ID Q2MIZ8_MEDTR Unreviewed; 541 AA.
AC Q2MIZ8;
DT 07-FEB-2006, integrated into UniProtKB/TrEMBL.
DT 07-FEB-2006, sequence version 1.
DT 27-MAR-2024, entry version 108.
DE SubName: Full=Cytochrome P450 family protein {ECO:0000313|EMBL:AES73413.1};
DE SubName: Full=Cytochrome P450 monooxygenase CYP711A12 {ECO:0000313|EMBL:ABC59098.1};
DE SubName: Full=Cytochrome p450 family CYP711A member {ECO:0000313|EMBL:AGI65360.1};
DE SubName: Full=Putative unspecific monooxygenase {ECO:0000313|EMBL:RHN70469.1};
DE EC=1.14.14.1 {ECO:0000313|EMBL:RHN70469.1};
GN Name=CYP711A12 {ECO:0000313|EMBL:ABC59098.1};
GN Synonyms=11430637 {ECO:0000313|EnsemblPlants:AES73413};
GN OrderedLocusNames=MTR_3g104560 {ECO:0000313|EMBL:AES73413.1};
GN ORFNames=Medtr3g104560 {ECO:0000313|EMBL:AGI65360.1},
GN MtrunA17_Chr3g0135841 {ECO:0000313|EMBL:RHN70469.1};
OS Medicago truncatula (Barrel medic) (Medicago tribuloides).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Trifolieae; Medicago.
OX NCBI_TaxID=3880 {ECO:0000313|EMBL:ABC59098.1};
RN [1] {ECO:0000313|EMBL:ABC59098.1}
RP NUCLEOTIDE SEQUENCE.
RA Li L.Y., Yu D.Y.;
RL Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ABC59098.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=17273868; DOI=10.1007/s00425-006-0473-z;
RA Li L., Cheng H., Gai J., Yu D.;
RT "Genome-wide identification and characterization of putative cytochrome
RT P450 genes in the model legume Medicago truncatula.";
RL Planta 226:109-123(2007).
RN [3] {ECO:0000313|EMBL:AES73413.1, ECO:0000313|Proteomes:UP000002051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A17 {ECO:0000313|EMBL:AES73413.1}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:AES73413,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=22089132; DOI=10.1038/nature10625;
RA Young N.D., Debelle F., Oldroyd G.E., Geurts R., Cannon S.B., Udvardi M.K.,
RA Benedito V.A., Mayer K.F., Gouzy J., Schoof H., Van de Peer Y., Proost S.,
RA Cook D.R., Meyers B.C., Spannagl M., Cheung F., De Mita S.,
RA Krishnakumar V., Gundlach H., Zhou S., Mudge J., Bharti A.K., Murray J.D.,
RA Naoumkina M.A., Rosen B., Silverstein K.A., Tang H., Rombauts S.,
RA Zhao P.X., Zhou P., Barbe V., Bardou P., Bechner M., Bellec A., Berger A.,
RA Berges H., Bidwell S., Bisseling T., Choisne N., Couloux A., Denny R.,
RA Deshpande S., Dai X., Doyle J.J., Dudez A.M., Farmer A.D., Fouteau S.,
RA Franken C., Gibelin C., Gish J., Goldstein S., Gonzalez A.J., Green P.J.,
RA Hallab A., Hartog M., Hua A., Humphray S.J., Jeong D.H., Jing Y.,
RA Jocker A., Kenton S.M., Kim D.J., Klee K., Lai H., Lang C., Lin S.,
RA Macmil S.L., Magdelenat G., Matthews L., McCorrison J., Monaghan E.L.,
RA Mun J.H., Najar F.Z., Nicholson C., Noirot C., O'Bleness M., Paule C.R.,
RA Poulain J., Prion F., Qin B., Qu C., Retzel E.F., Riddle C., Sallet E.,
RA Samain S., Samson N., Sanders I., Saurat O., Scarpelli C., Schiex T.,
RA Segurens B., Severin A.J., Sherrier D.J., Shi R., Sims S., Singer S.R.,
RA Sinharoy S., Sterck L., Viollet A., Wang B.B., Wang K., Wang M., Wang X.,
RA Warfsmann J., Weissenbach J., White D.D., White J.D., Wiley G.B.,
RA Wincker P., Xing Y., Yang L., Yao Z., Ying F., Zhai J., Zhou L., Zuber A.,
RA Denarie J., Dixon R.A., May G.D., Schwartz D.C., Rogers J., Quetier F.,
RA Town C.D., Roe B.A.;
RT "The Medicago genome provides insight into the evolution of rhizobial
RT symbioses.";
RL Nature 480:520-524(2011).
RN [4] {ECO:0000313|EMBL:AGI65360.1}
RP NUCLEOTIDE SEQUENCE.
RA Challis R., Hepworth J., Mouchel C., Waites R., Leyser O.;
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:AGI65360.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23424248; DOI=10.1104/pp.112.211383;
RA Challis R.J., Hepworth J., Mouchel C., Waites R., Leyser O.;
RT "A Role for MORE AXILLARY GROWTH1 (MAX1) in Evolutionary Diversity in
RT Strigolactone Signaling Upstream of MAX2.";
RL Plant Physiol. 161:1885-1902(2013).
RN [6] {ECO:0000313|EMBL:AES73413.1, ECO:0000313|Proteomes:UP000002051}
RP GENOME REANNOTATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:AES73413,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=24767513; DOI=10.1186/1471-2164-15-312;
RA Tang H., Krishnakumar V., Bidwell S., Rosen B., Chan A., Zhou S.,
RA Gentzbittel L., Childs K.L., Yandell M., Gundlach H., Mayer K.F.,
RA Schwartz D.C., Town C.D.;
RT "An improved genome release (version Mt4.0) for the model legume Medicago
RT truncatula.";
RL BMC Genomics 15:312-312(2014).
RN [7] {ECO:0000313|EnsemblPlants:AES73413}
RP IDENTIFICATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:AES73413};
RG EnsemblPlants;
RL Submitted (APR-2015) to UniProtKB.
RN [8] {ECO:0000313|EMBL:RHN70469.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaves {ECO:0000313|EMBL:RHN70469.1};
RA Pecrix Y., Gamas P., Carrere S.;
RT "Whole-genome landscape of Medicago truncatula symbiotic genes.";
RL Nat. Plants 0:0-0(2018).
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413;
CC Evidence={ECO:0000256|ARBA:ARBA00001971};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC {ECO:0000256|ARBA:ARBA00010617, ECO:0000256|RuleBase:RU000461}.
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DR EMBL; DQ335803; ABC59098.1; -; mRNA.
DR EMBL; CM001219; AES73413.1; -; Genomic_DNA.
DR EMBL; JX566696; AGI65360.1; -; mRNA.
DR EMBL; PSQE01000003; RHN70469.1; -; Genomic_DNA.
DR RefSeq; XP_003603162.1; XM_003603114.2.
DR AlphaFoldDB; Q2MIZ8; -.
DR SMR; Q2MIZ8; -.
DR STRING; 3880.Q2MIZ8; -.
DR PaxDb; 3880-AES73413; -.
DR EnsemblPlants; AES73413; AES73413; MTR_3g104560.
DR GeneID; 11430637; -.
DR Gramene; AES73413; AES73413; MTR_3g104560.
DR KEGG; mtr:11430637; -.
DR eggNOG; KOG0158; Eukaryota.
DR HOGENOM; CLU_001570_5_9_1; -.
DR OMA; SLEYMQM; -.
DR OrthoDB; 1611592at2759; -.
DR Proteomes; UP000002051; Chromosome 3.
DR Proteomes; UP000265566; Chromosome 3.
DR ExpressionAtlas; Q2MIZ8; differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070330; F:aromatase activity; IEA:UniProtKB-EC.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR036396; Cyt_P450_sf.
DR PANTHER; PTHR24301; THROMBOXANE-A SYNTHASE; 1.
DR PANTHER; PTHR24301:SF2; THROMBOXANE-A SYNTHASE; 1.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00463; EP450I.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
DR PROSITE; PS00086; CYTOCHROME_P450; 1.
PE 2: Evidence at transcript level;
KW Heme {ECO:0000256|ARBA:ARBA00022617, ECO:0000256|RuleBase:RU000461};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|RuleBase:RU000461};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU000461};
KW Monooxygenase {ECO:0000256|ARBA:ARBA00023033,
KW ECO:0000256|RuleBase:RU000461};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU000461};
KW Reference proteome {ECO:0000313|Proteomes:UP000002051};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 541 AA; 61336 MW; D15D6A514DC13784 CRC64;
MVFMDLEWLF PIPISVSFAS TILALAGGWL IYLYEPYWRV RKVPGPPSLP LVGHLHLLAK
HGPDVFSVLA KQYGPIYRFH MGRQPLIIVA DAELCKEVGI KKFKDIPNRS TPSPIKASPL
HQKGLFFSRD SQWSTMRNTI LSVYQPSHLS RLVPTMQSFI ESATQNLDSQ KEDIFFSNLS
LKLATDVIGQ AAFGVNFGLS QSHSVHNESK NVATDNKDLM NASGSNEVTD FINQHIYSTT
QLKMDLSGSF SIILGLLVPI LQEPFRQILK RIPGTMDWKI ERTNEKLGGR LDEIVEKRTK
DRTRSSKDFL SLILNARESK AVSENVFTPE YISAVTYEHL LAGSATTSFT LSSVVYLVAA
HPEVEKKMLE EIDGYGSLDQ IPTSQDLHDK FPYLDQVIKE AMRFYIVSPL VARETSNEVE
IGGYLLPKGT WVWLALGVLA KDHKNFPEPE KFKPERFDPN CEEMKQRHPY AFIPFGIGPR
ACIGQKFSMQ EIKLSLIHLY KKYLFRHSAD MESPLELEYG IVLNFKHGVK FSVIKRTEMS
C
//
