ID Q28CM4_XENTR Unreviewed; 888 AA.
AC Q28CM4;
DT 04-APR-2006, integrated into UniProtKB/TrEMBL.
DT 04-APR-2006, sequence version 1.
DT 27-MAR-2024, entry version 105.
DE RecName: Full=Origin recognition complex subunit 1 {ECO:0000256|ARBA:ARBA00019081, ECO:0000256|RuleBase:RU365058};
GN Name=orc1 {ECO:0000313|RefSeq:NP_001039194.1,
GN ECO:0000313|Xenbase:XB-GENE-997997};
GN Synonyms=orc1l {ECO:0000313|EMBL:CAJ83639.1,
GN ECO:0000313|RefSeq:NP_001039194.1};
GN ORFNames=TEgg001i08.1-001 {ECO:0000313|EMBL:CAJ83639.1};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|EMBL:CAJ83639.1};
RN [1] {ECO:0000313|RefSeq:NP_001039194.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:CAJ83639.1}
RP NUCLEOTIDE SEQUENCE.
RA Amaya E., Ashurst J.L., Bonfield J.K., Croning M.D.R., Chen C-K.,
RA Davies R.M., Francis M.D., Garrett N., Gilchrist M.J., Grafham D.V.,
RA McLaren S.R., Papalopulu N., Rogers J., Smith J.C., Taylor R.G., Voigt J.,
RA Zorn A.M.;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:NP_001039194.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the origin recognition complex (ORC) that binds
CC origins of replication. DNA-binding is ATP-dependent, however specific
CC DNA sequences that define origins of replication have not been
CC identified so far. ORC is required to assemble the pre-replication
CC complex necessary to initiate DNA replication.
CC {ECO:0000256|RuleBase:RU365058}.
CC -!- SUBUNIT: ORC is composed of six subunits.
CC {ECO:0000256|RuleBase:RU365058}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU365058}.
CC -!- SIMILARITY: Belongs to the ORC1 family. {ECO:0000256|ARBA:ARBA00008398,
CC ECO:0000256|RuleBase:RU365058}.
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DR EMBL; CR926304; CAJ83639.1; -; mRNA.
DR RefSeq; NP_001039194.1; NM_001045729.1.
DR GeneID; 734048; -.
DR KEGG; xtr:734048; -.
DR AGR; Xenbase:XB-GENE-997997; -.
DR CTD; 4998; -.
DR Xenbase; XB-GENE-997997; orc1.
DR OMA; CKQHLLG; -.
DR OrthoDB; 118994at2759; -.
DR Proteomes; UP000008143; Chromosome 4.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd04719; BAH_Orc1p_animal; 1.
DR CDD; cd08768; Cdc6_C; 1.
DR Gene3D; 2.30.30.490; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041083; AAA_lid_10.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR001025; BAH_dom.
DR InterPro; IPR043151; BAH_sf.
DR InterPro; IPR015163; Cdc6_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10763; CELL DIVISION CONTROL PROTEIN 6-RELATED; 1.
DR PANTHER; PTHR10763:SF23; ORIGIN RECOGNITION COMPLEX SUBUNIT 1; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF17872; AAA_lid_10; 1.
DR Pfam; PF01426; BAH; 1.
DR Pfam; PF09079; Cdc6_C; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00439; BAH; 1.
DR SMART; SM01074; Cdc6_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51038; BAH; 1.
PE 2: Evidence at transcript level;
KW ATP-binding {ECO:0000256|RuleBase:RU365058};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|RuleBase:RU365058};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU365058};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU365058};
KW Nucleus {ECO:0000256|RuleBase:RU365058};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143}.
FT DOMAIN 45..170
FT /note="BAH"
FT /evidence="ECO:0000259|PROSITE:PS51038"
FT REGION 207..271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 291..336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 360..512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..237
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 238..267
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 313..330
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 364..406
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 423..462
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 470..501
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 888 AA; 100202 MW; 02E5AD4B292CF0FA CRC64;
MTKYFTRVKK YRVYAWKGRP SIKDRKLLNL HYGGLDIKSE GTGYITVTPG DFVLIEGENE
ERPFVAKLQE LYDDGNEKHT SKHAIVQWFL RYEEVPYRKR ALLGREPHQQ EIFLYDVPSC
ENDIDAETII GRVEVTQLKP EDSFPVQKDA GSLFVKLSWN GKAFKPLTSN VCHNDGVIAA
NHDLEDHNSL PKPLFYPLEG DIAESKQITR SASRGQKNEA EVESRHSASK SSHCKERGVQ
RVSTTSTPGA RKKLQLSSPT KSGVPGLEQK DNTLDEEFKI LESIAPKRKV AFSGIPDSPP
KKVNGDTPRS TGILPLKGNT NSQTTRHSLR LTPMRRPLEQ LYGSLPKDQS LGKICIEANG
NKAADNERPV KSKTPQKLEP TPKKSTSRPS KRSEEDFEEE PQTPRSRRTS ARMTANKVRA
QLKALMDSDE DVDEDKDFVP IKETCTPSDS EEENEQEQVP LKRNVKKGCA TPRTPTSSRK
ASSRTPNKTP NSKTPHSATP RIPERNQPVK KPSNMLEEAR IRLHVSAVPE SLPCREQEYQ
DVYNFVESKL LDGTGGCMYI SGVPGTGKTA TVHEVIRSLQ ESAEEEELPS FQYIEINGMK
LTDPHQAYVQ ILKLLTGQKA TADHAAALLE KRFSTPASKK ETTVLLVDEL DLLWTRKQNV
MYSLFDWPTR KHAKLIVLAI ANTMDLPERI MMNRVASRLG LTRMSFQPYT HKQLQQIITS
RLNHIKAFGD DAIQLVARKV AALSGDARRC LDICRRATEI CEFSCKMGDS SLVKMSHVME
ALEEMFSSPY VTAIRNSSLM EQTFLRAVIA EFRRSGLEEA TFQQIYRQHV VLCRIEGLQP
PLMSETMAVC HRLGASRLLL VESSRNDLHL RVRINVSQDD IMYALKEE
//
