ID Q2UIJ6_ASPOR Unreviewed; 731 AA.
AC Q2UIJ6;
DT 24-JAN-2006, integrated into UniProtKB/TrEMBL.
DT 24-JAN-2006, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=DUF2421 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=AO090023000031 {ECO:0000313|EMBL:BAE58619.1};
OS Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=510516 {ECO:0000313|EMBL:BAE58619.1, ECO:0000313|Proteomes:UP000006564};
RN [1] {ECO:0000313|EMBL:BAE58619.1, ECO:0000313|Proteomes:UP000006564}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 42149 / RIB 40 {ECO:0000313|Proteomes:UP000006564};
RX PubMed=16372010; DOI=10.1038/nature04300;
RA Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA Takahashi M., Takase K., Terabayashi Y., Wortman J., Yamada O.,
RA Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA Kikuchi H.;
RT "Genome sequencing and analysis of Aspergillus oryzae.";
RL Nature 438:1157-1161(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AP007157; BAE58619.1; -; Genomic_DNA.
DR AlphaFoldDB; Q2UIJ6; -.
DR STRING; 510516.Q2UIJ6; -.
DR EnsemblFungi; BAE58619; BAE58619; AO090023000031.
DR VEuPathDB; FungiDB:AO090023000031; -.
DR HOGENOM; CLU_003918_0_0_1; -.
DR OMA; DTHIPSY; -.
DR OrthoDB; 2600958at2759; -.
DR Proteomes; UP000006564; Chromosome 3.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR InterPro; IPR018823; ArAE_2_N.
DR InterPro; IPR018820; BRE4-related_DUF2421.
DR InterPro; IPR049453; Memb_transporter_dom.
DR PANTHER; PTHR37994:SF3; ARAE_2_N DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR37994; ARAE_2_N DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR Pfam; PF10334; ArAE_2; 1.
DR Pfam; PF10337; ArAE_2_N; 1.
DR Pfam; PF13515; FUSC_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006564};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 355..372
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 384..400
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 407..427
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 433..452
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 459..477
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 497..517
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..216
FT /note="Putative ER transporter 6TM N-terminal"
FT /evidence="ECO:0000259|Pfam:PF10337"
FT DOMAIN 378..513
FT /note="Integral membrane bound transporter"
FT /evidence="ECO:0000259|Pfam:PF13515"
FT DOMAIN 518..722
FT /note="DUF2421"
FT /evidence="ECO:0000259|Pfam:PF10334"
SQ SEQUENCE 731 AA; 81733 MW; 751A3878F1024377 CRC64;
MEDIVELLKQ PLAFTSVTLG KKAQQPDVDR LHKTHAQIIQ EYRKMEPGLA FLPLDFSVGR
WGPEEVASFK EPMRQVVAAI LLLLEFHIGR IHGEVRTEDI LREHAEQTKN GDITDEKQPR
KVGAQQLSQL VELLEGLRSS GNQQLPQEIV DELVHTSAMA IDACLEGLTA TRECIHMVNC
RRWVRRAPPT EREDLYQRSR TALENLRKAH SGFLRDMTEL LIGHFAPTTN GESRDQRKIG
ALVVGMVFEE HVCITITRTQ ALLDRVSTAF HDSKGTKLWW PTSLRYAASW AFRKKAKAPT
TTTVVEDDPD EAEDLTKAAQ EKLRISRGYR PKNRSPLGRA ILGTYHWFTS NEGLFALRMV
VVTIALGIPG VIPHTAGFYY REKGLWGLIM AQTGLLVYMS EFTFSTLGRL VGTVAGGVLG
LLAWYIGSAN GPGNPYGLSA VMAVMLAILM WIRLYLPPNL VQGGIMGGAT FMLVVAYSYD
DTHIPSYGNP GVGYTVFWRR LLLVLIGVGA ATIVQLFPRP PSAARHICKT LSHTVRTLSD
HYALLLSCWG RSRHDGRVLA EPISLQLTEG LVMLDGPIDM LRFDFSSSRF DSESLGRVKR
LCHIMNRTLG QLLLLSGTLP NEFQHRLAQQ TALLDHQCIG EIMAVLGMCE QALKTGDALP
EILPTPLVRR AFDYWQSHPA EIDFSPETVR DENYRRFCVA LSAYLKFLGT IDELVLVIKG
VLDYTGSRVR V
//
