ID Q2H1B8_CHAGB Unreviewed; 514 AA.
AC Q2H1B8;
DT 21-MAR-2006, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2006, sequence version 1.
DT 27-MAR-2024, entry version 90.
DE RecName: Full=Cytochrome P450 {ECO:0008006|Google:ProtNLM};
GN ORFNames=CHGG_04428 {ECO:0000313|EMBL:EAQ87809.1};
OS Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS NRRL 1970) (Soil fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX NCBI_TaxID=306901 {ECO:0000313|EMBL:EAQ87809.1, ECO:0000313|Proteomes:UP000001056};
RN [1] {ECO:0000313|Proteomes:UP000001056}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970
RC {ECO:0000313|Proteomes:UP000001056};
RX PubMed=25720678; DOI=10.1128/genomeA.00021-15;
RA Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL Genome Announc. 3:E0002115-E0002115(2015).
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413;
CC Evidence={ECO:0000256|ARBA:ARBA00001971,
CC ECO:0000256|PIRSR:PIRSR602403-1};
CC -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC {ECO:0000256|ARBA:ARBA00010617, ECO:0000256|RuleBase:RU000461}.
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DR EMBL; CH408032; EAQ87809.1; -; Genomic_DNA.
DR RefSeq; XP_001223642.1; XM_001223641.1.
DR AlphaFoldDB; Q2H1B8; -.
DR STRING; 306901.Q2H1B8; -.
DR GeneID; 4392555; -.
DR VEuPathDB; FungiDB:CHGG_04428; -.
DR eggNOG; KOG0156; Eukaryota.
DR HOGENOM; CLU_022195_0_3_1; -.
DR InParanoid; Q2H1B8; -.
DR OMA; FPVVNDY; -.
DR OrthoDB; 1351063at2759; -.
DR Proteomes; UP000001056; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR CDD; cd11041; CYP503A1-like; 1.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR002403; Cyt_P450_E_grp-IV.
DR InterPro; IPR036396; Cyt_P450_sf.
DR PANTHER; PTHR46206; CYTOCHROME P450; 1.
DR PANTHER; PTHR46206:SF3; P450, PUTATIVE (EUROFUNG)-RELATED; 1.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00465; EP450IV.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
DR PROSITE; PS00086; CYTOCHROME_P450; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Heme {ECO:0000256|ARBA:ARBA00022617, ECO:0000256|PIRSR:PIRSR602403-1};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR602403-1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR602403-1};
KW Monooxygenase {ECO:0000256|ARBA:ARBA00023033,
KW ECO:0000256|RuleBase:RU000461};
KW Oxidoreductase {ECO:0000256|RuleBase:RU000461};
KW Reference proteome {ECO:0000313|Proteomes:UP000001056};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT BINDING 452
FT /ligand="heme"
FT /ligand_id="ChEBI:CHEBI:30413"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000256|PIRSR:PIRSR602403-1"
SQ SEQUENCE 514 AA; 56978 MW; 533C16B75A284F42 CRC64;
MLTEFLLSVR TWTAVAILAS VYYLLFRPRQ PPAFPIVNQY PNDFFRRKAY REVRENAKQL
IIDGLAKHGG PITILIPHGQ KIILPSSLTT WVKSNKDLDH KQLVREDFFS GIPGFEALSL
LHDPDSMLIN LITTKMGPSN NPTLIKAMHT SLSHGLPTLW NNNNSADDDN NTSTSPSSSW
HVLPNWQTAT LGVIARAASS VFAGPEKAAD AEWLALVQGY VGAYFAGVAD LHRYPRWMRP
VAHWFLPNAA ACRRYVARAR AVMDAVLRER AAVREGRGGG EYEDALEWAQ EASGGRVPAG
DVQLSLAMAA LFTTTELFRA LVVEIARRPE LVGELRSEVE EQIGEHGISA AALSGMVLMD
SFMKETQRLN SGPVVLERVA LKDTTLPDGK VIPHGAHIMV DSTDLWNPAV YPNPDQFDAR
RFLRKRQEGD KASQFVQSSP TYNVFGGGRH ICPGRFLASN ELKLALAHIL LKYDVRLAEG
CEPKNFQHGF YVIGDPSVRL EVRRRDAPSG SLLL
//
