ID Q2HBU9_CHAGB Unreviewed; 459 AA.
AC Q2HBU9;
DT 21-MAR-2006, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2006, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=Trichodiene oxygenase {ECO:0008006|Google:ProtNLM};
GN ORFNames=CHGG_02305 {ECO:0000313|EMBL:EAQ90370.1};
OS Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS NRRL 1970) (Soil fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX NCBI_TaxID=306901 {ECO:0000313|EMBL:EAQ90370.1, ECO:0000313|Proteomes:UP000001056};
RN [1] {ECO:0000313|Proteomes:UP000001056}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970
RC {ECO:0000313|Proteomes:UP000001056};
RX PubMed=25720678; DOI=10.1128/genomeA.00021-15;
RA Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL Genome Announc. 3:E0002115-E0002115(2015).
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413;
CC Evidence={ECO:0000256|ARBA:ARBA00001971};
CC -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC {ECO:0000256|ARBA:ARBA00010617, ECO:0000256|RuleBase:RU000461}.
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DR EMBL; CH408030; EAQ90370.1; -; Genomic_DNA.
DR RefSeq; XP_001228821.1; XM_001228820.1.
DR AlphaFoldDB; Q2HBU9; -.
DR STRING; 306901.Q2HBU9; -.
DR GeneID; 4388551; -.
DR VEuPathDB; FungiDB:CHGG_02305; -.
DR eggNOG; KOG0157; Eukaryota.
DR HOGENOM; CLU_001570_14_4_1; -.
DR InParanoid; Q2HBU9; -.
DR OMA; YRSDGRW; -.
DR OrthoDB; 3184603at2759; -.
DR Proteomes; UP000001056; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR CDD; cd11062; CYP58-like; 1.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR036396; Cyt_P450_sf.
DR PANTHER; PTHR24305; CYTOCHROME P450; 1.
DR PANTHER; PTHR24305:SF242; CYTOCHROME P450 MONOOXYGENASE ATNE-RELATED; 1.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00463; EP450I.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
DR PROSITE; PS00086; CYTOCHROME_P450; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Heme {ECO:0000256|ARBA:ARBA00022617, ECO:0000256|RuleBase:RU000461};
KW Iron {ECO:0000256|RuleBase:RU000461};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|RuleBase:RU000461};
KW Monooxygenase {ECO:0000256|RuleBase:RU000461};
KW Oxidoreductase {ECO:0000256|RuleBase:RU000461};
KW Reference proteome {ECO:0000313|Proteomes:UP000001056};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 459 AA; 51961 MW; 3CEB4F446FB4A8F4 CRC64;
MEYINSLRSL LGWRNVAGAA ITYYATLAFY RLFLHPLARF PGPKLAAVSR WYEAYYDVIQ
NGQYTKKIAE LHQQYGPIIR ISPFELHVID PAFYDKIYRN DGRWDKYRFM YDAFGAKSST
VFGADHDAHK AHRAAIAPLF SKAKVVSRQD LIRKNVDKLT NRIETLADSG TTFNLGAAAS
AFTRDIANEY ITGKEYKELD LEDWGIGLSI SSQGAGVFWR TTKHVRWFGP TLRSIPIDWV
MKTADEGTQQ FLRYLQQSEA DTKETLAAAN SSDPKDNSQN TVIHEIVRSK LPPSDKTFER
IFEEIATLTG AAFETTANAL RLILFNVYSN PDILRRVRAE IVTAAATSPD PIPLTTLEKL
PYLTAVLMEG MRLSPAIGTR SPRQTDKDLV YGDWRIPAGT PVGMTTLLMH TDEKFYPDPL
RFNPDRWVDP ADRKALEKVY APFSKGTRIC VGMHKLEAR
//
