UniProt: Q28JI2

Database: UniProt
Entry: Q28JI2_JANSC

LinkDB:  Q28JI2_JANSC 
Original site:  Q28JI2_JANSC

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Ontology (3)   
   GO (3)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (1)   
   KEGG GENES (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (9)   
   InterPro (7)   
   Pfam (2)   
Literature (1)   
   PubMed (1)   
All databases (17)   

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ID   Q28JI2_JANSC            Unreviewed;       470 AA.
AC   Q28JI2;
DT   04-APR-2006, integrated into UniProtKB/TrEMBL.
DT   04-APR-2006, sequence version 1.
DT   27-MAR-2024, entry version 91.
DE   RecName: Full=mannose-1-phosphate guanylyltransferase {ECO:0000256|ARBA:ARBA00012387};
DE            EC=2.7.7.13 {ECO:0000256|ARBA:ARBA00012387};
GN   OrderedLocusNames=Jann_4214 {ECO:0000313|EMBL:ABD57130.1};
OS   Jannaschia sp. (strain CCS1).
OG   Plasmid pCCS1 {ECO:0000313|Proteomes:UP000008326}.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC   Roseobacteraceae; Jannaschia.
OX   NCBI_TaxID=290400 {ECO:0000313|EMBL:ABD57130.1, ECO:0000313|Proteomes:UP000008326};
RN   [1] {ECO:0000313|Proteomes:UP000008326}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CCS1 {ECO:0000313|Proteomes:UP000008326};
RC   PLASMID=pCCS1 {ECO:0000313|Proteomes:UP000008326};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D.,
RA   Han C., Tapia R., Gilna P., Chertkov O., Saunders E., Schmutz J.,
RA   Larimer F., Land M., Kyrpides N., Lykidis A., Moran M.A., Belas R., Ye W.,
RA   Buchan A., Gonzalez J.M., Schell M.A., Richardson P.;
RT   "Complete sequence of plasmid 1 of Jannaschia sp. CCS1.";
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ABD57130.1, ECO:0000313|Proteomes:UP000008326}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CCS1 {ECO:0000313|EMBL:ABD57130.1,
RC   ECO:0000313|Proteomes:UP000008326};
RC   PLASMID=pCCS1 {ECO:0000313|Proteomes:UP000008326};
RX   PubMed=17526795; DOI=10.1128/AEM.02580-06;
RA   Moran M.A., Belas R., Schell M.A., Gonzalez J.M., Sun F., Sun S.,
RA   Binder B.J., Edmonds J., Ye W., Orcutt B., Howard E.C., Meile C.,
RA   Palefsky W., Goesmann A., Ren Q., Paulsen I., Ulrich L.E., Thompson L.S.,
RA   Saunders E., Buchan A.;
RT   "Ecological genomics of marine Roseobacters.";
RL   Appl. Environ. Microbiol. 73:4559-4569(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-mannose 1-phosphate + GTP + H(+) = diphosphate + GDP-
CC         alpha-D-mannose; Xref=Rhea:RHEA:15229, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57527,
CC         ChEBI:CHEBI:58409; EC=2.7.7.13;
CC         Evidence={ECO:0000256|ARBA:ARBA00001083};
CC   -!- SIMILARITY: Belongs to the mannose-6-phosphate isomerase type 2 family.
CC       {ECO:0000256|ARBA:ARBA00006115, ECO:0000256|RuleBase:RU004190}.
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DR   EMBL; CP000265; ABD57130.1; -; Genomic_DNA.
DR   RefSeq; WP_011453056.1; NC_007801.1.
DR   AlphaFoldDB; Q28JI2; -.
DR   KEGG; jan:Jann_4214; -.
DR   eggNOG; COG0662; Bacteria.
DR   eggNOG; COG0836; Bacteria.
DR   HOGENOM; CLU_035527_1_0_5; -.
DR   OrthoDB; 9806359at2; -.
DR   Proteomes; UP000008326; Plasmid pCCS1.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004475; F:mannose-1-phosphate guanylyltransferase (GTP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:InterPro.
DR   CDD; cd02213; cupin_PMI_typeII_C; 1.
DR   CDD; cd02509; GDP-M1P_Guanylyltransferase; 1.
DR   Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR   InterPro; IPR049577; GMPP_N.
DR   InterPro; IPR006375; Man1P_GuaTrfase/Man6P_Isoase.
DR   InterPro; IPR001538; Man6P_isomerase-2_C.
DR   InterPro; IPR005835; NTP_transferase_dom.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR011051; RmlC_Cupin_sf.
DR   NCBIfam; TIGR01479; GMP_PMI; 1.
DR   PANTHER; PTHR46390; MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE; 1.
DR   PANTHER; PTHR46390:SF1; MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE; 1.
DR   Pfam; PF01050; MannoseP_isomer; 1.
DR   Pfam; PF00483; NTP_transferase; 1.
DR   SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR   SUPFAM; SSF51182; RmlC-like cupins; 1.
PE   3: Inferred from homology;
KW   GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW   ECO:0000313|EMBL:ABD57130.1}; Plasmid {ECO:0000313|EMBL:ABD57130.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008326};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ABD57130.1}.
FT   DOMAIN          4..284
FT                   /note="Nucleotidyl transferase"
FT                   /evidence="ECO:0000259|Pfam:PF00483"
FT   DOMAIN          315..465
FT                   /note="Mannose-6-phosphate isomerase type II C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01050"
SQ   SEQUENCE   470 AA;  50761 MW;  E6780F7ED142BFCB CRC64;
     MIHPIILCGG AGTRLWPASR KAYPKQFAPL LGRDSLYQAT LKRFAGPDFA APLIMTAEEF
     RFMATDQAAD IGLGDARVVI EPSPRDTAPA VLSAALLLAA DDPDALMFVA SSDHVIEDVP
     AFLKAIAQGR PSAETGAMVT FGITPDRPET GYGYLELANT PDGALVEVRS FQEKPDAATA
     RTFLEAGTYL WNAGMFLFRA SDVITAFETH APDLLPPCRA AIAGGKADLG FFRLEAEAYG
     GCQAISFDFA VMEKAASVSA VPLDCGWSDL GAWDALWQVS ARDADGVATH GPVTALECRD
     SYLHSDDDAM QLVGLGLDGM VAVAMRDAVL VAPKDRAQDV KAVVATLRAA GVAQADDYPR
     FHRPWGWYET LCMDGRFQVK RIMVKPGGVL SLQSHHHRSE HWIVVAGTAE VTIDDEVKLV
     TENEGVYIPL GAVHRMANPG KLPMYLIEVQ TGAYLGEDDI VRYEDIYDRS
//

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