ID Q2KJ55_BOVIN Unreviewed; 640 AA.
AC Q2KJ55;
DT 07-MAR-2006, integrated into UniProtKB/TrEMBL.
DT 07-MAR-2006, sequence version 1.
DT 27-MAR-2024, entry version 136.
DE SubName: Full=Rho GTPase activating protein 25 {ECO:0000313|EMBL:AAI05511.1, ECO:0000313|Ensembl:ENSBTAP00000032931.4};
GN Name=ARHGAP25 {ECO:0000313|EMBL:AAI05511.1,
GN ECO:0000313|Ensembl:ENSBTAP00000032931.4,
GN ECO:0000313|VGNC:VGNC:26083};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|EMBL:AAI05511.1};
RN [1] {ECO:0000313|EMBL:AAI05511.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=L1 Hereford {ECO:0000313|EMBL:AAI05511.1};
RC TISSUE=Ascending colon {ECO:0000313|EMBL:AAI05511.1};
RA Moore S., Alexander L., Brownstein M., Guan L., Lobo S., Meng Y.,
RA Tanaguchi M., Wang Z., Yu J., Prange C., Schreiber K., Shenmen C.,
RA Wagner L., Bala M., Barbazuk S., Barber S., Babakaiff R., Beland J.,
RA Chun E., Del Rio L., Gibson S., Hanson R., Kirkpatrick R., Liu J.,
RA Matsuo C., Mayo M., Santos R.R., Stott J., Tsai M., Wong D., Siddiqui A.,
RA Holt R., Jones S.J., Marra M.A.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000032931.4, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000032931.4,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSBTAP00000032931.4}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000032931.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; BC105510; AAI05511.1; -; mRNA.
DR RefSeq; NP_001039857.1; NM_001046392.1.
DR STRING; 9913.ENSBTAP00000032931; -.
DR PaxDb; 9913-ENSBTAP00000032931; -.
DR Ensembl; ENSBTAT00000033004.5; ENSBTAP00000032931.4; ENSBTAG00000023976.5.
DR GeneID; 534994; -.
DR KEGG; bta:534994; -.
DR CTD; 9938; -.
DR VEuPathDB; HostDB:ENSBTAG00000023976; -.
DR VGNC; VGNC:26083; ARHGAP25.
DR eggNOG; KOG4270; Eukaryota.
DR GeneTree; ENSGT00950000183015; -.
DR HOGENOM; CLU_020795_1_0_1; -.
DR OMA; HRASTYD; -.
DR TreeFam; TF323577; -.
DR Reactome; R-BTA-9013149; RAC1 GTPase cycle.
DR Proteomes; UP000009136; Chromosome 11.
DR Bgee; ENSBTAG00000023976; Expressed in neutrophil and 102 other cell types or tissues.
DR GO; GO:0001891; C:phagocytic cup; IBA:GO_Central.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0007015; P:actin filament organization; IBA:GO_Central.
DR GO; GO:0051058; P:negative regulation of small GTPase mediated signal transduction; IBA:GO_Central.
DR GO; GO:0006911; P:phagocytosis, engulfment; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd13263; PH_RhoGap25-like; 1.
DR CDD; cd04390; RhoGAP_ARHGAP22_24_25; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR15228:SF20; RHO GTPASE-ACTIVATING PROTEIN 25; 1.
DR PANTHER; PTHR15228; SPERMATHECAL PHYSIOLOGY VARIANT; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 2: Evidence at transcript level;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT DOMAIN 46..151
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 160..354
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 356..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 489..543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 391..413
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 415..430
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 489..528
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 640 AA; 72355 MW; 33DDC31615E1E383 CRC64;
MSLKLPRNWD FNLRGEAGKI ARSRSVMTGE QMAAFHPAST PNPLERPIKM GWLKKQRSIV
RNWQQRYFVL RAQQLYYYKD EEDVKPQGCM YLPGSTIKEI ATNPEEAGKF VFEVIPASCD
QSRTGQDSYV LMASSQAEME EWVKFLRRVS GTPSGAVFGQ RLDETVAYEQ KFGPHLVPIL
VEKCAEFILE HGLNEEGIFR LPGQDNLVKQ LRDAFDAGER PSFDRDTDVH TVASLLKLYL
RDLPEPVVPW SQYDGFLLCG QLMNSDEAKA QQELIKQLSI LPRENYSLLS YICRFLHEIQ
LNCGVNKMSV DNLATVIGVN LIRSKVEDPA VIMRGTPQIQ RVMTMMIRDH EVLFPKSKDA
PLSPPAPQND PKKPPVARSS VGWDATEDPP ISRTDSASDS DATSPTGQQP NDGCLEDKAS
RDKPGDWKPQ SRKRTQTLPN RKCFLTSALQ GANSCKTEIF KNEFWSSSSE AKAGDGHRRT
MSQGVPQLFD SQRTSTYDNV PTQPGSPGDK ASTLSPQACD SKRDALASLN SETGPGKKIS
GEEELESLQR MVQELRKEIE TQKQMYEEQI ENLEKENYDV WAKVVRLNEE LENEKKKSAA
LEISLRNVER CREDVEKRNK VLEEEVKEFV KSIKEPKTDA
//
