ID   Q2GV26_CHAGB            Unreviewed;       863 AA.
AC   Q2GV26;
DT   21-MAR-2006, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2006, sequence version 1.
DT   27-MAR-2024, entry version 54.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=CHGG_08178 {ECO:0000313|EMBL:EAQ86925.1};
OS   Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS   NRRL 1970) (Soil fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX   NCBI_TaxID=306901 {ECO:0000313|EMBL:EAQ86925.1, ECO:0000313|Proteomes:UP000001056};
RN   [1] {ECO:0000313|Proteomes:UP000001056}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970
RC   {ECO:0000313|Proteomes:UP000001056};
RX   PubMed=25720678; DOI=10.1128/genomeA.00021-15;
RA   Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT   "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL   Genome Announc. 3:E0002115-E0002115(2015).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC       multimeric enzyme that catalyzes the translocation of protons across
CC       the membranes. Required for assembly and activity of the V-ATPase.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; CH408033; EAQ86925.1; -; Genomic_DNA.
DR   RefSeq; XP_001225834.1; XM_001225833.1.
DR   AlphaFoldDB; Q2GV26; -.
DR   STRING; 306901.Q2GV26; -.
DR   GeneID; 4393403; -.
DR   VEuPathDB; FungiDB:CHGG_08178; -.
DR   eggNOG; KOG2189; Eukaryota.
DR   HOGENOM; CLU_005230_0_2_1; -.
DR   InParanoid; Q2GV26; -.
DR   OMA; FYLWFFL; -.
DR   OrthoDB; 1967517at2759; -.
DR   Proteomes; UP000001056; Unassembled WGS sequence.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629:SF63; V-TYPE PROTON ATPASE SUBUNIT A; 1.
DR   PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW   ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001056};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM        422..447
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        467..487
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        548..566
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        586..605
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        642..665
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        762..782
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        794..814
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   COILED          101..128
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   863 AA;  98027 MW;  58C833BD1B1E36A8 CRC64;
     MAPARDTPFR SADMSMVQLY ISNEIGREVV NALGELGLVQ FRDLNGEMSA FQRAFTQDIR
     RLDNVERQLR YFHAQMDKAG IALRKLDLDV DTLAPPTTTE IDELAERSQS LEQRVSSLNE
     SYETLKKREV ELTEWRWVLR EAGGFFDRAH GNVEEIRAST DNDDAPLLQD VEHHLSAPEV
     ERSFSGMNIG FVAGVIARDR VAAFERILWR TLRGNLYMNQ AEIPDPLVDP TTNEPVQKNV
     FVIFAHGKEI LAKIRKISES MGAEVYNVDE NSDLRRDQVH EVNARLNDVQ SVLRNTQQTL
     EAELTQISRS LSAWMILVGK EKAVYNSLNN FSYDRARRTL IAEGWCPTHD LPLIRSTLQD
     VTNRAGLSVP SIINEIRTNK KPPTYLKTNK FTEAFQTIVN AYGTATYQEV NPAIPVIVTF
     PFLFAVMFGD LGHAIIMLCA SLAMIYWEKP LKKVTFELFA MVYYGRYIAL VMAVFSIYTG
     LIYNDIFSKS MTLFKSSWEW DVPEGFTTGQ TVTARIRDPN YRYPFGLDWR WHGTENDLLF
     SNSYKMKMSI ILGWAHMTYS LCFAYINARH FKRPVDIWGN FLPGMIFFQA IFGYLVICII
     YKWTVDWFAI GQQPPGLLNM LIYMFLQPGF IDVPLYRGQK YVQVGLLLLA LVQVPILLFL
     KPFYLRWEHN RARAKGYRGI GERSRVSALD EDDDAGANGR HSVDSAGEGA AMIAQDLDGD
     DDDGHGGHGG EFDFGEVMIH QVIHTIEFCL NCVSHTASYL RLWALSLAHQ QLSAVLWSMT
     MGPPLAGSGI GGPIFLVIVF AAFFFLSCII LIIMEGVSAM LHSLRLAWVE SFSKFAEFGG
     WPFAPFSFKQ LLEESEELKE YMG
//