ID Q2GE23_NEOSM Unreviewed; 377 AA.
AC Q2GE23;
DT 21-MAR-2006, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2006, sequence version 1.
DT 27-MAR-2024, entry version 93.
DE SubName: Full=Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family {ECO:0000313|EMBL:ABD45962.1};
GN OrderedLocusNames=NSE_0384 {ECO:0000313|EMBL:ABD45962.1};
OS Neorickettsia sennetsu (strain ATCC VR-367 / Miyayama) (Ehrlichia
OS sennetsu).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rickettsiales;
OC Anaplasmataceae; Neorickettsia.
OX NCBI_TaxID=222891 {ECO:0000313|EMBL:ABD45962.1, ECO:0000313|Proteomes:UP000001942};
RN [1] {ECO:0000313|EMBL:ABD45962.1, ECO:0000313|Proteomes:UP000001942}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC VR-367 / Miyayama {ECO:0000313|Proteomes:UP000001942};
RX PubMed=16482227; DOI=10.1371/journal.pgen.0020021;
RA Dunning Hotopp J.C., Lin M., Madupu R., Crabtree J., Angiuoli S.V.,
RA Eisen J.A., Seshadri R., Ren Q., Wu M., Utterback T.R., Smith S., Lewis M.,
RA Khouri H., Zhang C., Niu H., Lin Q., Ohashi N., Zhi N., Nelson W.,
RA Brinkac L.M., Dodson R.J., Rosovitz M.J., Sundaram J., Daugherty S.C.,
RA Davidsen T., Durkin A.S., Gwinn M., Haft D.H., Selengut J.D.,
RA Sullivan S.A., Zafar N., Zhou L., Benahmed F., Forberger H., Halpin R.,
RA Mulligan S., Robinson J., White O., Rikihisa Y., Tettelin H.;
RT "Comparative genomics of emerging human ehrlichiosis agents.";
RL PLoS Genet. 2:208-222(2006).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- SIMILARITY: Belongs to the UbiH/COQ6 family.
CC {ECO:0000256|ARBA:ARBA00005349}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP000237; ABD45962.1; -; Genomic_DNA.
DR RefSeq; WP_011451779.1; NC_007798.1.
DR AlphaFoldDB; Q2GE23; -.
DR STRING; 222891.NSE_0384; -.
DR KEGG; nse:NSE_0384; -.
DR eggNOG; COG0654; Bacteria.
DR HOGENOM; CLU_009665_8_1_5; -.
DR OrthoDB; 9796623at2; -.
DR UniPathway; UPA00232; -.
DR Proteomes; UP000001942; Chromosome.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR InterPro; IPR002938; FAD-bd.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR010971; UbiH/COQ6.
DR NCBIfam; TIGR01988; Ubi-OHases; 1.
DR PANTHER; PTHR43876; UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43876:SF7; UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL; 1.
DR Pfam; PF01494; FAD_binding_3; 1.
DR PRINTS; PR00420; RNGMNOXGNASE.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW Monooxygenase {ECO:0000256|ARBA:ARBA00023033};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Ubiquinone {ECO:0000313|EMBL:ABD45962.1}.
FT DOMAIN 8..332
FT /note="FAD-binding"
FT /evidence="ECO:0000259|Pfam:PF01494"
SQ SEQUENCE 377 AA; 42484 MW; DC4829674E8E93FF CRC64;
MTKFYDFIIS GGGLSGVLAA HLLKDLGLSC YIFDKSGEVS VDFRTSAISY ESVRFFEKLG
LWQVMEPFAV PINDIYSFQE KSGSFLHFEG AQANLDFSMS YVVPNLVLQD ILYKGIDINY
GCTYKNVCYS HDRVRVDFAD KVIEGRYMLV AEGRYSNTAG LLGFKMIRSS YRQSCLICNL
RSTGREHSNV AVEMFLESGP FALLPLRKST EFSLIWTAKF PFANTLATID EKEFLSEVQK
ISGIEFEKIL TPRVVYPIVL NFCMNPRKGP VMLIGDSAHG IHPVAGQGFN LAVYDLKDLH
DVLNKYGLDN FDELIDAYLK RRKRSALSMV AFTHFLVKSF SCASPSLRVA RGFVLDVIES
SSWLKRFFME RAAGKGL
//
