ID Q2FRC2_METHJ Unreviewed; 612 AA.
AC Q2FRC2;
DT 21-MAR-2006, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2006, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN OrderedLocusNames=Mhun_1895 {ECO:0000313|EMBL:ABD41610.1};
OS Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 /
OS JF-1).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanomicrobiales; Methanospirillaceae; Methanospirillum.
OX NCBI_TaxID=323259 {ECO:0000313|EMBL:ABD41610.1, ECO:0000313|Proteomes:UP000001941};
RN [1] {ECO:0000313|Proteomes:UP000001941}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 27890 / DSM 864 / NBRC 100397 / JF-1
RC {ECO:0000313|Proteomes:UP000001941};
RX PubMed=26744606; DOI=10.1186/s40793-015-0124-8;
RA Gunsalus R.P., Cook L.E., Crable B., Rohlin L., McDonald E., Mouttaki H.,
RA Sieber J.R., Poweleit N., Zhou H., Lapidus A.L., Daligault H.E., Land M.,
RA Gilna P., Ivanova N., Kyrpides N., Culley D.E., McInerney M.J.;
RT "Complete genome sequence of Methanospirillum hungatei type strain JF1.";
RL Stand. Genomic Sci. 11:2-2(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00006594}.
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DR EMBL; CP000254; ABD41610.1; -; Genomic_DNA.
DR RefSeq; WP_011448874.1; NC_007796.1.
DR AlphaFoldDB; Q2FRC2; -.
DR STRING; 323259.Mhun_1895; -.
DR REBASE; 17793; MhuORF1895P.
DR EnsemblBacteria; ABD41610; ABD41610; Mhun_1895.
DR GeneID; 3923427; -.
DR KEGG; mhu:Mhun_1895; -.
DR eggNOG; arCOG02634; Archaea.
DR HOGENOM; CLU_007510_1_1_2; -.
DR InParanoid; Q2FRC2; -.
DR OrthoDB; 112158at2157; -.
DR Proteomes; UP000001941; Chromosome.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR GO; GO:1901576; P:organic substance biosynthetic process; IEA:UniProt.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR047939; BREX_1_PglX.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR011639; MethylTrfase_TaqI-like_dom.
DR InterPro; IPR046816; MmeI_Mtase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; NF033452; BREX_1_MTaseX; 1.
DR PANTHER; PTHR33841:SF1; ADENINE-SPECIFIC METHYLTRANSFERASE PGLX; 1.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR Pfam; PF07669; Eco57I; 1.
DR Pfam; PF20473; MmeI_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000001941};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 292..366
FT /note="MmeI-like DNA-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF20473"
FT DOMAIN 465..550
FT /note="Type II methyltransferase M.TaqI-like"
FT /evidence="ECO:0000259|Pfam:PF07669"
SQ SEQUENCE 612 AA; 71144 MW; 9733E7BE43B7ADCE CRC64;
MDKAKIQLFS DSLRKNLLEE TKKRAAHYGI TGKAIATVEQ EFEDSIIIGG EVYPRSIRDQ
RAYLVKEIEK KGYDRVMEEV TYTWFNRFVA IRFMEVNDYL PVRVFSSTSS GKTDPDILTK
ALDLTFLDID REHVLDLKSD GRHEELFRYL FLRLCNYLHT TMPFLFEPIQ DYSELLFPDR
LLHTDSMLRD LNTIIPEDDW RETEIIGWIY QDYIAEKKDV LIKAKKQYTA DQIPAVTQLF
TPKWIVQYMV ENSLGRLWML NRPHSRLYER MEYYIRPDEQ ETDFLKISSP EELKVCDPAC
GSGHILVYAF DLLYEIYKEE GYLEQEIPEF ILTHNLYGIE IDKRAGSLAA FALVMKARRM
DKKFFDHPVQ PHICVLENIE LDEEDIDSYI SAVGSNLFPT GLKETLMQFT EAENFGSLIR
PMVGDVTDIR KILAEKNMSS NLLLFDTHQK VLKVLEQTEY LQPRYHVVIA NPPYMGNKGM
NNQLRDYAKK FYPNSKSDLF AMFIERGFDL LVHQGYSAMV TMQSWMFLSS YEKMRQNILD
NATIICMSHM ANGVMGIAFG TAATVWCNAY IKDYKGYFCY VEYENIGSDG KPISFPPYNE
RNKGAGLSIT GA
//