ID Q29123_PIG Unreviewed; 538 AA.
AC Q29123;
DT 01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT 01-NOV-1996, sequence version 1.
DT 27-MAR-2024, entry version 124.
DE SubName: Full=Vascular cell adhesion molecule {ECO:0000313|EMBL:AAB59281.1};
GN Name=VCAM {ECO:0000313|EMBL:AAB59281.1};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|EMBL:AAB59281.1};
RN [1] {ECO:0000313|EMBL:AAB59281.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=TNF-stimulated aortic {ECO:0000313|EMBL:AAB59281.1};
RX PubMed=7516159; DOI=10.1006/bbrc.1994.1772;
RA Tsang Y.T.M., Haskard D.O., Robinson M.K.;
RT "Cloning and expression kinetics of porcine vascular cell adhesion
RT molecule.";
RL Biochem. Biophys. Res. Commun. 201:805-812(1994).
RN [2] {ECO:0000313|EMBL:AAB59281.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=TNF-stimulated aortic {ECO:0000313|EMBL:AAB59281.1};
RX PubMed=8525525;
RA Mueller J.P., Evans M.J., Cofiell R., Rother R.P., Matis L.A.,
RA Elliott E.A.;
RT "Porcine vascular cell adhesion molecule (VCAM) mediates endothelial cell
RT adhesion to human T cells. Development of blocking antibodies specific for
RT porcine VCAM.";
RL Transplantation 60:1299-1306(1995).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
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DR EMBL; L43124; AAB59281.1; -; mRNA.
DR AlphaFoldDB; Q29123; -.
DR ABCD; Q29123; 2 sequenced antibodies.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005178; F:integrin binding; IEA:InterPro.
DR GO; GO:0098609; P:cell-cell adhesion; IEA:InterPro.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR InterPro; IPR047012; ICAM_VCAM.
DR InterPro; IPR003987; ICAM_VCAM_N.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR008424; Ig_C2-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013151; Immunoglobulin.
DR InterPro; IPR003989; VCAM-1.
DR PANTHER; PTHR13771; INTERCELLULAR ADHESION MOLECULE; 1.
DR PANTHER; PTHR13771:SF14; VASCULAR CELL ADHESION PROTEIN 1; 1.
DR Pfam; PF05790; C2-set; 1.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF13927; Ig_3; 3.
DR PRINTS; PR01472; ICAMVCAM1.
DR PRINTS; PR01474; VCAM1.
DR SMART; SM00409; IG; 4.
DR SMART; SM00408; IGc2; 4.
DR SUPFAM; SSF48726; Immunoglobulin; 5.
DR PROSITE; PS50835; IG_LIKE; 4.
PE 2: Evidence at transcript level;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|SAM:Phobius}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..538
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004204215"
FT TRANSMEM 499..519
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 25..112
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 224..305
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 310..394
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 399..483
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 538 AA; 58713 MW; 8A7CD36D0A2F0717 CRC64;
MPRNIVVIFG ASNILWMVFA VSQNVKVEIV PEDKMIAQIG DSASLTCSAP DCESSLSFSW
RTQIDSPLNG KVKTNGTRST LVMNPVSFEN EHSYLCTVSC GNLKGERGIQ VEIYSFPKDP
EIHWSSLPEV GKPVTVRCLV PDVYPVEKLE IELLKDNHSM VSQNFLELID IKSKETKSLE
FTFTPTEEDI GKAIVCQATL IIDGQPSVKT TPEKMQVYIS PKDPVISVNP STSLQEGDSV
MMTCTSEGLP APQISWSKKL DNGDQQLLSG NATLTLIAMR MEDSGIYVCE GVNPVGTNRK
EVELTVQVAP RDTTISVNPS STLEEGSSVN MTCSSDGFPA PKILWSKKLR DGNLEPLSEN
TTLTLTSTKM EDSGIYVCDG INQAGINRKE VELIIQAAPK DLQLIAFPSE SVKEGDTVII
SCTCGNVPPT LIILKKKAET GDTVLKSTDG AYTIHRARLA DAGVYECESK NEIGLQLRSI
TLDVKGRESN KDYFSSELLV LYCASSLIIP AIGVIIYFAR KANMRGSYSL VDAQKSKV
//
