ID Q2AB55_XENTR Unreviewed; 332 AA.
AC Q2AB55;
DT 04-APR-2006, integrated into UniProtKB/TrEMBL.
DT 04-APR-2006, sequence version 1.
DT 27-MAR-2024, entry version 100.
DE RecName: Full=Taste receptor type 2 {ECO:0000256|RuleBase:RU004424};
GN Name=t2r30 {ECO:0000313|Ensembl:ENSXETP00000111754,
GN ECO:0000313|RefSeq:NP_001165487.1,
GN ECO:0000313|Xenbase:XB-GENE-29099575};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|EMBL:BAE80412.1};
RN [1] {ECO:0000313|EMBL:BAE80412.1, ECO:0000313|RefSeq:NP_001165487.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=16484289; DOI=10.1093/molbev/msj106;
RG SMBE Tri-National Young Investigators;
RA Go Y.;
RT "Lineage-specific expansions and contractions of the bitter taste receptor
RT gene repertoire in vertebrates.";
RL Mol. Biol. Evol. 23:964-972(2006).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000111754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000111754};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [3] {ECO:0000313|Ensembl:ENSXETP00000111754}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2021) to UniProtKB.
RN [4] {ECO:0000313|RefSeq:NP_001165487.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU004424}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU004424}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000256|ARBA:ARBA00007376, ECO:0000256|RuleBase:RU004423}.
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DR EMBL; AB249798; BAE80412.1; -; Genomic_DNA.
DR RefSeq; NP_001165487.1; NM_001172016.1.
DR Ensembl; ENSXETT00000119557; ENSXETP00000111754; ENSXETG00000047659.
DR GeneID; 100335079; -.
DR KEGG; xtr:100335079; -.
DR CTD; 100335079; -.
DR Xenbase; XB-GENE-29099575; t2r30.
DR eggNOG; ENOG502SKRK; Eukaryota.
DR HOGENOM; CLU_072337_3_0_1; -.
DR OMA; FLEYRIN; -.
DR OrthoDB; 5317739at2759; -.
DR TreeFam; TF335891; -.
DR Reactome; R-XTR-418594; G alpha (i) signalling events.
DR Reactome; R-XTR-420499; Class C/3 (Metabotropic glutamate/pheromone receptors).
DR Reactome; R-XTR-9717207; Sensory perception of sweet, bitter, and umami (glutamate) taste.
DR Proteomes; UP000008143; Chromosome 9.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0033038; F:bitter taste receptor activity; IEA:InterPro.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR007960; TAS2R.
DR PANTHER; PTHR11394; TASTE RECEPTOR TYPE 2; 1.
DR PANTHER; PTHR11394:SF144; TASTE RECEPTOR TYPE 2; 1.
DR Pfam; PF05296; TAS2R; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor {ECO:0000256|RuleBase:RU004424};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU004424};
KW Receptor {ECO:0000256|RuleBase:RU004424, ECO:0000313|EMBL:BAE80412.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606,
KW ECO:0000256|RuleBase:RU004424};
KW Taste {ECO:0000256|ARBA:ARBA00022480, ECO:0000256|RuleBase:RU004424};
KW Transducer {ECO:0000256|RuleBase:RU004424};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU004424};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 31..54
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 66..88
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 100..126
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 146..170
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 200..226
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 255..276
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 282..302
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 43..266
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 332 AA; 37668 MW; 203118DC3B14966E CRC64;
MDGVTNHSWN NYSTDRLADS VVGNDTTISP VLLIVISVVG IVINMFILSV NFHSWIKGQS
LNPSDLLIVT LAFSNLVFSV TAGVWIIYFG FITYGDFKEY LSYSIMVYVL FCNSWLSTCL
CFYYFVKVSN FKPGYLARLK SKINTLVPRL ILGAQVFSIL NSLFYMLTFF KVNNDNSTLL
FLTNKASSTT NNRIDVFYNA FFLLVNCLIP FFIIVVTTSL IIASLYKHTR RMQRNVGEFG
GPSLHIHHRA ARTMISFLII YLSFYVLSLG NSIFLNKHLL NWVNYMLGCA FSPTQSIVLI
MGNSRLRQTC RNILKSCMKI LSRETTISTV GT
//
