ID   Q2GVJ1_CHAGB            Unreviewed;      1173 AA.
AC   Q2GVJ1;
DT   21-MAR-2006, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2006, sequence version 1.
DT   27-MAR-2024, entry version 69.
DE   RecName: Full=Reverse transcriptase domain-containing protein {ECO:0000259|PROSITE:PS50878};
GN   ORFNames=CHGG_08013 {ECO:0000313|EMBL:EAQ86760.1};
OS   Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS   NRRL 1970) (Soil fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX   NCBI_TaxID=306901 {ECO:0000313|EMBL:EAQ86760.1, ECO:0000313|Proteomes:UP000001056};
RN   [1] {ECO:0000313|Proteomes:UP000001056}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970
RC   {ECO:0000313|Proteomes:UP000001056};
RX   PubMed=25720678; DOI=10.1128/genomeA.00021-15;
RA   Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT   "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL   Genome Announc. 3:E0002115-E0002115(2015).
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DR   EMBL; CH408033; EAQ86760.1; -; Genomic_DNA.
DR   RefSeq; XP_001225669.1; XM_001225668.1.
DR   AlphaFoldDB; Q2GVJ1; -.
DR   GeneID; 4393950; -.
DR   VEuPathDB; FungiDB:CHGG_08013; -.
DR   eggNOG; KOG1075; Eukaryota.
DR   HOGENOM; CLU_000680_23_6_1; -.
DR   InParanoid; Q2GVJ1; -.
DR   OMA; THPLWEN; -.
DR   OrthoDB; 2467009at2759; -.
DR   Proteomes; UP000001056; Unassembled WGS sequence.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   CDD; cd01650; RT_nLTR_like; 1.
DR   Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR   InterPro; IPR000477; RT_dom.
DR   PANTHER; PTHR33481; REVERSE TRANSCRIPTASE; 1.
DR   PANTHER; PTHR33481:SF1; REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF03372; Exo_endo_phos; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF56219; DNase I-like; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   4: Predicted;
KW   Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001056}.
FT   DOMAIN          907..1173
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   REGION          1..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          800..819
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1173 AA;  129947 MW;  E951DFA911934D86 CRC64;
     MWAGQPPSAP SEGPPIEGPL VEVLSQGPLH GPPQRLTPPR LPKAEHFRGL LNGLVNLVPI
     ENRGEARGLA KDLSDLFASQ KQGHHHSKES LGGLTAAHLQ KVVTEAVQAA VGPNRSATQG
     RSWAAVAAGP GQGLQAQPTK IIPQRADREL LVRGANVSAD LAQRSPVEII QAINQASTKQ
     GAIAARKLPS GDTVVTFNDS NTKSWHSNNT QWIQQAFGEQ AKEAGRTYAV LVKGLRKADL
     QGTTEEVFGG ELGLWSVDKV KFRVPTNPGF TRATVLVALR DQEEARKACD QGIIWNAQLL
     DCEPYWAMLE PKQCVGNGAT YRGFAGKRPC VGGVVRGPMG RAGGPGEALC PTQQGQVPCK
     CPCCGGRHPG WAKECPGRAR AKQEAREAYQ YRPRVFEPAR TAAAEPITAP RSAFTYEKAR
     PQEEEVLLWN TEGNKQALEA LLEEAQYDLM AIQEPWINQQ TKSTYCPRGS KYHLVHKASG
     RAAIFVSRKF DTGQWEYETS EEHCKVWFPG LGNSGLELWS IYNPLEDKTL LQTLLSRPAP
     AYPVVLAGDF NLHHPQWDRF GRYERKAEAL LELALQWDLD LRTPAGTITR APQGAQRGRT
     STIDHFWASV GLQTTYYGLE YRGKSDHYPQ ILEADIGGPL PQQTQPGGWN WKMMDRRRVE
     AEAALLPEKI GLEDPGPQGL RAQVREQEGL KEAFNWLVEE LQRIAEVATP RKKANRGHGS
     PWWSVEVQEA QGEARRAERE CKAAPSEHNK ERLNQGLRAL AATINKEKTK TWRTTMQKAT
     HKTDLLWSLE RWARCRSFAP PDPPKLPALT GPPGGQDLST HKEKAEALAR RFYPNPEADL
     SDIEDPDLLE QWVPKFNIEE KVTVGDVRAV LSKISPWKAP GEDHLPIGLL KACGRPLFRV
     LAVLTEACFR IGWFPEIFKR AKTVVLQKPG KEPSTYRTPG GYRPIALLPT VGKVIEALVA
     ERITSAAEAY GLLPAEQMGN REHRSTEVAI RLVVAQVQEA WRQKATASLL QLDISGAFDT
     VNHTRLLATL RLQGYPQWVV LWVKAWLSNR VAILHFDGQK TEDIPVIAGV PQGSPLSPIL
     FILYIASLYQ ALKTTHPLWE NPVALAHPGA SGYSTVKPVE SARFLGVWLD WKLSWRAHQQ
     AVERKLKTQD FALSRIAAKT WGPSLSRASW RST
//