ID Q2LC58_MOUSE Unreviewed; 324 AA.
AC Q2LC58;
DT 21-FEB-2006, integrated into UniProtKB/TrEMBL.
DT 21-FEB-2006, sequence version 1.
DT 24-JAN-2024, entry version 147.
DE RecName: Full=Polycomb complex protein BMI-1 {ECO:0000256|ARBA:ARBA00039211};
DE AltName: Full=Polycomb group RING finger protein 4 {ECO:0000256|ARBA:ARBA00042731};
GN Name=Bmi1 {ECO:0000313|MGI:MGI:88174};
GN Synonyms=Pcgf4 {ECO:0000313|EMBL:ABC67286.1};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|EMBL:ABC67286.1};
RN [1] {ECO:0000313|EMBL:ABC67286.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=KM {ECO:0000313|EMBL:ABC67286.1};
RC TISSUE=Testis {ECO:0000313|EMBL:ABC67286.1};
RA Zhang S., Li D., Li E., Lu J.;
RL Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ABC67286.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=KM {ECO:0000313|EMBL:ABC67286.1};
RC TISSUE=Testis {ECO:0000313|EMBL:ABC67286.1};
RX PubMed=16683560;
RA Zhang S.Q., Li D.X., Li E.Z., Wang C.Y., Zhang X.M., Lu J.Y.;
RT "Cloning of Bmi1 cDNA from mouse testis and its expression in E. coli
RT BL21.";
RL Zhonghua Nan Ke Xue 12:308-310(2006).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; DQ337175; ABC67286.1; -; mRNA.
DR RefSeq; NP_031578.2; NM_007552.4.
DR RefSeq; XP_006497374.1; XM_006497311.2.
DR RefSeq; XP_006497375.1; XM_006497312.3.
DR AlphaFoldDB; Q2LC58; -.
DR SMR; Q2LC58; -.
DR EPD; Q2LC58; -.
DR MaxQB; Q2LC58; -.
DR DNASU; 12151; -.
DR GeneID; 12151; -.
DR KEGG; mmu:12151; -.
DR AGR; MGI:88174; -.
DR CTD; 648; -.
DR MGI; MGI:88174; Bmi1.
DR VEuPathDB; HostDB:ENSMUSG00000026739; -.
DR HOGENOM; CLU_046427_0_0_1; -.
DR OMA; IYAWRRN; -.
DR OrthoDB; 460116at2759; -.
DR PhylomeDB; Q2LC58; -.
DR BioGRID-ORCS; 12151; 4 hits in 82 CRISPR screens.
DR ExpressionAtlas; Q2LC58; baseline and differential.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR GO; GO:0035102; C:PRC1 complex; IEA:Ensembl.
DR GO; GO:1990841; F:promoter-specific chromatin binding; IEA:Ensembl.
DR GO; GO:0071535; F:RING-like zinc finger domain binding; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:Ensembl.
DR GO; GO:0030097; P:hemopoiesis; IEA:Ensembl.
DR GO; GO:0045814; P:negative regulation of gene expression, epigenetic; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0048146; P:positive regulation of fibroblast proliferation; IEA:Ensembl.
DR CDD; cd17165; RAWUL_PCGF4; 1.
DR CDD; cd16736; RING-HC_PCGF4; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR032443; RAWUL.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR10825:SF21; POLYCOMB COMPLEX PROTEIN BMI-1; 1.
DR PANTHER; PTHR10825; RING FINGER DOMAIN-CONTAINING, POLYCOMB GROUP COMPONENT; 1.
DR Pfam; PF16207; RAWUL; 1.
DR Pfam; PF13923; zf-C3HC4_2; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 18..57
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 232..324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 242..274
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 281..324
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 324 AA; 36708 MW; AD7DECDB6B29DCE5 CRC64;
MHRTTRIKIT ELNPHLMCVL CGGYFIDATT IIECLHSFCK TCIVRYLETS KYCPICDVQV
HKTRPLLNIR SDKTLQDIVY KLVPGLFKNE MKRRRDFYAA HPSADAANGS NEDRGEVADE
EKRIITDDEI ISLSIEFFDQ SRLDRKVNKE KPKEEVNDKR YLRCPAAMTV MHLRKFLRSK
MDIPNTFQID VMYEEEPLKD YYTLMDIAYI YTWRRNGPLP LKYRVRPTCK RMKMSHQRDG
LTNAGELESD SGSDKANSPA GGVPSTSSCL PSPSTPVQSP HPQFPHISST MNGTSNSPSA
NHQSSFASRP RKSSLNGSSA TSSG
//
