ID Q2NQC6_SODGM Unreviewed; 246 AA.
AC Q2NQC6;
DT 07-FEB-2006, integrated into UniProtKB/TrEMBL.
DT 07-FEB-2006, sequence version 1.
DT 27-MAR-2024, entry version 107.
DE RecName: Full=UDP-N-acetyl-D-mannosaminuronic acid transferase {ECO:0000256|HAMAP-Rule:MF_01001};
DE Short=UDP-ManNAcA transferase {ECO:0000256|HAMAP-Rule:MF_01001};
DE EC=2.4.1.180 {ECO:0000256|HAMAP-Rule:MF_01001};
GN Name=wecG {ECO:0000256|HAMAP-Rule:MF_01001,
GN ECO:0000313|EMBL:CRL46741.1};
GN Synonyms=rffM {ECO:0000256|HAMAP-Rule:MF_01001};
GN OrderedLocusNames=SG2374 {ECO:0000313|EMBL:BAE75649.1};
GN ORFNames=SGGMMB4_05611 {ECO:0000313|EMBL:CRL46741.1};
OS Sodalis glossinidius (strain morsitans).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Bruguierivoracaceae; Sodalis.
OX NCBI_TaxID=343509 {ECO:0000313|EMBL:BAE75649.1, ECO:0000313|Proteomes:UP000001932};
RN [1] {ECO:0000313|EMBL:BAE75649.1, ECO:0000313|Proteomes:UP000001932}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Morsitans {ECO:0000313|EMBL:BAE75649.1}, and morsitans
RC {ECO:0000313|Proteomes:UP000001932};
RX PubMed=16365377; DOI=10.1101/gr.4106106;
RA Toh H., Weiss B.L., Perkin S.A.H., Yamashita A., Oshima K., Hattori M.,
RA Aksoy S.;
RT "Massive genome erosion and functional adaptations provide insights into
RT the symbiotic lifestyle of Sodalis glossinidius in the tsetse host.";
RL Genome Res. 16:149-156(2006).
RN [2] {ECO:0000313|EMBL:CRL46741.1, ECO:0000313|Proteomes:UP000245838}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B4 {ECO:0000313|EMBL:CRL46741.1}, and morsitans
RC {ECO:0000313|Proteomes:UP000245838};
RA Goodhead I.;
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA (Lipid II),
CC the second lipid-linked intermediate involved in enterobacterial common
CC antigen (ECA) synthesis. {ECO:0000256|HAMAP-Rule:MF_01001}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl
CC diphosphate + UDP-N-acetyl-alpha-D-mannosaminouronate = beta-D-
CC ManNAcA-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl
CC diphosphate + H(+) + UDP; Xref=Rhea:RHEA:28366, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:58223, ChEBI:CHEBI:61495, ChEBI:CHEBI:62959,
CC ChEBI:CHEBI:70731; EC=2.4.1.180; Evidence={ECO:0000256|HAMAP-
CC Rule:MF_01001};
CC -!- PATHWAY: Bacterial outer membrane biogenesis; enterobacterial common
CC antigen biosynthesis. {ECO:0000256|HAMAP-Rule:MF_01001}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 26 family.
CC {ECO:0000256|HAMAP-Rule:MF_01001}.
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DR EMBL; AP008232; BAE75649.1; -; Genomic_DNA.
DR EMBL; LN854557; CRL46741.1; -; Genomic_DNA.
DR RefSeq; WP_011412180.1; NZ_LN854557.1.
DR STRING; 343509.SG2374; -.
DR CAZy; GT26; Glycosyltransferase Family 26.
DR KEGG; sgl:SG2374; -.
DR eggNOG; COG1922; Bacteria.
DR HOGENOM; CLU_063203_3_2_6; -.
DR OrthoDB; 9808602at2; -.
DR BioCyc; SGLO343509:SGP1_RS21625-MONOMER; -.
DR UniPathway; UPA00566; -.
DR Proteomes; UP000001932; Chromosome.
DR Proteomes; UP000245838; Chromosome sggmmb4_Chromosome.
DR GO; GO:0047241; F:lipopolysaccharide N-acetylmannosaminouronosyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0009246; P:enterobacterial common antigen biosynthetic process; IEA:UniProtKB-UniRule.
DR CDD; cd06533; Glyco_transf_WecG_TagA; 1.
DR HAMAP; MF_01001; WecG_RffM; 1.
DR InterPro; IPR023085; UDP-ManNAcA_Trfase_WecG.
DR InterPro; IPR004629; WecG_TagA_CpsF.
DR NCBIfam; TIGR00696; wecG_tagA_cpsF; 1.
DR PANTHER; PTHR34136; -; 1.
DR PANTHER; PTHR34136:SF1; UDP-N-ACETYL-D-MANNOSAMINURONIC ACID TRANSFERASE; 1.
DR Pfam; PF03808; Glyco_tran_WecG; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase {ECO:0000256|HAMAP-Rule:MF_01001};
KW Transferase {ECO:0000256|HAMAP-Rule:MF_01001, ECO:0000313|EMBL:BAE75649.1}.
SQ SEQUENCE 246 AA; 27851 MW; FFB7F04086A153D5 CRC64;
MHNNDGVPHY QIRGLSLWGF RDRADFIDYL FAGGRLKTGT LVAINAEKVL NAERDAALKK
LLDEAEYKYA DGISIVRSIR RKYRHAEVSR IAGADLWEDL MARAGREGVP VFLVGGRPVV
LMRTEAQLRA RWNVNIVGRQ DGYFSVDAQP ALVERIRASG AAIVTVAMGS PRQEQLIALI
RREHPAALYM GVGGTYDVFT RHVKRAPKGW QDLGLEWLYR LLSQPSRLQR QLKLLRYLGY
HISGRL
//
