ID Q2HGS4_CHAGB Unreviewed; 697 AA.
AC Q2HGS4;
DT 21-MAR-2006, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2006, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=AMP-dependent synthetase/ligase domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=CHGG_00580 {ECO:0000313|EMBL:EAQ92345.1};
OS Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS NRRL 1970) (Soil fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX NCBI_TaxID=306901 {ECO:0000313|EMBL:EAQ92345.1, ECO:0000313|Proteomes:UP000001056};
RN [1] {ECO:0000313|Proteomes:UP000001056}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970
RC {ECO:0000313|Proteomes:UP000001056};
RX PubMed=25720678; DOI=10.1128/genomeA.00021-15;
RA Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL Genome Announc. 3:E0002115-E0002115(2015).
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
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DR EMBL; CH408029; EAQ92345.1; -; Genomic_DNA.
DR RefSeq; XP_001219801.1; XM_001219800.1.
DR AlphaFoldDB; Q2HGS4; -.
DR STRING; 306901.Q2HGS4; -.
DR GeneID; 4387208; -.
DR VEuPathDB; FungiDB:CHGG_00580; -.
DR eggNOG; KOG1175; Eukaryota.
DR HOGENOM; CLU_000022_3_5_1; -.
DR InParanoid; Q2HGS4; -.
DR OMA; FIMGRTD; -.
DR OrthoDB; 144557at2759; -.
DR Proteomes; UP000001056; Unassembled WGS sequence.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43347; ACYL-COA SYNTHETASE; 1.
DR PANTHER; PTHR43347:SF3; ACYL-COA SYNTHETASE SHORT-CHAIN FAMILY MEMBER 3, MITOCHONDRIAL; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001056}.
FT DOMAIN 9..67
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 74..483
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 550..634
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 697 AA; 76403 MW; 3F124BC27F66ADC8 CRC64;
MDHPQDLAHH RSLNDPESFW GHQAEQLYWH KKPSSALRRT TKTLTTGDTH GHWEWFPDGE
ISTCYNCVDR HVLAGRGDVP AILYDSPVTN TKQRITYNQL LDEVEVFAAA LREEGVKKGD
VVLVYMPMIP AALIGILAIN RLGAIHAVVF GGFAAGALAQ RIEASRPVAI LTASCGIDGN
KPPIPYRDFI EEAVRISPWK PSKTIIWQLL WRPTRKLEGE RKWQHLVKSA RARNKRAECV
PVKSTDPIYI IYTSGTTGLP KGVLREAGGH AVGLHLTISY LFGIHGPGDV MGCFSDIGWV
VSHSYTLYGP LLTGASTVLY EGKPVGTPDA SAFWRLVEEY KINTMFTAPT ALRAIRKDDP
DNSHFTRIGE RGGLKSLKAL FLAGERSEPA IITMYQGLLK RYAADNADVV DNWWSSESGS
PISGIALVPY AGKCRQTGMK EKQPPLDIKP GSAGKAMPGF DVRVVDDEGR EIKRGKMGNI
VLALPLAPTA FRTLWEDEER FYKGYLKRFD GKWIDTGDAG WIDERGYIHI MARTDDIINV
AAHRLSTGAL EQAITSHPLV TEACVVGIPD ALKGQMPFAF VVTTTSPSEG TGTGTDTQLF
AEIQKLVRSQ VGPIASLGGM IRGKGMIPKT RSGKTLRRVL RELLENGVHG EFDREVAVPS
TVEDVAVVGV AREAVRGYFE GLGKSGRHGA VEGRAKL
//
