ID   Q2MDK9_PROSS            Unreviewed;       409 AA.
AC   Q2MDK9;
DT   21-FEB-2006, integrated into UniProtKB/TrEMBL.
DT   21-FEB-2006, sequence version 1.
DT   27-MAR-2024, entry version 39.
DE   RecName: Full=von Willebrand factor {ECO:0000256|ARBA:ARBA00016619};
DE   Flags: Fragment;
GN   Name=vwf {ECO:0000313|EMBL:CAI70464.1};
OS   Prolemur simus (Greater bamboo lemur) (Hapalemur simus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC   Lemuridae; Prolemur.
OX   NCBI_TaxID=1328070 {ECO:0000313|EMBL:CAI70464.1};
RN   [1] {ECO:0000313|EMBL:CAI70464.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=16243759; DOI=10.1080/10635150500234534;
RA   Poux C., Madsen O., Marquard E., Veites D.R., de Jong W.W., Vences M.;
RT   "Asynchronous colonization of Madagascar by the four endemic clades of
RT   primates, tenrecs, carnivores, and rodents as inferred from nuclear
RT   genes.";
RL   Syst. Biol. 54:719-730(2005).
CC   -!- SUBUNIT: Multimeric. Interacts with F8.
CC       {ECO:0000256|ARBA:ARBA00025858}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000256|ARBA:ARBA00004498}.
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DR   EMBL; AJ891092; CAI70464.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q2MDK9; -.
DR   GO; GO:0007596; P:blood coagulation; IEA:UniProtKB-KW.
DR   CDD; cd01450; vWFA_subfamily_ECM; 2.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 2.
DR   InterPro; IPR032361; VWA_N2.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR22588:SF5; COLLAGEN ALPHA-6(VI) CHAIN; 1.
DR   PANTHER; PTHR22588; UNCHARACTERIZED; 1.
DR   Pfam; PF00092; VWA; 2.
DR   Pfam; PF16164; VWA_N2; 1.
DR   PRINTS; PR00453; VWFADOMAIN.
DR   SMART; SM00327; VWA; 2.
DR   SUPFAM; SSF53300; vWA-like; 2.
DR   PROSITE; PS50234; VWFA; 2.
PE   4: Predicted;
KW   Blood coagulation {ECO:0000256|ARBA:ARBA00023084};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Hemostasis {ECO:0000256|ARBA:ARBA00022696};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT   DOMAIN          40..216
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   DOMAIN          256..409
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:CAI70464.1"
FT   NON_TER         409
FT                   /evidence="ECO:0000313|EMBL:CAI70464.1"
SQ   SEQUENCE   409 AA;  45441 MW;  4627550ACC7E2C83 CRC64;
     QEPGGLEVPP TEAPVSPTTP YVEDTPEPPL HDFYCSKLLD LVFLLDGSSK LSEAEFGVLK
     AFVVDMMERL HISQKRVRVA VVEYHDGSHS YIGLTDRKRP SELRRIASQV KYAGSEVAST
     SEVLKFTLFQ IFSKIDRPEA SRIILLLTAS QEPPRMARNL VRYVQGLKKK KVIVIPVGIG
     PHASLKQIRL IEKQAPENKA FVLSSVDELE QWRDEIISYL CDLAPAASPP TKPPAMAKVT
     VSPSPPGPKR NSMVLDVAFV LEGSDKIGEA DFNRSKEFME EVIQRMDVGQ DSIHVAVLQY
     SYMVTVEYPF SEAQSKGDVL QRVREIRYQG GNKTNTGLAL QYLSEHSFSA SQGDREQAPN
     LVYMVTGNPA SDEIRRLPGD IQLVPIGVGP HANVQELERI SWPNAPILI
//