ID Q29L48_DROPS Unreviewed; 409 AA.
AC Q29L48; A0A6I8UI67;
DT 04-APR-2006, integrated into UniProtKB/TrEMBL.
DT 04-APR-2006, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE RecName: Full=UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase {ECO:0000256|ARBA:ARBA00017659};
DE EC=2.7.8.15 {ECO:0000256|ARBA:ARBA00013225};
DE AltName: Full=GlcNAc-1-P transferase {ECO:0000256|ARBA:ARBA00029567};
DE AltName: Full=N-acetylglucosamine-1-phosphate transferase {ECO:0000256|ARBA:ARBA00033238};
GN Name=LOC4816570 {ECO:0000313|RefSeq:XP_001355917.1};
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245 {ECO:0000313|Proteomes:UP000001819, ECO:0000313|RefSeq:XP_001355917.1};
RN [1] {ECO:0000313|RefSeq:XP_001355917.1}
RP IDENTIFICATION.
RC STRAIN=MV2-25 {ECO:0000313|RefSeq:XP_001355917.1};
RC TISSUE=Whole body {ECO:0000313|RefSeq:XP_001355917.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = N-
CC acetyl-alpha-D-glucosaminyl-diphosphodolichol + UMP;
CC Xref=Rhea:RHEA:13289, Rhea:RHEA-COMP:9517, Rhea:RHEA-COMP:9519,
CC ChEBI:CHEBI:57683, ChEBI:CHEBI:57705, ChEBI:CHEBI:57865,
CC ChEBI:CHEBI:58427; EC=2.7.8.15;
CC Evidence={ECO:0000256|ARBA:ARBA00034004};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- PATHWAY: Protein modification; protein glycosylation.
CC {ECO:0000256|ARBA:ARBA00004922}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 4 family.
CC {ECO:0000256|ARBA:ARBA00009317}.
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DR RefSeq; XP_001355917.1; XM_001355881.4.
DR AlphaFoldDB; Q29L48; -.
DR SMR; Q29L48; -.
DR STRING; 46245.Q29L48; -.
DR EnsemblMetazoa; FBtr0289270; FBpp0287708; FBgn0078787.
DR GeneID; 4816570; -.
DR KEGG; dpo:4816570; -.
DR eggNOG; KOG2788; Eukaryota.
DR HOGENOM; CLU_029942_0_1_1; -.
DR InParanoid; Q29L48; -.
DR OMA; LPHFNAR; -.
DR UniPathway; UPA00378; -.
DR Proteomes; UP000001819; Chromosome 4.
DR Bgee; FBgn0078787; Expressed in insect adult head and 2 other cell types or tissues.
DR ExpressionAtlas; Q29L48; baseline.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016757; F:glycosyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0003975; F:UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006488; P:dolichol-linked oligosaccharide biosynthetic process; IEA:InterPro.
DR CDD; cd06855; GT_GPT_euk; 1.
DR InterPro; IPR000715; Glycosyl_transferase_4.
DR InterPro; IPR033895; GPT.
DR PANTHER; PTHR10571; UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE; 1.
DR PANTHER; PTHR10571:SF0; UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE; 1.
DR Pfam; PF00953; Glycos_transf_4; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000001819};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
SQ SEQUENCE 409 AA; 45869 MW; 36EC1B37CB65FF10 CRC64;
MSGAAIAINA GISVAAYCMA VRMIPRFREM FIKANLFGND LCKKDKPQVP ESFGVLIGCI
FLVSLFIFIP IPFAFDEAAA TDVVTGGKPA TFPHDKFVEL IAALLSICCM IFLGFADDVL
DLRWRHKLLL PTIATLPLLM VYYVNYNSTT VIMPNFARGL VGTSLNIGAL YYVYMGMLAV
FCTNAINILA GINGLEVGQS LIIAGSILLF NLIEFTLGHQ VDSHIFSIFF MLPFLATTLA
LWKFNKYPSQ VFVGDTYCYF AGMTFAVVGI LGHFSKTLLL FFLPQIINFL YSTPQLFHFV
PCPRHRLPKY DTKTDLLHIS TTEFRLEELN SLGRLMVTVL RKLRLISWHK TADGVVRTNN
LTLINFVLVI FGPVHERVVT QMLMALQVLC TLLALVIRYP LANYFYENT
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