ID Q2LZX3_DROPS Unreviewed; 299 AA.
AC Q2LZX3; A0A6I8UDC4;
DT 21-FEB-2006, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 3.
DT 27-MAR-2024, entry version 102.
DE RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012483};
DE EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
GN Name=LOC4813625 {ECO:0000313|RefSeq:XP_001353650.3};
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245 {ECO:0000313|Proteomes:UP000001819, ECO:0000313|RefSeq:XP_001353650.3};
RN [1] {ECO:0000313|RefSeq:XP_001353650.3}
RP IDENTIFICATION.
RC STRAIN=MV2-25 {ECO:0000313|RefSeq:XP_001353650.3};
RC TISSUE=Whole body {ECO:0000313|RefSeq:XP_001353650.3};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Peroxisome
CC membrane {ECO:0000256|ARBA:ARBA00004585}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004585}.
CC -!- SIMILARITY: Belongs to the pex2/pex10/pex12 family.
CC {ECO:0000256|ARBA:ARBA00008704}.
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DR RefSeq; XP_001353650.3; XM_001353614.4.
DR AlphaFoldDB; Q2LZX3; -.
DR SMR; Q2LZX3; -.
DR STRING; 46245.Q2LZX3; -.
DR EnsemblMetazoa; FBtr0374445; FBpp0336036; FBgn0080636.
DR GeneID; 4813625; -.
DR KEGG; dpo:4813625; -.
DR eggNOG; KOG0317; Eukaryota.
DR HOGENOM; CLU_041707_1_0_1; -.
DR InParanoid; Q2LZX3; -.
DR Proteomes; UP000001819; Chromosome X.
DR Bgee; FBgn0080636; Expressed in insect adult head and 2 other cell types or tissues.
DR ExpressionAtlas; Q2LZX3; baseline.
DR GO; GO:0005778; C:peroxisomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0016558; P:protein import into peroxisome matrix; IEA:InterPro.
DR GO; GO:0060255; P:regulation of macromolecule metabolic process; IEA:UniProt.
DR CDD; cd16527; RING-HC_PEX10; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR025654; PEX2/10.
DR InterPro; IPR006845; Pex_N.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR23350; PEROXISOME ASSEMBLY PROTEIN 10; 1.
DR PANTHER; PTHR23350:SF0; PEROXISOME BIOGENESIS FACTOR 10; 1.
DR Pfam; PF04757; Pex2_Pex12; 1.
DR Pfam; PF13920; zf-C3HC4_3; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW Peroxisome biogenesis {ECO:0000256|ARBA:ARBA00022593};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000001819};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022448};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 246..284
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
SQ SEQUENCE 299 AA; 34819 MW; F2587CF9DBE87FF8 CRC64;
MDFRKARARQ PEIVRSVQKD ARYTNELAED FSDVLRLTGP RNWIKFNQMC KLLAELSYHG
FASVNSLQTL GEEYTGIIQV DGNYKQIPSR LMQLLAIVLE FGGDALFIRL LQKLDLYIAN
HEEIRPEAKL QLKKLIHRLK QSPSYIKALH KSLFYLNSSK YQLSKRTTGI NYVLIRHWLQ
PEFSLYGYKI LGVITFLQVT VSLAISSWDA WREHKRQQLE TLKQTGKRFL HRASSVKSSN
HDAPQCILCL EPRINCSLTP CGHIFCWSCI LEWLEERDEC PLCRESLKKS QVIQLQNYA
//
