ID Q2I7F9_SV40 Unreviewed; 701 AA.
AC Q2I7F9;
DT 07-MAR-2006, integrated into UniProtKB/TrEMBL.
DT 07-MAR-2006, sequence version 1.
DT 27-MAR-2024, entry version 90.
DE RecName: Full=Large T antigen {ECO:0000256|ARBA:ARBA00018805};
GN Name=large T {ECO:0000313|EMBL:CBL79143.1};
OS Simian virus 40 (SV40).
OC Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes;
OC Sepolyvirales; Polyomaviridae; Betapolyomavirus.
OX NCBI_TaxID=1891767 {ECO:0000313|EMBL:ABB29881.1, ECO:0000313|Proteomes:UP000108890};
OH NCBI_TaxID=9539; Macaca (macaques).
RN [1] {ECO:0000313|EMBL:ABB29881.1, ECO:0000313|Proteomes:UP000108890}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YNQD38 {ECO:0000313|EMBL:ABB29881.1};
RA Yan D., Zhang Y., Zhao S., Li Z., Huang W., Xu W.;
RT "Analysis of the Complete Sequence of a Highly Divergent SV40 Chinese
RT Isolate.";
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CBL79143.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Ri257 {ECO:0000313|EMBL:CBL79143.1};
RA Fagrouch Z., Karremans K., Deuzing I., van Gessel S., Niphuis H.,
RA Bogers W., Verschoor E.J.;
RT "Molecular analysis of a novel SV40 type in rhesus macaques and evidence
RT for double infections with the classical SV40 type.";
RL J. Clin. Microbiol. 49:1280-1286(2011).
RN [3] {ECO:0000313|Proteomes:UP000113092}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21307214; DOI=10.1128/JCM.01005-10;
RA Fagrouch Z., Karremans K., Deuzing I., van Gessel S., Niphuis H.,
RA Bogers W., Verschoor E.J.;
RT "Molecular analysis of a novel simian virus 40 (SV40) type in rhesus
RT macaques and evidence for double infections with the classical SV40 type.";
RL J. Clin. Microbiol. 49:1280-1286(2011).
CC -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000256|ARBA:ARBA00004147}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; DQ218418; ABB29881.1; -; Genomic_DNA.
DR EMBL; FN812745; CBL79143.1; -; Genomic_DNA.
DR Proteomes; UP000108890; Genome.
DR Proteomes; UP000113092; Genome.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0039576; P:disruption by virus of host JAK-STAT cascade via inhibition of JAK1 activity; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0039645; P:perturbation by virus of host G1/S transition checkpoint; IEA:UniProtKB-KW.
DR GO; GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd06257; DnaJ; 1.
DR Gene3D; 3.40.1310.20; -; 1.
DR Gene3D; 1.10.287.110; DnaJ domain; 1.
DR Gene3D; 1.20.1050.70; Large T antigen, SV40, domain 3; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.10.510; Zinc finger, large T-antigen D1 domain; 1.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR014015; Helicase_SF3_DNA-vir.
DR InterPro; IPR036869; J_dom_sf.
DR InterPro; IPR016392; Lg_T_Ag_polyomavir.
DR InterPro; IPR010932; Lg_T_Ag_Polyomavir_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003133; T_Ag_DNA-bd.
DR InterPro; IPR017910; Znf_lg_T-Ag_D1-typ.
DR InterPro; IPR037102; Znf_lg_T-Ag_D1_dom_sf.
DR Pfam; PF06431; Polyoma_lg_T_C; 1.
DR Pfam; PF02217; T_Ag_DNA_bind; 1.
DR PIRSF; PIRSF003368; Large_T_antigen_polyomaV; 1.
DR SMART; SM00271; DnaJ; 1.
DR SUPFAM; SSF46565; Chaperone J-domain; 1.
DR SUPFAM; SSF55464; Origin of replication-binding domain, RBD-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50076; DNAJ_2; 1.
DR PROSITE; PS51206; SF3_HELICASE_1; 1.
DR PROSITE; PS51287; T_AG_OBD; 1.
DR PROSITE; PS51341; ZF_LTAG_D1; 1.
PE 4: Predicted;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00620}; Early protein {ECO:0000256|ARBA:ARBA00022518};
KW G1/S host cell cycle checkpoint dysregulation by virus
KW {ECO:0000256|ARBA:ARBA00023309};
KW Host nucleus {ECO:0000256|ARBA:ARBA00022562};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Inhibition of host innate immune response by virus
KW {ECO:0000256|ARBA:ARBA00022632};
KW Inhibition of host interferon signaling pathway by virus
KW {ECO:0000256|ARBA:ARBA00022830};
KW Inhibition of host JAK1 by virus {ECO:0000256|ARBA:ARBA00023318};
KW Interferon antiviral system evasion {ECO:0000256|ARBA:ARBA00022830};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Modulation of host cell cycle by virus {ECO:0000256|ARBA:ARBA00022504};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Viral immunoevasion {ECO:0000256|ARBA:ARBA00023280};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00671}.
FT DOMAIN 12..75
FT /note="J"
FT /evidence="ECO:0000259|PROSITE:PS50076"
FT DOMAIN 138..253
FT /note="T-ag OBD"
FT /evidence="ECO:0000259|PROSITE:PS51287"
FT DOMAIN 264..356
FT /note="T-ag D1-type"
FT /evidence="ECO:0000259|PROSITE:PS51341"
FT DOMAIN 399..559
FT /note="SF3 helicase"
FT /evidence="ECO:0000259|PROSITE:PS51206"
FT DNA_BIND 138..253
FT /note="T-ag OBD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00620"
FT REGION 109..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 632..679
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 119..133
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 640..655
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 656..679
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 701 AA; 80982 MW; E4EDE019567DDAB6 CRC64;
MDKVLSREES LQLMDLLGLE RSAWGNIPLM RKAYLKKCKE FHPDKGGDEE KMKKMNTLYK
KMEDGVKYAH QPDFGGFWDA TEIPTYGTDE WEQWWNAFNE DLFCSEEMPS SDEEATADSQ
HSTPPKKKRK VEDPKDFPAE LLSFLSHAVF SNRTLACFAI YTTKEKAALL YKKIMEKYSV
TFISRHNSYN HNILFFLTPH RHRVSAINNY AQKLCTFSFL ICKGVNKEYL MYSALTRDPF
SVVEESLPGG LKEHDFNPEE PEETKQVSWK LVTEYAMETK CDDVLLLLGM YLEFQYSYEM
CLKCMKKEQP SHYKHHEKHY ANAAIFADSK NQKSICQQAV DTVLAKKRVD SLQLTRDQML
TDRFNELLDR MDIMFGSAGS ADIEEWMAGV AWLHCLLPKM DTLVYEFLKC MVYNIPKKRY
WLFKGPIDSG KTTLAAALLE LCGGKALNVN LPLDRLNFEL GVAIDQFLVV FEDVKGTGGE
SRDLPSGQGI NNLDNLRDYL DGSVKVNLEK KHLNKRTQIF PPGIVTMNEY HMPKTLQARF
VKQLNFQPKE YLKHCLARSE FLLEKRIIQS GITLLLMLIW YRPVAEFAQS IQSRIVEWKE
RLDKEFSMSI YQKMKFNVGM GTGVLDWLRD SEDDAEEENV QEKQAGNDNL EDSGHETGVD
SQSQRTFQSP ESSQSVYDHN QPYHICKGFT CFKKPPPPPD T
//
