ID Q2UGW4_ASPOR Unreviewed; 641 AA.
AC Q2UGW4;
DT 24-JAN-2006, integrated into UniProtKB/TrEMBL.
DT 24-JAN-2006, sequence version 1.
DT 24-JAN-2024, entry version 71.
DE RecName: Full=Lysophospholipase {ECO:0000256|ARBA:ARBA00013274, ECO:0000256|RuleBase:RU362103};
DE EC=3.1.1.5 {ECO:0000256|ARBA:ARBA00013274, ECO:0000256|RuleBase:RU362103};
GN ORFNames=AO090023000685 {ECO:0000313|EMBL:BAE59201.1};
OS Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=510516 {ECO:0000313|EMBL:BAE59201.1, ECO:0000313|Proteomes:UP000006564};
RN [1] {ECO:0000313|EMBL:BAE59201.1, ECO:0000313|Proteomes:UP000006564}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 42149 / RIB 40 {ECO:0000313|Proteomes:UP000006564};
RX PubMed=16372010; DOI=10.1038/nature04300;
RA Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA Takahashi M., Takase K., Terabayashi Y., Wortman J., Yamada O.,
RA Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA Kikuchi H.;
RT "Genome sequencing and analysis of Aspergillus oryzae.";
RL Nature 438:1157-1161(2005).
CC -!- FUNCTION: Catalyzes the release of fatty acids from lysophospholipids.
CC {ECO:0000256|ARBA:ARBA00002169}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid +
CC H(+) + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:15177,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870,
CC ChEBI:CHEBI:28868, ChEBI:CHEBI:58168; EC=3.1.1.5;
CC Evidence={ECO:0000256|ARBA:ARBA00000960,
CC ECO:0000256|RuleBase:RU362103};
CC -!- SIMILARITY: Belongs to the lysophospholipase family.
CC {ECO:0000256|ARBA:ARBA00008780, ECO:0000256|RuleBase:RU362103}.
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DR EMBL; AP007157; BAE59201.1; -; Genomic_DNA.
DR RefSeq; XP_001821203.1; XM_001821151.2.
DR AlphaFoldDB; Q2UGW4; -.
DR STRING; 510516.Q2UGW4; -.
DR EnsemblFungi; BAE59201; BAE59201; AO090023000685.
DR GeneID; 5993205; -.
DR KEGG; aor:AO090023000685; -.
DR VEuPathDB; FungiDB:AO090023000685; -.
DR HOGENOM; CLU_014602_0_0_1; -.
DR OMA; FARYCWN; -.
DR OrthoDB; 1826981at2759; -.
DR Proteomes; UP000006564; Chromosome 3.
DR GO; GO:0004622; F:lysophospholipase activity; IEA:UniProtKB-EC.
DR GO; GO:0102545; F:phosphatidyl phospholipase B activity; IEA:UniProtKB-EC.
DR GO; GO:0009395; P:phospholipid catabolic process; IEA:InterPro.
DR CDD; cd07203; cPLA2_Fungal_PLB; 1.
DR Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 1.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR002642; LysoPLipase_cat_dom.
DR PANTHER; PTHR10728; CYTOSOLIC PHOSPHOLIPASE A2; 1.
DR PANTHER; PTHR10728:SF62; LYSOPHOSPHOLIPASE; 1.
DR Pfam; PF01735; PLA2_B; 1.
DR SMART; SM00022; PLAc; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR PROSITE; PS51210; PLA2C; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00555,
KW ECO:0000256|RuleBase:RU362103};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963, ECO:0000256|PROSITE-
KW ProRule:PRU00555};
KW Lipid metabolism {ECO:0000256|PROSITE-ProRule:PRU00555,
KW ECO:0000256|RuleBase:RU362103};
KW Reference proteome {ECO:0000313|Proteomes:UP000006564};
KW Signal {ECO:0000256|RuleBase:RU362103}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|RuleBase:RU362103"
FT CHAIN 20..641
FT /note="Lysophospholipase"
FT /evidence="ECO:0000256|RuleBase:RU362103"
FT /id="PRO_5005143037"
FT DOMAIN 53..601
FT /note="PLA2c"
FT /evidence="ECO:0000259|PROSITE:PS51210"
SQ SEQUENCE 641 AA; 69423 MW; 0348BC0D88122DEC CRC64;
MKPTTAAIAL AGLLSGVTAA PGPHGERIER IDRTVLERAL PNAPDGYVPS NVSCPANRPT
VRSASSGLSS NETSWLKTRR EKTQSAMKDF FNHVTIKDFD AVQYLDNHSS NTSNLPNIGI
AVSGGGYRAL MNGAGAIKAF DSRTENSTAT GQLGGLLQSA TYLAGLSGGG WLVGSIYINN
FTTISALQTH EDGAVWQFQN SIFEGPDGDS IQILDSATYY KHVYDAVQDK KDAGYETSIT
DYWGRALSYQ LINATDGGPS YTWSSIALTD TFKQADMPMP LLVADGRYPD ELVVSSNATV
YEFNPWEFGT FDPTVYGFVP LEYVGSKFDG GSIPDNETCV RGFDNAGFVM GTSSSLFNQF
FLQVNSTSLP DFLKTAFSDI LAKIGEEDED IAVYAPNPFY NWAPESSPAA HQQELDMVDG
GEDLQNIPLH PLIQPERHVD VIFAVDSSAD TTYSWPNGTA LVATYERSLN STGIANGTSF
PAIPDQNTFV NNGLNTRPTF FGCNSTNTTG PTPLVVYLPN YPYVSYSNWS TFQPSYEISE
RDDTIRNGYD VVTMGNSTRD GNWTTCVGCA ILSRSFERTN TQVPDACTQC FQKYCWDGTT
NSTNPADYEP VTLLEDSAGS ALSPAVITTI VATSAALFTL L
//
