ID Q2PEQ9_TRIPR Unreviewed; 537 AA.
AC Q2PEQ9;
DT 07-FEB-2006, integrated into UniProtKB/TrEMBL.
DT 07-FEB-2006, sequence version 1.
DT 24-JAN-2024, entry version 48.
DE RecName: Full=PA domain-containing protein {ECO:0000259|Pfam:PF02225};
OS Trifolium pratense (Red clover).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Trifolieae; Trifolium.
OX NCBI_TaxID=57577 {ECO:0000313|EMBL:BAE71293.1};
RN [1] {ECO:0000313|EMBL:BAE71293.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=13679984; DOI=10.1007/s00122-003-1412-z;
RA Isobe S., Klimenko I., Ivashuta S., Gau M., Kozlov N.N.;
RT "First RFLP linkage map of red clover ( Trifolium pratense L.) based on
RT cDNA probes and its transferability to other red clover germplasm.";
RL Theor. Appl. Genet. 108:105-112(2003).
RN [2] {ECO:0000313|EMBL:BAE71293.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=16769692; DOI=10.1093/dnares/dsi018;
RA Sato S., Isobe S., Asamizu E., Ohmido N., Kataoka R., Nakamura Y.,
RA Kaneko T., Sakurai N., Okumura K., Klimenko I., Sasamoto S., Wada T.,
RA Watanabe A., Kohara M., Fujishiro T., Tabata S.;
RT "Comprehensive structural analysis of the genome of red clover (Trifolium
RT pratense L.).";
RL DNA Res. 12:301-364(2005).
CC -!- FUNCTION: Intramembrane-cleaving aspartic protease (I-CLiP) that
CC cleaves type II membrane signal peptides in the hydrophobic plane of
CC the membrane. {ECO:0000256|ARBA:ARBA00003012}.
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004337}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the peptidase A22B family.
CC {ECO:0000256|ARBA:ARBA00006859}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB236841; BAE71293.1; -; mRNA.
DR AlphaFoldDB; Q2PEQ9; -.
DR EnsemblPlants; Tp57577_TGAC_v2_mRNA16141; Tp57577_TGAC_v2_mRNA16141; Tp57577_TGAC_v2_gene15618.
DR Gramene; Tp57577_TGAC_v2_mRNA16141; Tp57577_TGAC_v2_mRNA16141; Tp57577_TGAC_v2_gene15618.
DR ExpressionAtlas; Q2PEQ9; baseline.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042500; F:aspartic endopeptidase activity, intramembrane cleaving; IEA:InterPro.
DR CDD; cd02132; PA_GO-like; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR InterPro; IPR046450; PA_dom_sf.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR007369; Peptidase_A22B_SPP.
DR InterPro; IPR006639; Preselin/SPP.
DR PANTHER; PTHR12174; SIGNAL PEPTIDE PEPTIDASE; 1.
DR PANTHER; PTHR12174:SF90; SIGNAL PEPTIDE PEPTIDASE-LIKE 3; 1.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF04258; Peptidase_A22B; 1.
DR SMART; SM00730; PSN; 1.
DR SUPFAM; SSF52025; PA domain; 1.
PE 2: Evidence at transcript level;
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..537
FT /note="PA domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004213520"
FT TRANSMEM 254..272
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 278..302
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 323..341
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 347..367
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 374..397
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 429..450
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 462..482
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 494..512
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 92..169
FT /note="PA"
FT /evidence="ECO:0000259|Pfam:PF02225"
SQ SEQUENCE 537 AA; 58795 MW; 7FE20CF41B83C89B CRC64;
MPSPSRGRRF FLSVLLVLLF FVTASASDDV KRDDDRAPKS KSCNNPFQLV KVKNWVDGDE
AITHSGMTAR FGSSLPEKAD NSVRTRVLFS NPTDCCSPST SQLSDSVALC VRGGCDFQIK
ATIAQSGGAT AVLIINDQED LVEMVCSDTT EANISIPVVM ITKSAGEALN ASLTTGKRVE
VLLYAPPRPL VDFSVAFLWL VSVGTIVCAS LWSDITTPEK SGERYNELYP KESQNAAAAR
GGSDKQVVNI NSKAAVIFII SASTFLVLLF FFMSSWFLWL LIVLFCIAGI EGMHNCITTL
TLRKWENCGE KTVNVPLFGE TSIFSLVVCL FCFAFAVFWA STRHASYSWI FQDTLGICLI
ITVLQVAQLP NIKVATVLLS CAFAYDIFWV FISPLIFHES VMIAVARGDK AGGEALPMLL
RFPRFFDTWG GYEMIGFGDI IFPGLLVSFA HRLDKDNKKG ALNGYFLWLV IGYGVGLIFT
YLGLYLMDGN GQPALLYLVP CTLGVIIILG FARGELKSLW NYGTDSSLST EPADSEV
//
