ID Q2HI27_CHAGB Unreviewed; 1714 AA.
AC Q2HI27;
DT 21-MAR-2006, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2006, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=Integrase catalytic domain-containing protein {ECO:0000259|PROSITE:PS50994};
GN ORFNames=CHGG_00127 {ECO:0000313|EMBL:EAQ91892.1};
OS Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS NRRL 1970) (Soil fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX NCBI_TaxID=306901 {ECO:0000313|EMBL:EAQ91892.1, ECO:0000313|Proteomes:UP000001056};
RN [1] {ECO:0000313|Proteomes:UP000001056}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970
RC {ECO:0000313|Proteomes:UP000001056};
RX PubMed=25720678; DOI=10.1128/genomeA.00021-15;
RA Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL Genome Announc. 3:E0002115-E0002115(2015).
CC -!- SIMILARITY: Belongs to the aminoglycoside phosphotransferase family.
CC {ECO:0000256|ARBA:ARBA00006219}.
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DR EMBL; CH408029; EAQ91892.1; -; Genomic_DNA.
DR RefSeq; XP_001219348.1; XM_001219347.1.
DR GeneID; 4387950; -.
DR VEuPathDB; FungiDB:CHGG_00127; -.
DR eggNOG; KOG0017; Eukaryota.
DR HOGENOM; CLU_002055_0_0_1; -.
DR InParanoid; Q2HI27; -.
DR OMA; HRMAFTH; -.
DR OrthoDB; 2554338at2759; -.
DR Proteomes; UP000001056; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05120; APH_ChoK_like; 1.
DR Gene3D; 3.30.200.150; -; 1.
DR Gene3D; 3.90.1200.10; -; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR002575; Aminoglycoside_PTrfase.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR21310; AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED; 1.
DR PANTHER; PTHR21310:SF58; APH DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF01636; APH; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001056};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW Transposable element {ECO:0000256|ARBA:ARBA00022464}.
FT DOMAIN 743..920
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 147..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 414..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 988..1065
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..29
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 147..161
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1036..1050
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1714 AA; 193936 MW; 548635EF14209251 CRC64;
MPQTTSSPEE LDPGSSTPGN SQTGGNPLTP PIPQHILSFV DHSTWGDLAA IDEIEEPTPK
QMNSHIYFLM EIFWASTSYA GRKLWGAFKD EFDEWTAQRW DMVPDRTRKH LRAFLSTNGV
IQDLSQLTPT TPTAPATASP VLATIPTQPQ ASQQIPQAIP APRQQNPIPQ TAPKREADWE
TTSETRQDPQ TWPRPSEEPY YAPRGNAKHL ADLAKLYSDD MKYGGGDYDI LDTKMAIFRD
LCNRIQIPRW QASDAFPIML KDRALRYYYD WLCSGPRDFD TMVAKIRGYF ENEEQRHRYL
AAWRDARLIN MQAEHPDKSK SECLELLINR LALIQRAVPA IGQTEDTLRM QLLNACRGVA
EARMALFNPA PTFEGVRNQL QAAIGITTEN PGPQQFNTDA TDSETFWTDR TYRGSGRESR
FGRNQGGPRR GGFSNSKFSR PPTERKCFVC GKPGCWSTTH PIEDRKKSYE SLFYWHEGSE
LEADYEDNPV SQFFQKYDDH DDDTIDNRGK FHSTFFNDSA PADAIQVTTL LANAATHHFL
TKEDPFQEQD PSETYTAEGR YSATTFRGIM PDSGAAQFST AGQPQFQALQ RQLPSATLDT
TRAGEAIVKF GYGTPKASLG TTTVPTPLGT IDFHVMETET PFLLCLRDMD RLGIKFDNLR
NLLQRGDVEV PVTRKWGHPW LQLTQEEALV CSYLTDGELR RLHRRFGHPS VARLYKLLKT
AGHPVEIQAL ELIAKVCHHC QMHSARPARF KFTLHDDCEF NYEVIMDIFY VEGNKPVLHL
VDAATAFNAA RFLPDVSTKY VWEALRLCWI DVYQGPPDYV VTDAGKQFAS TEFRQNAKEM
AITVKEVPIE AHNSIGKVER YHAPVRRAYE ILRKEDPSAS PELSLQMAVK AVNDTAGPNG
LVPTLLVFGA YPRMTHNSAP SPTLQQRAQA IKKATDAVRR LHAERKVWRE KSRRWEGPFT
LIGVHDEDCI VETSRGAQKF RSTVVKPYYE DPAQQDDPAN QKDTAEKPAP EVPDSQPRST
TPPGNAIEEE PILDSIITPH SQSSSLRADG KVTTPGEPFE ESSKQEIESL ITRGVFEFVK
YDEDLHGDAE IFKSRIVNEI KGKTTDKPYE KSRLVVQGFG DAGKEAILTQ SPTIQRASQR
LILAIAPSLQ RQGCLLWLRD ITQAYVQSEK ALQRKILAFL PQQIRHLYPE GTVMRVIKPL
YGLAEAGTYW WTAFSQREND QLKEGVIQRS KDKQFLTTAE PLVFNGGIVT LNKNGSITLR
QKGQAQKLQL IDANAPDAKQ HAAQHQEPTP DDIKTLNRRI QWQMDSQDRG LTFLPLNLET
ARLYVFVDGS FANNRDFTSQ LGFAIILANE DEINDRHEFS ITGNLIHFSS TKSKRVTRSV
LASEVYGMVA GVDMAYALAS TLRQITAHLN LPAIPTIVCT DSYSLYECLV KLGTTKEKRL
MIDIMALRQS YERRELQEDG SHVRRPLGDY EGDIWGHQLP FGLYLKMVRL AARHESLINE
HAALQLVRRH TNLPVPRALD LVSNSTEIYL LTTRIPGHKV GLCLDSMSDQ ATRMLVDELR
GHLAALRDIP MPGDWQYVIA NAAGGPCFDY RIYAAQPGDG TTWVVGPFLS ENDFNQALRC
GAIPEVVHRS GHRMAFTHGD LNMRNVLVDE YGRLSGVVDW ENAGWFPEYW DYTKAFFVTK
YNQRWLRMVE DMFGQFGDFQ RELATETELW NYCF
//
