ID Q29JU0_DROPS Unreviewed; 506 AA.
AC Q29JU0; A0A6I8UI20;
DT 04-APR-2006, integrated into UniProtKB/TrEMBL.
DT 04-APR-2006, sequence version 1.
DT 27-MAR-2024, entry version 105.
DE SubName: Full=Catalase {ECO:0000313|RefSeq:XP_001355812.1};
GN Name=LOC4816148 {ECO:0000313|RefSeq:XP_001355812.1};
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245 {ECO:0000313|Proteomes:UP000001819, ECO:0000313|RefSeq:XP_001355812.1};
RN [1] {ECO:0000313|RefSeq:XP_001355812.1}
RP IDENTIFICATION.
RC STRAIN=MV2-25 {ECO:0000313|RefSeq:XP_001355812.1};
RC TISSUE=Whole body {ECO:0000313|RefSeq:XP_001355812.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413;
CC Evidence={ECO:0000256|ARBA:ARBA00001971,
CC ECO:0000256|PIRSR:PIRSR038928-2};
CC -!- SIMILARITY: Belongs to the catalase family.
CC {ECO:0000256|ARBA:ARBA00005329}.
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DR RefSeq; XP_001355812.1; XM_001355776.4.
DR AlphaFoldDB; Q29JU0; -.
DR STRING; 46245.Q29JU0; -.
DR EnsemblMetazoa; FBtr0287227; FBpp0285665; FBgn0081678.
DR GeneID; 4816148; -.
DR KEGG; dpo:4816148; -.
DR eggNOG; KOG0047; Eukaryota.
DR HOGENOM; CLU_010645_2_0_1; -.
DR InParanoid; Q29JU0; -.
DR OMA; FYNQGAR; -.
DR Proteomes; UP000001819; Chromosome 4.
DR Bgee; FBgn0081678; Expressed in male reproductive system and 1 other cell type or tissue.
DR ExpressionAtlas; Q29JU0; baseline.
DR GO; GO:0004096; F:catalase activity; IEA:InterPro.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0042744; P:hydrogen peroxide catabolic process; IEA:UniProtKB-KW.
DR GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR Gene3D; 2.40.180.10; Catalase core domain; 1.
DR InterPro; IPR018028; Catalase.
DR InterPro; IPR024711; Catalase_clade1/3.
DR InterPro; IPR011614; Catalase_core.
DR InterPro; IPR002226; Catalase_haem_BS.
DR InterPro; IPR010582; Catalase_immune_responsive.
DR InterPro; IPR020835; Catalase_sf.
DR PANTHER; PTHR11465; CATALASE; 1.
DR PANTHER; PTHR11465:SF9; CATALASE; 1.
DR Pfam; PF00199; Catalase; 1.
DR Pfam; PF06628; Catalase-rel; 1.
DR PIRSF; PIRSF038928; Catalase_clade1-3; 1.
DR PRINTS; PR00067; CATALASE.
DR SMART; SM01060; Catalase; 1.
DR SUPFAM; SSF56634; Heme-dependent catalase-like; 1.
DR PROSITE; PS00437; CATALASE_1; 1.
DR PROSITE; PS51402; CATALASE_3; 1.
PE 3: Inferred from homology;
KW Heme {ECO:0000256|ARBA:ARBA00022617, ECO:0000256|PIRSR:PIRSR038928-2};
KW Hydrogen peroxide {ECO:0000256|ARBA:ARBA00023324};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR038928-2};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR038928-2};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Peroxidase {ECO:0000256|ARBA:ARBA00022559};
KW Reference proteome {ECO:0000313|Proteomes:UP000001819}.
FT DOMAIN 26..411
FT /note="Catalase core"
FT /evidence="ECO:0000259|SMART:SM01060"
FT BINDING 356
FT /ligand="heme"
FT /ligand_id="ChEBI:CHEBI:30413"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000256|PIRSR:PIRSR038928-2"
SQ SEQUENCE 506 AA; 57987 MW; 7CAE51890BCDEE56 CRC64;
MCSRDPASNQ LIDYKTNDSE VQKDCTTASG TPVGVKDAIM TVGPRGPALL QDFVYLDEVM
HFDTERIPER VAYAKGAGAF GYFECTHDIT RFCAGSLFEK VRKRTAIAMR FSVACGENGS
ADTIREQRGF AVKFYTDDGI WDIVGCNMPV YYVRDPSLFP SLIHAQKRNP QTHLRDADMF
WDFMTLRPET LHALLMYFSD RGTPDGYRHM HGYGAHTYRM VNPNGETFYV KFHFKTDQGI
KNMDARRCSE LMAHDPDYAI RDLYNSIKKG NYPSWTMYIQ VMLNEEAKKS RFNPFDVTKV
WPQKEYPLLP VGKLVLDRNP TNYFTEVEQL AFSPAHMIPG IEPSPDKMLQ GRLFAYGDTQ
RHRLGVNYMQ IPVNCPYRVH VKNFQRDGSM TVTDNQDGAP NYFPNSFCGP KESSRALALQ
TCCPISGDVY RFMSGDTEDN FSQVTDFWTY TLDNCGRKRL IRNLSEHLCE ASQFLQERAV
KLFTMVHSDF GRLMTEALNT ARISKF
//
