ID   Q2H1S5_CHAGB            Unreviewed;       931 AA.
AC   Q2H1S5;
DT   21-MAR-2006, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2006, sequence version 1.
DT   27-MAR-2024, entry version 85.
DE   RecName: Full=Reverse transcriptase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=CHGG_04271 {ECO:0000313|EMBL:EAQ87652.1};
OS   Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS   NRRL 1970) (Soil fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX   NCBI_TaxID=306901 {ECO:0000313|EMBL:EAQ87652.1, ECO:0000313|Proteomes:UP000001056};
RN   [1] {ECO:0000313|Proteomes:UP000001056}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970
RC   {ECO:0000313|Proteomes:UP000001056};
RX   PubMed=25720678; DOI=10.1128/genomeA.00021-15;
RA   Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT   "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL   Genome Announc. 3:E0002115-E0002115(2015).
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DR   EMBL; CH408032; EAQ87652.1; -; Genomic_DNA.
DR   RefSeq; XP_001223485.1; XM_001223484.1.
DR   AlphaFoldDB; Q2H1S5; -.
DR   GeneID; 4393000; -.
DR   VEuPathDB; FungiDB:CHGG_04271; -.
DR   eggNOG; KOG0017; Eukaryota.
DR   HOGENOM; CLU_000384_38_1_1; -.
DR   InParanoid; Q2H1S5; -.
DR   OMA; LYSKQVH; -.
DR   OrthoDB; 2734036at2759; -.
DR   Proteomes; UP000001056; Unassembled WGS sequence.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProt.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006338; P:chromatin remodeling; IEA:UniProt.
DR   GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR   CDD; cd00024; CD_CSD; 1.
DR   CDD; cd09274; RNase_HI_RT_Ty3; 1.
DR   CDD; cd01647; RT_LTR; 1.
DR   Gene3D; 1.10.340.70; -; 1.
DR   Gene3D; 2.40.50.40; -; 1.
DR   Gene3D; 3.30.70.270; -; 2.
DR   Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR016197; Chromo-like_dom_sf.
DR   InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR   InterPro; IPR023780; Chromo_domain.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR001584; Integrase_cat-core.
DR   InterPro; IPR041588; Integrase_H2C2.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR000477; RT_dom.
DR   InterPro; IPR041373; RT_RNaseH.
DR   PANTHER; PTHR24559:SF437; RIBONUCLEASE H; 1.
DR   PANTHER; PTHR24559; TRANSPOSON TY3-I GAG-POL POLYPROTEIN; 1.
DR   Pfam; PF00385; Chromo; 1.
DR   Pfam; PF17921; Integrase_H2C2; 1.
DR   Pfam; PF17917; RT_RNaseH; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SMART; SM00298; CHROMO; 1.
DR   SUPFAM; SSF54160; Chromo domain-like; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS50013; CHROMO_2; 1.
DR   PROSITE; PS50994; INTEGRASE; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   4: Predicted;
KW   Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001056};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW   Transposable element {ECO:0000256|ARBA:ARBA00022464}.
FT   DOMAIN          34..213
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   DOMAIN          546..711
FT                   /note="Integrase catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50994"
FT   DOMAIN          847..893
FT                   /note="Chromo"
FT                   /evidence="ECO:0000259|PROSITE:PS50013"
FT   REGION          420..479
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          880..931
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        420..452
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        453..467
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   931 AA;  106525 MW;  D8583F272C7C4AC4 CRC64;
     MTRGGWRRTR RRGGESRCWF GQPGGRGGYL EKNLEIGHIR PSTSPAGYPV LFVPKKDGKL
     RMCVDYRQLN NETVKNRYPL PLISRLRDQL SGAQHFTRLD LPTAYAHIRI KEGDEWKTAF
     RTPNGHYEYL VMPFGLTNAP ATFQAAIDQA IRHCLDKFAV CYLDDILIYS KTLEEHKEHV
     RQVLDALHEH KLSVNKDKSE FHVKKTVFLG YEISPGWVKI EPEKLEAGRT WPTPTNATEV
     RGFIGFANFV RIFIKNFGEI ARPLHELTKK DTTFQWKQEH EQAFQRIRDA ITADPVLMLS
     DPSKPFEVEA DASDFAIGGQ LGQRDKDGKL HPVAFFSKKL EGPRLNYPIH DKELLAIIEA
     FQEWRPYLSG TTHEVQVYTD HKNLRYFTTT KVLNGRQTRW AEFLSEFNFT IHYKKGSENA
     RNAVRSSGNN DWNETSKESS RTTSAMHGKK SQNPRSQDCD LKERDSGTTT RPTLGPATKK
     ELIRKIHESR LGGHMGISKT VAKIKQNYDF PGIKQTTVEV LAECDLCGRS KPGRHKPYGL
     LQPLPVAERP WSSVTMDFIT KLPTSKDSAT GTKYDSILTV VDRLTKWSYF LPYKESWSAE
     QLADVIYRNV TAVHGWPEEW ITDRDTKFAS KFWQALMTKL GTRSKLSTAY HPQTDGQTER
     LNQIVEQYLR LYVNFQQDDW VELLPTAQLA YNTTVTETTK VTPFFANYGY EADLRQGPDV
     SVPRAAVKAD RMSSLHAMLK EELEFVRTRM KKFYDRNRLE GPRPEEGGKV YLISRNLRTK
     RPSRKLDFRK IGPFKIDKKI SENNYALALP SAKELRDTVF HLSLPEPAHK NARLDKGVEA
     EDEEELWDVE EILDSRITNG QVECSVKWLG FGPEGNSWQP ATNFNCPRGV GGFPPEEPGS
     TQKGTPRTDR PRGKGRSRKT RTNSTRTEGG T
//