ID Q2AB56_XENTR Unreviewed; 290 AA.
AC Q2AB56;
DT 04-APR-2006, integrated into UniProtKB/TrEMBL.
DT 04-APR-2006, sequence version 1.
DT 27-MAR-2024, entry version 89.
DE RecName: Full=Taste receptor type 2 {ECO:0000256|RuleBase:RU004424};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|EMBL:BAE80411.1};
RN [1] {ECO:0000313|EMBL:BAE80411.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=16484289; DOI=10.1093/molbev/msj106;
RG SMBE Tri-National Young Investigators;
RA Go Y.;
RT "Lineage-specific expansions and contractions of the bitter taste receptor
RT gene repertoire in vertebrates.";
RL Mol. Biol. Evol. 23:964-972(2006).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU004424}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU004424}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000256|ARBA:ARBA00007376, ECO:0000256|RuleBase:RU004423}.
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DR EMBL; AB249797; BAE80411.1; -; Genomic_DNA.
DR RefSeq; NP_001165486.1; NM_001172015.1.
DR AlphaFoldDB; Q2AB56; -.
DR GeneID; 100335078; -.
DR CTD; 100335078; -.
DR HOGENOM; CLU_072337_3_1_1; -.
DR TreeFam; TF335891; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0033038; F:bitter taste receptor activity; IEA:InterPro.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR007960; TAS2R.
DR PANTHER; PTHR11394; TASTE RECEPTOR TYPE 2; 1.
DR PANTHER; PTHR11394:SF144; TASTE RECEPTOR TYPE 2; 1.
DR Pfam; PF05296; TAS2R; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor {ECO:0000256|RuleBase:RU004424};
KW Membrane {ECO:0000256|RuleBase:RU004424, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|RuleBase:RU004424, ECO:0000313|EMBL:BAE80411.1};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606,
KW ECO:0000256|RuleBase:RU004424};
KW Taste {ECO:0000256|ARBA:ARBA00022480, ECO:0000256|RuleBase:RU004424};
KW Transducer {ECO:0000256|RuleBase:RU004424};
KW Transmembrane {ECO:0000256|RuleBase:RU004424, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..35
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 47..71
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 83..109
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 130..150
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 170..196
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 228..251
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 257..277
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 290 AA; 33008 MW; 43873B99229BC77D CRC64;
MLSAIQIIKT IILIITGSCG LILNSWIVAV HLSHWKKGVS LGDCDQIILI MGVTNVLLQC
LLTFSGINYN FQLNYYLNKE FMYVTYIVFF FLTSLWNWLT AWLAICYCLR LGNISHEVFV
GLKKRISSGI TQLLLGTVII VGMINIPLFW TTHIKAKQNT TSTFVFEQDI TYLYFITGFC
SCLPTLITSL CMGLSLKSLL KHVHRMKQNH SQSWSGKMKT HARACTTIFL LMVLNLLFVL
MMFISIIGTN IQNLWDIFFW SIKIASPSGQ ALILLFGNSK LRSDLLKTCF
//
