ID Q2GQZ0_CHAGB Unreviewed; 942 AA.
AC Q2GQZ0;
DT 21-MAR-2006, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2006, sequence version 1.
DT 24-JAN-2024, entry version 81.
DE SubName: Full=DNA mismatch repair protein msh-2 {ECO:0000313|EMBL:EAQ83210.1};
GN ORFNames=CHGG_09614 {ECO:0000313|EMBL:EAQ83210.1};
OS Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS NRRL 1970) (Soil fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX NCBI_TaxID=306901 {ECO:0000313|EMBL:EAQ83210.1, ECO:0000313|Proteomes:UP000001056};
RN [1] {ECO:0000313|Proteomes:UP000001056}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970
RC {ECO:0000313|Proteomes:UP000001056};
RX PubMed=25720678; DOI=10.1128/genomeA.00021-15;
RA Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL Genome Announc. 3:E0002115-E0002115(2015).
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|RuleBase:RU003756}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|RuleBase:RU003756}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CH408035; EAQ83210.1; -; Genomic_DNA.
DR RefSeq; XP_001227541.1; XM_001227540.1.
DR AlphaFoldDB; Q2GQZ0; -.
DR STRING; 306901.Q2GQZ0; -.
DR GeneID; 4396749; -.
DR VEuPathDB; FungiDB:CHGG_09614; -.
DR eggNOG; KOG0219; Eukaryota.
DR HOGENOM; CLU_002472_10_0_1; -.
DR InParanoid; Q2GQZ0; -.
DR OMA; LVRFPQK; -.
DR OrthoDB; 168255at2759; -.
DR Proteomes; UP000001056; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd03285; ABC_MSH2_euk; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR011184; DNA_mismatch_repair_Msh2.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR032642; Msh2_ATP-bd.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF35; DNA MISMATCH REPAIR PROTEIN MSH2; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF005813; MSH2; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU003756};
KW DNA repair {ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003756};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003756}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001056}.
FT DOMAIN 733..749
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 861..883
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 942 AA; 105177 MW; 8EFB4446BA531ED8 CRC64;
MSSRPELKVD DEHGFIRFFK SLPTVDDDVI RIFDRGDWYT AHGENANFIA RTVYKTTSVV
RQLGRNDSTG LQSVTMTMTV FRQFLREALY KLGKRIEIWA SPNGRMNWKI AKQASPGNLQ
DVEEDLGSLA EAAPVILAVK ISAKASEARA VGVCFADASV RELGVSEFLD NDSYSNFEAL
LIQLGVKECL IHMEKADKEK DPELAKVKQI IDNCGVAISE RPVADFGIKD IEQDLARLLK
DERSATLLPQ TDLKLAMGSA AALIQYLGVL HDPSNFGQYQ LYQHDLAQFM KLDAAALKAL
NLMPGARDGS KTMSLFGLLN HCKTPVGSRL LAQWLKQPLM DKNEIEKRQQ LVEAFANDTE
LRQTMQEEHL RSIPDLYRLA KRFQRKKANL EDVVRAYQAV IRLPGFLGTL EGVMDETYRD
PLDEAYTNKL RELSDSLVKL QEMVETTVDL DALDNHEFII KPEFDDSLRI IRKRLDRLRS
EMDREFADAA SDLGQERDKK IFLENHKVHG WCMRLTRTEA GCIRQKSRYQ ECSTQKNGVY
FTTKTLQGYR REFDQLSQNY NRTQSGLVNE VVGVASSYSP VLEKLGGVLA HLDVIVSLAH
CSVHAPISYV RPTIHPRGEG QTVLVEARHP CLEMQDDVQF ITNDVELTRD KSSFLIITGP
NMGGKSTYIR QIGVIALMAQ IGCFVPCSSA ELTIFDSILA RVGASDSQLK GVSTFMAEML
ETANILKSAT AESLIIIDEL GRGTSTYDGF GLAWAISEHI VKEIGCSALF ATHFHELTAL
ADQYPQVRNL HVTAHISGSS SAATAEKKKQ KAEDEKREVT LLYKVEPGVC DQSFGIHVAE
LVRFPDKVVR MAKRKADELE DFTSAKQDGD STPAAAAAAS PEYSKRDVEE GSALLKEVLV
RWKDEVRAGT MSKAEMVARL KEMVGKDGKL LANPFFQSVK AL
//
