ID Q2HWX7_CHV16 Unreviewed; 385 AA.
AC Q2HWX7;
DT 21-MAR-2006, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2006, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Envelope glycoprotein I {ECO:0000256|ARBA:ARBA00013983};
GN Name=US7 {ECO:0000313|EMBL:BAE79602.1};
OS Cercopithecine herpesvirus 16 (CeHV-16) (Herpesvirus papio 2).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Orthoherpesviridae; Alphaherpesvirinae; Simplexvirus;
OC Simplexvirus papiinealpha2.
OX NCBI_TaxID=340907 {ECO:0000313|EMBL:BAE79602.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9541; Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OH NCBI_TaxID=90387; Macaca leonina (Northern pig-tailed macaque) (Macaca nemestrina leonina).
OH NCBI_TaxID=9544; Macaca mulatta (Rhesus macaque).
OH NCBI_TaxID=9545; Macaca nemestrina (Pig-tailed macaque).
RN [1] {ECO:0000313|EMBL:BAE79602.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=A951 {ECO:0000313|EMBL:BAE79602.1};
RA Rogers K.M., Ohsawa K., Eberle R.;
RT "Genomic differences of CeHV-16.";
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AHM96261.1, ECO:0000313|Proteomes:UP000164290}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A951 {ECO:0000313|EMBL:AHM96261.1};
RX PubMed=24606686; DOI=10.1016/j.virol.2013.12.038;
RA Black D., Ohsawa K., Tyler S., Maxwell L., Eberle R.;
RT "A single viral gene determines lethal cross-species neurovirulence of
RT baboon herpesvirus HVP2.";
RL Virology 452-453:86-94(2014).
CC -!- FUNCTION: In epithelial cells, the heterodimer gE/gI is required for
CC the cell-to-cell spread of the virus, by sorting nascent virions to
CC cell junctions. Once the virus reaches the cell junctions, virus
CC particles can spread to adjacent cells extremely rapidly through
CC interactions with cellular receptors that accumulate at these
CC junctions. Implicated in basolateral spread in polarized cells. In
CC neuronal cells, gE/gI is essential for the anterograde spread of the
CC infection throughout the host nervous system. Together with US9, the
CC heterodimer gE/gI is involved in the sorting and transport of viral
CC structural components toward axon tips.
CC {ECO:0000256|ARBA:ARBA00025134}.
CC -!- SUBCELLULAR LOCATION: Cell junction {ECO:0000256|ARBA:ARBA00004282}.
CC Host cell junction {ECO:0000256|ARBA:ARBA00004315}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004402}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004381}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004381}.
CC -!- SIMILARITY: Belongs to the alphaherpesvirinae glycoprotein I family.
CC {ECO:0000256|ARBA:ARBA00005825}.
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DR EMBL; KF908242; AHM96261.1; -; Genomic_DNA.
DR EMBL; AB232132; BAE79602.1; -; Genomic_DNA.
DR Proteomes; UP000164290; Genome.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-SubCell.
DR GO; GO:0044156; C:host cell junction; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR002874; Herpes_gI.
DR Pfam; PF01688; Herpes_gI; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Viral envelope protein {ECO:0000313|EMBL:AHM96261.1};
KW Virion {ECO:0000256|ARBA:ARBA00022844}.
FT TRANSMEM 273..295
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 170..263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 331..385
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 331..347
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 385 AA; 40505 MW; 0C3C93A7B58A4978 CRC64;
MGRPLGFLLA WALWAPIAGV VIRGPTISLV SDSLLAAGPV GANGSFLEDL EVPGEFHFLG
PQVPHATYYD GSVELFHYPP GDRCPRVVLV EELTACPRRH AVAFTLCRAT RRTQSPAYAD
LTLDLAHQPL LRARGPADAV VGLYVARVWV EGATNASLFP LGLAAFPAEG PPAEPPRGET
PADERCDPDV PLWAPRLGPA DVFVPATPTP PARATAIPET TPAPASSAPA TPGAVRSEET
DETPPAPTPG GGEAAPAGPT SEASRYELTT TQIVQIAIPA AILACVALGS CACCLGRRCR
RRRPRPARIY RPPSPVAPSI SAVNEAALAR LGDELKRPPE SPRRGKRRPS QTMVPSLTAI
SEETEAAAVP ELSRSPRRPG PADAR
//
