ID Q28IN6_XENTR Unreviewed; 299 AA.
AC Q28IN6;
DT 04-APR-2006, integrated into UniProtKB/TrEMBL.
DT 04-APR-2006, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Novel protein similar to fucolectin {ECO:0000313|EMBL:CAJ82872.1, ECO:0000313|RefSeq:NP_001037891.1};
GN Name=LOC733482 {ECO:0000313|RefSeq:NP_001037891.1,
GN ECO:0000313|Xenbase:XB-GENE-29099023};
GN ORFNames=TNeu022o02.1-001 {ECO:0000313|EMBL:CAJ82872.1};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|EMBL:CAJ82872.1};
RN [1] {ECO:0000313|EMBL:CAJ82872.1}
RP NUCLEOTIDE SEQUENCE.
RA Amaya E., Ashurst J.L., Bonfield J.K., Croning M.D.R., Chen C-K.,
RA Davies R.M., Francis M.D., Garrett N., Gilchrist M.J., Grafham D.V.,
RA McLaren S.R., Papalopulu N., Rogers J., Smith J.C., Taylor R.G., Voigt J.,
RA Zorn A.M.;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|RefSeq:NP_001037891.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Acts as a defensive agent. Recognizes blood group fucosylated
CC oligosaccharides including A, B, H and Lewis B-type antigens. Does not
CC recognize Lewis A antigen and has low affinity for monovalent haptens.
CC {ECO:0000256|ARBA:ARBA00002219}.
CC -!- SUBUNIT: Homotrimer. {ECO:0000256|ARBA:ARBA00011233}.
CC -!- SIMILARITY: Belongs to the fucolectin family.
CC {ECO:0000256|ARBA:ARBA00010147}.
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DR EMBL; CR760302; CAJ82872.1; -; mRNA.
DR RefSeq; NP_001037891.1; NM_001044426.1.
DR CAZy; CBM47; Carbohydrate-Binding Module Family 47.
DR GeneID; 733482; -.
DR KEGG; xtr:733482; -.
DR Xenbase; XB-GENE-29099023; LOC733482.
DR OMA; CTHTITE; -.
DR OrthoDB; 3970515at2759; -.
DR Proteomes; UP000008143; Chromosome 6.
DR GO; GO:0042806; F:fucose binding; IEA:UniProt.
DR GO; GO:0010185; P:regulation of cellular defense response; IEA:UniProt.
DR GO; GO:0001868; P:regulation of complement activation, lectin pathway; IEA:UniProt.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 2.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR006585; FTP1.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR PANTHER; PTHR45713; FTP DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45713:SF12; FUCOLECTIN TACHYLECTIN-4 PENTRAXIN-1 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00754; F5_F8_type_C; 2.
DR SMART; SM00607; FTP; 2.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 2.
PE 2: Evidence at transcript level;
KW Lectin {ECO:0000256|ARBA:ARBA00022734};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Signal {ECO:0000256|SAM:SignalP, ECO:0000313|RefSeq:NP_001037891.1}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..299
FT /evidence="ECO:0000256|SAM:SignalP,
FT ECO:0000313|RefSeq:NP_001037891.1"
FT /id="PRO_5033206268"
FT DOMAIN 23..162
FT /note="Fucolectin tachylectin-4 pentraxin-1"
FT /evidence="ECO:0000259|SMART:SM00607"
FT DOMAIN 163..299
FT /note="Fucolectin tachylectin-4 pentraxin-1"
FT /evidence="ECO:0000259|SMART:SM00607"
SQ SEQUENCE 299 AA; 33605 MW; 76F390EC2DE43D47 CRC64;
MKCFVVLLVC ISIGWVHSCK IRQEEISLIK GATATQSSTY RPDYAAEKAI DGISDYNMMR
HPCAQTRREH SPWWQLDLKY NYRVDSVVIV NRRDCCFHTL LGAQIRIGNS PDNNNPVCGI
ITDVFRPINL CCNGMEGRYV SVVIPGREEE LTLCEVKVYG EDNIARLGEA TQSSTYRPEY
NAVTAIDGDR NPDMMAGSCS LTGNDNPAWW QLDLKKRYKV GRVVILNRED CCSERLLGAE
VRVGDSSDNN NPVCGTVTNL SKETITVSCH GKEGQYVSVV IPGREEYLQL CEVEVYEQE
//
