ID Q2CJW5_OCEGH Unreviewed; 1119 AA.
AC Q2CJW5;
DT 04-APR-2006, integrated into UniProtKB/TrEMBL.
DT 04-APR-2006, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN ORFNames=OG2516_11191 {ECO:0000313|EMBL:EAR53024.1};
OS Oceanicola granulosus (strain ATCC BAA-861 / DSM 15982 / KCTC 12143 /
OS HTCC2516).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Oceanicola.
OX NCBI_TaxID=314256 {ECO:0000313|EMBL:EAR53024.1, ECO:0000313|Proteomes:UP000003635};
RN [1] {ECO:0000313|EMBL:EAR53024.1, ECO:0000313|Proteomes:UP000003635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-861 / DSM 15982 / KCTC 12143 / HTCC2516
RC {ECO:0000313|Proteomes:UP000003635};
RX PubMed=20418400; DOI=10.1128/JB.00412-10;
RA Thrash J.C., Cho J.C., Vergin K.L., Giovannoni S.J.;
RT "Genome sequences of Oceanicola granulosus HTCC2516(T) and Oceanicola
RT batsensis HTCC2597(TDelta).";
RL J. Bacteriol. 192:3549-3550(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAR53024.1}.
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DR EMBL; AAOT01000001; EAR53024.1; -; Genomic_DNA.
DR RefSeq; WP_007255758.1; NZ_CH724107.1.
DR AlphaFoldDB; Q2CJW5; -.
DR STRING; 314256.OG2516_11191; -.
DR eggNOG; COG1074; Bacteria.
DR HOGENOM; CLU_001114_0_0_5; -.
DR OrthoDB; 9810135at2; -.
DR Proteomes; UP000003635; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.160.800; -; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR014151; DNA_helicase_AddA.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR NCBIfam; TIGR02784; addA_alphas; 1.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000003635}.
FT DOMAIN 4..475
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 492..777
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 880..919
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 25..32
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1119 AA; 122096 MW; 7AA668E51DDE2ADD CRC64;
MRAWNEATRA QVEAADPANS TWLSANAGSG KTRVLTERVA RLLLGGVDPQ NILCLTFTKA
AAAEMQNRLF HRLGSWAMME AGKLREELSE LGAAQPEELD EARRLFARAI ETPGGLKIQT
IHAFCAGVLR RFPLEAGISP RFTEMEDRAA ALLRAEILDE LAEADPAAVD GIARLYTGAD
IADLTGEITA NRAAFLDPPN DDTLAAGFGA ATGLTAAGIV RSHLGADVIT LLGEVHRVCL
GGGKNDTKAA DKLAPLLGKR EMDIPAFHVL CDVFLTGGKA KAPYSAKLTG FPTKAVRGSC
AELMGRLDPV MQTVEDIRPA VIAQLAYERT RALYAFATPF CRAFETKKLS RGLLDFDDLI
LKTRALLEDR ALAQWVLFRL DGGIDHILVD EAQDTSPDQW RVIERLTDEL AAGRGAGEDR
ERTLFVVGDK KQSIYSFQGA DAEMFEAKRE LFTDRLATGG GKLHSQPLQF SFRSAAAILQ
LVDATFQGDL REGLDPVVYH RTFKTELPGR VDLWPVEPEA EKTDTDAPWY KPVDHVSEQH
HDVKLARRVA EQIQTLINRK ATIPVEKGGR ILRRPIHEGD ILILVQRRST LFAEIIRACK
KLGLRIAGAD RLRVGAELAV RDLAALLRFL ALPEDDLSLA AALRSPLFGW TEQELFTLAH
HRRGLLWSAL RDSDDHPETL KTLRDLRAQT DFLRPYDLLS RILIRHGGRQ KLLDRLGAEA
EDGIDALLAQ ALAYERSTVP SLTGFLSWME TEDVEVKRQM DEQGERIRVM TIHGAKGLEA
PVVILPETGV RQTQSDTRSA IWPLEDVVAW RPSTDRLPAA LQDARAKLVE AEERERRRLL
YVALTRAEKW LIVCGAGKIG KEVGDSWYGM VEAGLERLGA LPHPQPGGDG LRYETGDWSA
PDLAPPEPDA AEPVAPPNFA PVALPPAALQ TLSPSDLGGA KVLPGDPAGG DREAALERGN
QVHLLLEHLP GTLPLERANV ALSLFPDLPA PERQSLLTDA EAVLSAPGLA ELFEKGLAEV
PVTATLAELN GARLHGTIDL LIPGEPLRVI DFKTNRLVPK TPEEVPEGLL RQMGAYAAAL
GQIYPGRAIE TAILWTSTAE LMPLPHSLVI AALLRAGAP
//
