLK VAALTEYFKT APEEDKLWTI AILSHRRPKR PVNTTLMREW
ATEISGIPLW LFEESYHIVG DLAETIALIL PTTNKSSDKS LSQIIKELID LRKKEDEDKK
KYLQENWLKL NYYERFVFNK IMTGGFRIGV SQKLMTRALS QATDIDQDIL AHKLMGSWTG
ENTTFQELVY QDNEVAMRGK PYPFYLAYAI ENEAADLGDV TQWSAEHKWD GIRSQTIIRA
GELFVWSRGE ELVTDKYPEF QKFLEVIPDG TVIDGEILPY KNGQILNFND LQTRIGRKTV
GKKLLTDVPV VIVAYDLLEW QGEDIRERSF QERRAILDQL VDHIHEKEKQ EELDDKSISD
SSSTTIPLLI SETMSFSSWE EVAQERERSA ERKSEGLMLK RKDSPYLVGR KKGDWWKWKV
DPFTIDAVLT YAMRGHGRRA NLYTDYTFGL WNDGELVTFA KAYSGLTDAE FRKIDAWIKK
NTLERFGPVR SVTPHHVFEI AFEGIAPSKR HKSGVATRFP RIHRWRKDKP IEEANTLEDL
KALIPTDGGF LKDD
//
